SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hbj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 12 ALA A 147
ASP A 376
ILE A 362
LEU A 388
ILE A 227
 None
 1.31A 1d1gA-3hbjA:
undetectable		 1d1gA-3hbjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 8 PHE A  95
ARG A  89
MET A 205
PHE A  23
 None
 1.14A 1gsfA-3hbjA:
undetectable		 1gsfA-3hbjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 8 PHE A  95
ARG A  89
MET A 205
PHE A  23
 None
 1.14A 1gsfB-3hbjA:
undetectable		 1gsfB-3hbjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 8 PHE A  95
ARG A  89
MET A 205
PHE A  23
 None
 1.14A 1gsfD-3hbjA:
undetectable		 1gsfD-3hbjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		3 / 3 SER A 353
GLU A 385
ASP A 395
 None
 0.69A 2avdB-3hbjA:
5.2		 2avdB-3hbjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 8 LEU A 179
ILE A 231
LEU A 383
ILE A 382
 None
 0.68A 2azxA-3hbjA:
3.1		 2azxA-3hbjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 12 THR A 384
GLY A 393
GLY A 391
MET A 368
VAL A 398
 None
 1.13A 2b25B-3hbjA:
3.9		 2b25B-3hbjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 11 MET A 137
LEU A 133
PHE A 129
LEU A 121
VAL A  74
 None
 1.21A 2po5B-3hbjA:
3.2		 2po5B-3hbjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 12 MET A 137
LEU A 133
PHE A 129
LEU A 121
VAL A  74
 None
 1.14A 2po7A-3hbjA:
3.2		 2po7A-3hbjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 7 ILE A 227
THR A 154
ILE A 362
GLY A 378
 None
 0.76A 2v0mB-3hbjA:
undetectable		 2v0mB-3hbjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 7 GLY A 246
SER A 441
ALA A 431
ALA A 434
VAL A 363
 None
 1.14A 3a2qA-3hbjA:
undetectable		 3a2qA-3hbjA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 12 ILE A 231
LEU A 383
ILE A 382
ILE A 161
PHE A 182
 None
 1.02A 3b2rA-3hbjA:
undetectable		 3b2rA-3hbjA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		3 / 3 ARG A  61
LEU A  31
THR A 252
 None
 0.67A 3oxcA-3hbjA:
undetectable		 3oxcA-3hbjA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 12 MET A 137
LEU A 133
PHE A 129
LEU A 121
VAL A  74
 None
 1.20A 3w1wA-3hbjA:
3.0		 3w1wA-3hbjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 9 VAL A 219
PRO A 143
LEU A 213
TRP A 145
LEU A 152
 None
 1.25A 3w1wA-3hbjA:
3.1
3w1wB-3hbjA:
3.4		 3w1wA-3hbjA:
22.36
3w1wB-3hbjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 12 MET A 137
LEU A 133
PHE A 129
LEU A 121
VAL A  74
 None
 1.18A 3w1wB-3hbjA:
3.4		 3w1wB-3hbjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		3 / 3 ASP A 132
LEU A 121
VAL A 219
 None
 0.69A 4jecB-3hbjA:
undetectable		 4jecB-3hbjA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 9 ALA A 431
VAL A 363
GLY A 246
VAL A 358
ILE A 362
 None
 1.20A 4ll3B-3hbjA:
undetectable		 4ll3B-3hbjA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 12 HIS A 228
LEU A 153
VAL A 178
ASP A 189
THR A 154
 None
 1.28A 4mubA-3hbjA:
1.9		 4mubA-3hbjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 12 SER A 441
PHE A 445
LEU A 144
PHE A 248
GLY A 246
 None
 1.00A 4pevC-3hbjA:
undetectable		 4pevC-3hbjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 7 MET A 368
HIS A 150
GLY A 378
ASN A 380
 None
 1.00A 5a5zC-3hbjA:
undetectable		 5a5zC-3hbjA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 5 PHE A 239
HIS A 155
LEU A 153
PRO A 214
 None
 1.45A 5csyB-3hbjA:
undetectable		 5csyB-3hbjA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 11 ALA A 407
VAL A 348
LEU A 350
LEU A 294
VAL A 276
 None
 1.22A 5eb5A-3hbjA:
undetectable		 5eb5A-3hbjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 6 ILE A  92
PHE A  95
THR A 146
TRP A 145
 None
 1.04A 5g08A-3hbjA:
undetectable		 5g08A-3hbjA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 10 ILE A 231
PRO A 180
LEU A 153
VAL A 194
LEU A 190
 None
 1.00A 5ienB-3hbjA:
undetectable		 5ienB-3hbjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		4 / 6 GLY A 354
THR A 384
VAL A 358
TRP A 355
 UDP  A 900 (-3.5A)
None
None
None
 1.07A 5ysiA-3hbjA:
undetectable		 5ysiA-3hbjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 10 LEU A  19
ALA A  20
LEU A  30
ILE A  69
LEU A  58
 None
 1.33A 6cbzB-3hbjA:
undetectable		 6cbzB-3hbjA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		3 / 3 LEU A 379
GLY A 148
PHE A 126
 None
 0.55A 6exiC-3hbjA:
5.4		 6exiC-3hbjA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 11 GLY A 375
LEU A 206
SER A 151
PHE A 126
HIS A  26
 None
 1.23A 6qgbA-3hbjA:
2.7		 6qgbA-3hbjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 10 GLY A 375
LEU A 206
SER A 151
PHE A 126
HIS A  26
 None
 1.22A 6qgbB-3hbjA:
3.4		 6qgbB-3hbjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_C_BEZC701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 9 GLY A 375
LEU A 206
SER A 151
PHE A 126
HIS A  26
 None
 1.21A 6qgbC-3hbjA:
0.0		 6qgbC-3hbjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 10 GLY A 375
LEU A 206
SER A 151
PHE A 126
HIS A  26
 None
 1.21A 6qgbD-3hbjA:
0.7		 6qgbD-3hbjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 11 GLY A 375
LEU A 206
SER A 151
PHE A 126
HIS A  26
 None
 1.22A 6qgbE-3hbjA:
3.6		 6qgbE-3hbjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE
(Medicago
truncatula) 		5 / 10 GLY A 375
LEU A 206
SER A 151
PHE A 126
HIS A  26
 None
 1.24A 6qgbF-3hbjA:
3.2		 6qgbF-3hbjA:
20.53