SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hbc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 291
VAL A 284
TRP A 304
 None
None
EDO  A   7 (-3.9A)
 0.83A 1av2A-3hbcA:
undetectable
1av2B-3hbcA:
undetectable		 1av2A-3hbcA:
4.37
1av2B-3hbcA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 131
ARG A  59
GLY A  60
TYR A 129
 None
GOL  A   2 (-3.8A)
None
None
 1.01A 1fapB-3hbcA:
undetectable		 1fapB-3hbcA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 105
SER A 200
SER A 277
ALA A  25
 None
 1.12A 1fxvA-3hbcA:
undetectable
1fxvB-3hbcA:
12.8		 1fxvA-3hbcA:
22.60
1fxvB-3hbcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 305
TYR A 329
GLY A 331
LEU A 337
 None
 0.72A 1jlbA-3hbcA:
undetectable		 1jlbA-3hbcA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 HIS A  66
ALA A 120
PHE A 149
GLY A  65
 GOL  A   5 (-4.7A)
None
None
None
 1.32A 1mj2B-3hbcA:
undetectable		 1mj2B-3hbcA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 HIS A  66
ALA A 120
PHE A 149
GLY A  65
 GOL  A   5 (-4.7A)
None
None
None
 1.33A 1mj2D-3hbcA:
undetectable		 1mj2D-3hbcA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 HIS A  66
ALA A 120
PHE A 149
GLY A  65
 GOL  A   5 (-4.7A)
None
None
None
 1.32A 1mjoB-3hbcA:
undetectable		 1mjoB-3hbcA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 HIS A  66
ALA A 120
PHE A 149
GLY A  65
 GOL  A   5 (-4.7A)
None
None
None
 1.33A 1mjoA-3hbcA:
undetectable		 1mjoA-3hbcA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 HIS A  66
ALA A 120
PHE A 149
GLY A  65
 GOL  A   5 (-4.7A)
None
None
None
 1.32A 1mjoD-3hbcA:
undetectable		 1mjoD-3hbcA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A  30
THR A  40
GLN A 287
ILE A 169
 None
 1.23A 1ss4A-3hbcA:
undetectable		 1ss4A-3hbcA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 291
VAL A 284
TRP A 304
 None
None
EDO  A   7 (-3.9A)
 0.73A 1w5uA-3hbcA:
undetectable
1w5uB-3hbcA:
undetectable		 1w5uA-3hbcA:
4.37
1w5uB-3hbcA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 284
TRP A 304
VAL A 291
 None
EDO  A   7 (-3.9A)
None
 0.82A 2izqC-3hbcA:
undetectable
2izqD-3hbcA:
undetectable		 2izqC-3hbcA:
4.37
2izqD-3hbcA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 141
ASP A 142
GLU A 190
 None
 0.54A 2qeuA-3hbcA:
undetectable		 2qeuA-3hbcA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 141
ASP A 142
GLU A 190
 None
 0.54A 2qeuC-3hbcA:
undetectable		 2qeuC-3hbcA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 105
LYS A 163
SER A 109
 None
 1.36A 3tyeB-3hbcA:
undetectable		 3tyeB-3hbcA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 284
GLY A  41
TYR A 292
ASP A  92
 None
 1.42A 3w9tA-3hbcA:
undetectable		 3w9tA-3hbcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 284
GLY A  41
TYR A 292
ASP A  92
 None
 1.43A 3w9tB-3hbcA:
undetectable		 3w9tB-3hbcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 284
GLY A  41
TYR A 292
ASP A  92
 None
 1.42A 3w9tC-3hbcA:
undetectable		 3w9tC-3hbcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 284
GLY A  41
TYR A 292
ASP A  92
 None
 1.42A 3w9tD-3hbcA:
undetectable		 3w9tD-3hbcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 284
GLY A  41
TYR A 292
ASP A  92
 None
 1.42A 3w9tE-3hbcA:
undetectable		 3w9tE-3hbcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 284
GLY A  41
TYR A 292
ASP A  92
 None
 1.42A 3w9tF-3hbcA:
undetectable		 3w9tF-3hbcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 284
GLY A  41
TYR A 292
ASP A  92
 None
 1.43A 3w9tG-3hbcA:
undetectable		 3w9tG-3hbcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A  38
VAL A  30
ASN A  95
VAL A 178
 None
 1.08A 4e1gB-3hbcA:
undetectable		 4e1gB-3hbcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A  32
VAL A  30
ASP A 171
VAL A 100
 None
 1.04A 4l4bA-3hbcA:
undetectable		 4l4bA-3hbcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 9 SER A 285
SER A 283
ASP A  92
GLY A  41
THR A  40
 None
 1.29A 4lb0A-3hbcA:
undetectable		 4lb0A-3hbcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A  27
GLY A  41
ALA A  29
ILE A 239
 None
 0.84A 4txnA-3hbcA:
undetectable		 4txnA-3hbcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A  27
GLY A  41
ALA A  29
ILE A 239
 None
 0.84A 4txnB-3hbcA:
undetectable		 4txnB-3hbcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A  27
GLY A  41
ALA A  29
ILE A 239
 None
 0.89A 4txnC-3hbcA:
undetectable		 4txnC-3hbcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A  27
GLY A  41
ALA A  29
ILE A 239
 None
 0.83A 4txnD-3hbcA:
undetectable		 4txnD-3hbcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A  38
LEU A 104
MET A 197
 None
 0.89A 5ikrA-3hbcA:
undetectable		 5ikrA-3hbcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  99
ILE A 125
MET A 121
TRP A  74
 None
GOL  A   5 (-4.5A)
None
None
 1.39A 5ljcA-3hbcA:
undetectable		 5ljcA-3hbcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 203
ALA A 168
GLN A 195
THR A 170
 None
 1.11A 5n0wB-3hbcA:
undetectable		 5n0wB-3hbcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 203
ALA A 168
GLN A 195
THR A 170
 None
 1.13A 5n4iA-3hbcA:
undetectable		 5n4iA-3hbcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 293
ASP A 306
ASP A 286
 None
EDO  A   7 (-4.2A)
None
 0.63A 5x6yA-3hbcA:
undetectable		 5x6yA-3hbcA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A  32
VAL A  30
ASP A 171
VAL A 100
 None
 1.01A 6cp4A-3hbcA:
undetectable		 6cp4A-3hbcA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A  38
LEU A  32
HIS A 240
THR A 176
 None
 1.19A 6dyoA-3hbcA:
undetectable		 6dyoA-3hbcA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3hbc CHOLOYLGLYCINE
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A 295
ARG A 260
VAL A 252
PRO A 253
 None
 1.31A 6fgdA-3hbcA:
undetectable		 6fgdA-3hbcA:
21.97