SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hbu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		5 / 12 ARG P 183
PHE P 133
ILE P 131
TYR P 166
HIS P 192
 None
None
None
None
ZN  P 487 ( 2.9A)
 1.45A 1ot7A-3hbuP:
0.0		 1ot7A-3hbuP:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		5 / 12 GLU P 341
ASN P 359
GLY P 375
SER P 323
ILE P 340
 CA  P 481 (-2.2A)
CA  P 483 (-3.2A)
CA  P 489 (-4.3A)
None
None
 1.10A 1q8jB-3hbuP:
undetectable		 1q8jB-3hbuP:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 GLY P 320
ILE P 248
VAL P 338
SER P 294
 None
 1.24A 1rs7A-3hbuP:
undetectable		 1rs7A-3hbuP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 6 GLY P 363
ILE P 344
GLN P 362
SER P 307
 CA  P 482 (-4.4A)
None
None
None
 0.93A 1rs7B-3hbuP:
undetectable		 1rs7B-3hbuP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 6 GLY P 364
ILE P 344
GLN P 362
SER P 307
 CA  P 482 (-4.2A)
None
None
None
 1.05A 1rs7B-3hbuP:
undetectable		 1rs7B-3hbuP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 7 ASP P 463
ASN P 421
PHE P 419
GLN P 437
 None
 1.01A 2jc9A-3hbuP:
undetectable		 2jc9A-3hbuP:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 7 THR P 119
PHE P 120
THR P 121
LYS P 106
 None
 0.99A 2kotA-3hbuP:
undetectable		 2kotA-3hbuP:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 LEU P 361
ASP P 377
ILE P 315
GLY P 372
 None
CA  P 483 ( 2.4A)
None
CA  P 483 (-4.3A)
 0.95A 3bufA-3hbuP:
undetectable		 3bufA-3hbuP:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		3 / 3 ASN P 349
ASP P 412
GLN P 408
 None
CA  P 485 (-2.7A)
CA  P 485 (-3.5A)
 0.78A 3eeyC-3hbuP:
undetectable		 3eeyC-3hbuP:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		3 / 3 ASN P 349
ASP P 412
GLN P 408
 None
CA  P 485 (-2.7A)
CA  P 485 (-3.5A)
 0.80A 3eeyD-3hbuP:
undetectable		 3eeyD-3hbuP:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		3 / 3 ASN P 349
ASP P 412
GLN P 408
 None
CA  P 485 (-2.7A)
CA  P 485 (-3.5A)
 0.78A 3eeyE-3hbuP:
undetectable		 3eeyE-3hbuP:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		3 / 3 TYR P  24
GLY P 391
ASP P 395
 None
 0.67A 3ou6C-3hbuP:
undetectable		 3ou6C-3hbuP:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 GLU P 179
GLY P 182
TYR P 242
GLN P 184
 None
 1.44A 3w9tB-3hbuP:
undetectable		 3w9tB-3hbuP:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 GLU P 179
GLY P 182
TYR P 242
GLN P 184
 None
 1.44A 3w9tD-3hbuP:
undetectable		 3w9tD-3hbuP:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 GLU P 179
GLY P 182
TYR P 242
GLN P 184
 None
 1.47A 3w9tE-3hbuP:
undetectable		 3w9tE-3hbuP:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 GLU P 179
GLY P 182
TYR P 242
GLN P 184
 None
 1.49A 3w9tG-3hbuP:
undetectable		 3w9tG-3hbuP:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 GLY P 320
ILE P 248
VAL P 338
SER P 294
 None
 1.23A 4d33A-3hbuP:
undetectable		 4d33A-3hbuP:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 GLY P 320
ILE P 248
VAL P 338
SER P 294
 None
 1.20A 4d33B-3hbuP:
undetectable		 4d33B-3hbuP:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 8 SER P  22
LEU P 416
ALA P 418
SER P  21
 None
 0.82A 4iklA-3hbuP:
undetectable
4iklB-3hbuP:
undetectable		 4iklA-3hbuP:
15.27
4iklB-3hbuP:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		5 / 10 GLY P 330
ASN P 331
VAL P 325
GLN P 313
PHE P  30
 None
 1.50A 4j4vB-3hbuP:
undetectable		 4j4vB-3hbuP:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		5 / 10 GLY P 330
ASN P 331
VAL P 325
GLN P 313
PHE P  30
 None
 1.49A 4j4vA-3hbuP:
0.0
4j4vE-3hbuP:
0.0		 4j4vA-3hbuP:
19.49
4j4vE-3hbuP:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 7 TYR P 238
GLN P  56
THR P  58
THR P 187
 None
 1.10A 4mbsA-3hbuP:
undetectable		 4mbsA-3hbuP:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		3 / 3 ALA P 152
GLN P 184
GLY P 243
 None
 0.58A 4odoC-3hbuP:
undetectable		 4odoC-3hbuP:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 5 ILE P 292
PHE P 186
SER P 294
ASP P 280
 None
 1.35A 4rzvB-3hbuP:
undetectable		 4rzvB-3hbuP:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 6 ALA P 472
LYS P 409
GLN P 471
LEU P 441
 None
 1.07A 4xoyA-3hbuP:
undetectable		 4xoyA-3hbuP:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 8 SER P 275
GLY P 272
ILE P 334
SER P 333
 None
 0.85A 5alcL-3hbuP:
undetectable		 5alcL-3hbuP:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		5 / 12 LEU P 107
ILE P 131
LEU P  76
GLY P 191
GLY P 244
 None
 1.11A 5d4uA-3hbuP:
undetectable		 5d4uA-3hbuP:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 6 SER P 321
GLY P 354
ASN P 355
ILE P 315
 None
CA  P 483 ( 4.7A)
None
None
 0.84A 5j4nA-3hbuP:
undetectable		 5j4nA-3hbuP:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 8 TRP P 112
ALA P 245
GLN P 184
HIS P 226
 None
None
None
ZN  P 487 (-3.8A)
 1.06A 5km8A-3hbuP:
undetectable
5km8B-3hbuP:
undetectable		 5km8A-3hbuP:
12.63
5km8B-3hbuP:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 4 VAL P 369
LEU P 370
LEU P 361
ASP P 377
 None
None
None
CA  P 483 ( 2.4A)
 1.05A 5xv7A-3hbuP:
undetectable		 5xv7A-3hbuP:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		5 / 7 GLY P 346
GLY P 345
GLY P 363
GLY P 381
GLY P 382
 CA  P 482 (-4.4A)
CA  P 482 ( 4.7A)
CA  P 482 (-4.4A)
CA  P 485 (-4.5A)
CA  P 484 (-4.0A)
 0.99A 6ag0A-3hbuP:
undetectable		 6ag0A-3hbuP:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		3 / 3 GLN P 313
TYR P 309
ASN P 311
 None
 1.07A 6dwdC-3hbuP:
undetectable		 6dwdC-3hbuP:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		5 / 12 ASN P  98
PHE P  97
ASN P 135
PHE P  94
ILE P 190
 None
 1.26A 6dwnA-3hbuP:
undetectable		 6dwnA-3hbuP:
10.42