SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		3 / 3 ARG A  29
ASP A  53
ASN A  59
 None
 0.92A 1nbhA-3hbxA:
2.4		 1nbhA-3hbxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		3 / 3 ARG A  29
ASP A  53
ASN A  59
 None
 0.89A 1nbhD-3hbxA:
undetectable		 1nbhD-3hbxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 11 PHE A 108
GLY A 211
ASP A 262
ILE A 271
VAL A 243
 None
 1.19A 1phgA-3hbxA:
undetectable		 1phgA-3hbxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_B_ADNB1002_1
(CLASS B ACID
PHOSPHATASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 9 PHE A 314
GLU A 298
LEU A 296
TRP A 290
GLY A 134
 None
 1.42A 2b82B-3hbxA:
1.6		 2b82B-3hbxA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		3 / 3 ASP A 220
ASP A 191
ASN A 225
 None
 0.60A 2bm9D-3hbxA:
2.9		 2bm9D-3hbxA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		3 / 3 LYS A 278
ASP A 244
CYH A 166
 LLP  A 277 ( 3.2A)
LLP  A 277 ( 2.8A)
LLP  A 277 ( 4.0A)
 1.21A 2br4F-3hbxA:
2.6		 2br4F-3hbxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ASP A 244
ILE A 271
GLY A 249
ILE A 251
VAL A 221
 LLP  A 277 ( 2.8A)
None
None
None
None
 0.88A 2nnkA-3hbxA:
undetectable		 2nnkA-3hbxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 249
ALA A 245
ASP A 244
GLY A 286
ILE A 271
 None
None
LLP  A 277 ( 2.8A)
None
None
 0.88A 2o4sA-3hbxA:
undetectable		 2o4sA-3hbxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 7 ASN A 232
LEU A 228
VAL A 196
TRP A 237
 None
 1.17A 2uz2A-3hbxA:
undetectable		 2uz2A-3hbxA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 9 ILE A 204
PHE A 170
ALA A 171
VAL A 176
 None
 0.82A 2vufA-3hbxA:
undetectable		 2vufA-3hbxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ASP A 244
ILE A 271
GLY A 249
ILE A 251
VAL A 221
 LLP  A 277 ( 2.8A)
None
None
None
None
 0.91A 3el4A-3hbxA:
undetectable		 3el4A-3hbxA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 PHE A 425
ILE A 421
PHE A 378
VAL A 440
ILE A 437
 None
 1.08A 3em0B-3hbxA:
undetectable		 3em0B-3hbxA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 PHE A 254
GLY A 279
SER A 247
ILE A 285
THR A 123
 None
LLP  A 277 ( 4.4A)
LLP  A 277 ( 4.6A)
None
None
 1.24A 3iv6A-3hbxA:
undetectable		 3iv6A-3hbxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 316
PHE A 170
PHE A 314
VAL A 288
ALA A 136
 None
 1.17A 3nhxA-3hbxA:
undetectable		 3nhxA-3hbxA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ALA A 246
GLY A 249
TRP A 287
GLY A 211
HIS A 242
 LLP  A 277 ( 3.3A)
None
None
None
None
 1.02A 3ou6B-3hbxA:
undetectable		 3ou6B-3hbxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ALA A 246
GLY A 249
TRP A 287
GLY A 211
HIS A 242
 LLP  A 277 ( 3.3A)
None
None
None
None
 1.07A 3ou7B-3hbxA:
undetectable		 3ou7B-3hbxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 5 LEU A 259
LEU A 210
GLY A 211
GLY A 248
 None
 0.81A 3si7C-3hbxA:
undetectable
3si7D-3hbxA:
undetectable		 3si7C-3hbxA:
19.64
3si7D-3hbxA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 7 VAL A 367
ILE A 366
LEU A 433
LEU A 354
 None
 0.80A 4l1wA-3hbxA:
undetectable		 4l1wA-3hbxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 5 GLY A 216
SER A 212
PHE A 218
GLU A 219
 None
 1.04A 4m93B-3hbxA:
undetectable
4m93C-3hbxA:
undetectable		 4m93B-3hbxA:
17.64
4m93C-3hbxA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 TYR A 278
SER A 247
GLY A 275
ASP A 424
THR A  66
 LLP  A 277 ( 4.7A)
LLP  A 277 ( 4.6A)
LLP  A 277 ( 4.2A)
None
None
 1.36A 4mm4A-3hbxA:
undetectable		 4mm4A-3hbxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 6 LEU A 417
MET A 441
LEU A 380
ILE A 414
 None
 1.13A 4okxA-3hbxA:
undetectable		 4okxA-3hbxA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 4 ASN A 215
SER A 379
ALA A 377
VAL A 376
 None
 1.19A 4x1kC-3hbxA:
undetectable		 4x1kC-3hbxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 7 VAL A 367
ILE A 366
LEU A 433
LEU A 354
 None
 0.83A 4xo7A-3hbxA:
undetectable		 4xo7A-3hbxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 6 PHE A  63
SER A 274
ALA A 246
HIS A 276
 None
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 3.8A)
 1.15A 5dzkB-3hbxA:
undetectable
5dzkP-3hbxA:
undetectable		 5dzkB-3hbxA:
16.44
5dzkP-3hbxA:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 7 PHE A  63
SER A 274
ALA A 246
HIS A 276
 None
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 3.8A)
 1.15A 5dzkD-3hbxA:
undetectable
5dzkR-3hbxA:
undetectable		 5dzkD-3hbxA:
16.44
5dzkR-3hbxA:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 6 PHE A  63
SER A 274
ALA A 246
HIS A 276
 None
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 3.8A)
 1.15A 5dzkg-3hbxA:
undetectable
5dzku-3hbxA:
undetectable		 5dzkg-3hbxA:
16.44
5dzku-3hbxA:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 5 ILE A  76
GLN A 331
CYH A  72
GLU A  69
 None
 1.31A 5fseC-3hbxA:
undetectable		 5fseC-3hbxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 10 GLY A 211
GLY A 248
LEU A 210
LEU A 259
TYR A 256
 None
 1.23A 5hwkA-3hbxA:
undetectable		 5hwkA-3hbxA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 10 GLY A 211
GLY A 248
LEU A 210
LEU A 259
TYR A 256
 None
 1.22A 5hwkB-3hbxA:
undetectable		 5hwkB-3hbxA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 5 HIS A 276
ALA A 246
SER A 274
GLY A 125
 LLP  A 277 ( 3.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.2A)
 1.27A 5yodD-3hbxA:
undetectable		 5yodD-3hbxA:
19.13