SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 HIS A 216
HIS A 192
PHE A 166
HIS A 217
ASP A 152
 FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
None
FE  A 305 (-3.3A)
FE  A 306 ( 2.5A)
 1.24A 1a4lC-3hc1A:
undetectable		 1a4lC-3hc1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 HIS A 216
HIS A 192
PHE A 247
HIS A 217
ASP A 152
 FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
None
FE  A 305 (-3.3A)
FE  A 306 ( 2.5A)
 1.00A 1a4lC-3hc1A:
undetectable		 1a4lC-3hc1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ASP A 152
HIS A 151
HIS A 216
HIS A 121
 FE  A 306 ( 2.5A)
FE  A 306 (-3.5A)
FE  A 305 (-3.4A)
FE  A 306 (-3.4A)
 0.66A 1ei6D-3hc1A:
undetectable		 1ei6D-3hc1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 LEU A 260
VAL A 125
ALA A 129
ILE A 128
ILE A 291
 None
 1.02A 1epbB-3hc1A:
undetectable		 1epbB-3hc1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 LEU A 105
LEU A 149
LEU A 205
LEU A  66
 GOL  A 312 (-4.3A)
None
None
None
 0.81A 1errA-3hc1A:
1.9		 1errA-3hc1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 LEU A  71
TYR A  72
GLU A 293
ILE A 294
GLU A 134
 GOL  A 311 (-4.7A)
GOL  A 311 (-3.9A)
None
None
GOL  A 311 (-3.5A)
 1.24A 1mrqA-3hc1A:
undetectable		 1mrqA-3hc1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.26A 1v7zA-3hc1A:
undetectable		 1v7zA-3hc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.26A 1v7zB-3hc1A:
undetectable		 1v7zB-3hc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.26A 1v7zC-3hc1A:
undetectable		 1v7zC-3hc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.26A 1v7zD-3hc1A:
undetectable		 1v7zD-3hc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.26A 1v7zE-3hc1A:
undetectable		 1v7zE-3hc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.26A 1v7zF-3hc1A:
undetectable		 1v7zF-3hc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 PHE A 197
CYH A 210
TYR A 224
TYR A 215
 None
 1.20A 1xqlA-3hc1A:
undetectable
1xqlB-3hc1A:
undetectable		 1xqlA-3hc1A:
23.70
1xqlB-3hc1A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 GLU A 207
PHE A 197
VAL A 230
TYR A 215
 None
 1.06A 2fl5E-3hc1A:
undetectable
2fl5F-3hc1A:
undetectable		 2fl5E-3hc1A:
21.04
2fl5F-3hc1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 TYR A  72
LEU A  88
ALA A 101
CYH A 100
TYR A 145
 GOL  A 311 (-3.9A)
None
None
None
None
 1.15A 2g70A-3hc1A:
undetectable		 2g70A-3hc1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 HIS A 192
PHE A 247
HIS A 216
HIS A 151
SER A 122
 FE  A 305 (-3.5A)
None
FE  A 305 (-3.4A)
FE  A 306 (-3.5A)
None
 1.37A 2pgfA-3hc1A:
undetectable		 2pgfA-3hc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 HIS A 192
PHE A 247
HIS A 217
SER A 122
ASP A 152
 FE  A 305 (-3.5A)
None
FE  A 305 (-3.3A)
None
FE  A 306 ( 2.5A)
 1.27A 2pgfA-3hc1A:
undetectable		 2pgfA-3hc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 HIS A 216
HIS A 192
PHE A 247
HIS A 217
ASP A 152
 FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
None
FE  A 305 (-3.3A)
FE  A 306 ( 2.5A)
 0.98A 2pgrA-3hc1A:
undetectable		 2pgrA-3hc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 ILE A  97
ILE A  81
LEU A 123
 None
 0.49A 2prgA-3hc1A:
undetectable		 2prgA-3hc1A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 HIS A 216
ASP A 237
HIS A 192
ASP A 152
 FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.5A)
FE  A 306 ( 2.5A)
 0.95A 2xadA-3hc1A:
undetectable		 2xadA-3hc1A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 HIS A 216
ASP A 237
HIS A 192
ASP A 152
 FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.5A)
FE  A 306 ( 2.5A)
 0.97A 2xadB-3hc1A:
undetectable		 2xadB-3hc1A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 HIS A 216
ASP A 237
HIS A 192
ASP A 152
 FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.5A)
FE  A 306 ( 2.5A)
 0.95A 2xadC-3hc1A:
undetectable		 2xadC-3hc1A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 HIS A 216
ASP A 237
HIS A 192
ASP A 152
 FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.5A)
FE  A 306 ( 2.5A)
 0.97A 2xadD-3hc1A:
undetectable		 2xadD-3hc1A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.22A 3a6jA-3hc1A:
undetectable		 3a6jA-3hc1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 7 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.22A 3a6jB-3hc1A:
undetectable		 3a6jB-3hc1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.22A 3a6jC-3hc1A:
undetectable		 3a6jC-3hc1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.23A 3a6jE-3hc1A:
undetectable		 3a6jE-3hc1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 8 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.23A 3a6jF-3hc1A:
undetectable		 3a6jF-3hc1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 ASP A 174
PHE A 180
SER A 167
 None
 0.96A 3i5uB-3hc1A:
undetectable		 3i5uB-3hc1A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 VAL A 146
ILE A  35
GLY A  37
ALA A  36
LEU A 205
 None
 1.13A 3n8yA-3hc1A:
undetectable		 3n8yA-3hc1A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 4 SER A 265
GLY A 148
GLU A  95
 None
None
GOL  A 311 (-3.5A)
 0.69A 3raeA-3hc1A:
undetectable
3raeC-3hc1A:
undetectable		 3raeA-3hc1A:
22.00
3raeC-3hc1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 HIS A 217
HIS A 216
ASP A 237
HIS A 192
HIS A 121
 FE  A 305 (-3.3A)
FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.5A)
FE  A 306 (-3.4A)
 1.14A 4c1dB-3hc1A:
undetectable		 4c1dB-3hc1A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 HIS A 217
HIS A 216
ASP A 237
HIS A 192
HIS A 121
 FE  A 305 (-3.3A)
FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.5A)
FE  A 306 (-3.4A)
 1.21A 4c1fA-3hc1A:
undetectable
4c1fB-3hc1A:
undetectable		 4c1fA-3hc1A:
22.40
4c1fB-3hc1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 HIS A 217
HIS A 216
ASP A 237
HIS A 192
HIS A 121
 FE  A 305 (-3.3A)
FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.5A)
FE  A 306 (-3.4A)
 1.13A 4c1hA-3hc1A:
undetectable		 4c1hA-3hc1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ILE A 128
HIS A 250
LEU A 259
LEU A 260
 None
 0.89A 4l1wA-3hc1A:
undetectable		 4l1wA-3hc1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 PHE A 247
VAL A 173
ASP A 174
ALA A 183
 None
 0.79A 4m48A-3hc1A:
undetectable		 4m48A-3hc1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 ASP A 152
ALA A 129
GLY A 246
SER A 122
GLY A 124
 FE  A 306 ( 2.5A)
None
None
None
None
 1.06A 4mm9A-3hc1A:
undetectable		 4mm9A-3hc1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ASP A 152
ALA A 129
GLY A 246
SER A 122
GLY A 124
 FE  A 306 ( 2.5A)
None
None
None
None
 1.17A 4mmdB-3hc1A:
undetectable		 4mmdB-3hc1A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 ASP A 152
ALA A 129
GLY A 246
SER A 122
GLY A 124
 FE  A 306 ( 2.5A)
None
None
None
None
 1.14A 4mmeA-3hc1A:
undetectable		 4mmeA-3hc1A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 ASP A 152
ALA A 129
GLY A 246
SER A 122
GLY A 124
 FE  A 306 ( 2.5A)
None
None
None
None
 1.16A 4mmeB-3hc1A:
undetectable		 4mmeB-3hc1A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 6 HIS A 151
HIS A 121
HIS A 192
HIS A 216
ASP A 237
 FE  A 306 (-3.5A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
 1.04A 4ubpC-3hc1A:
undetectable		 4ubpC-3hc1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 7 ILE A 128
HIS A 250
LEU A 259
LEU A 260
 None
 0.93A 4xo7A-3hc1A:
undetectable		 4xo7A-3hc1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 LEU A 149
GLU A  95
GLY A 148
VAL A 233
LEU A 123
 None
GOL  A 311 (-3.5A)
None
None
None
 1.32A 5jo9A-3hc1A:
undetectable		 5jo9A-3hc1A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 ALA A  96
ILE A  97
ILE A  81
ALA A  50
LEU A  53
 None
 0.74A 5mvmA-3hc1A:
undetectable
5mvmE-3hc1A:
undetectable		 5mvmA-3hc1A:
15.41
5mvmE-3hc1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ILE A  81
ALA A  50
ALA A  96
ILE A  97
 None
 0.41A 5mvmA-3hc1A:
undetectable
5mvmB-3hc1A:
undetectable		 5mvmA-3hc1A:
15.41
5mvmB-3hc1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ILE A  81
ALA A  50
LEU A  53
ILE A  97
 None
 0.69A 5mvmB-3hc1A:
undetectable
5mvmC-3hc1A:
undetectable		 5mvmB-3hc1A:
15.41
5mvmC-3hc1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 ILE A  81
ALA A  50
LEU A  53
ALA A  96
ILE A  97
 None
 0.68A 5mvmD-3hc1A:
undetectable
5mvmE-3hc1A:
undetectable		 5mvmD-3hc1A:
15.41
5mvmE-3hc1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ASP A 152
HIS A 216
HIS A 192
HIS A 121
 FE  A 306 ( 2.5A)
FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
FE  A 306 (-3.4A)
 0.91A 5ncdA-3hc1A:
undetectable
5ncdD-3hc1A:
undetectable		 5ncdA-3hc1A:
21.86
5ncdD-3hc1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ASP A 152
HIS A 216
HIS A 192
HIS A 121
 FE  A 306 ( 2.5A)
FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
FE  A 306 (-3.4A)
 0.93A 5ncdB-3hc1A:
undetectable
5ncdC-3hc1A:
undetectable		 5ncdB-3hc1A:
21.86
5ncdC-3hc1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ASP A 152
HIS A 216
HIS A 192
HIS A 121
 FE  A 306 ( 2.5A)
FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
FE  A 306 (-3.4A)
 0.96A 5nekB-3hc1A:
undetectable		 5nekB-3hc1A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 ASP A 152
HIS A 216
HIS A 192
HIS A 121
 FE  A 306 ( 2.5A)
FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
FE  A 306 (-3.4A)
 0.93A 5nekD-3hc1A:
undetectable		 5nekD-3hc1A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 ASP A 152
HIS A 216
HIS A 192
HIS A 121
 FE  A 306 ( 2.5A)
FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
FE  A 306 (-3.4A)
 0.90A 5nelA-3hc1A:
undetectable
5nelD-3hc1A:
undetectable		 5nelA-3hc1A:
21.86
5nelD-3hc1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 10 HIS A 151
HIS A 121
HIS A 216
ASP A 237
HIS A 217
 FE  A 306 (-3.5A)
FE  A 306 (-3.4A)
FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.3A)
 1.05A 5nzwA-3hc1A:
undetectable		 5nzwA-3hc1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 9 LEU A 301
VAL A  63
LEU A  66
ILE A 102
LEU A 304
 None
 1.32A 5og9A-3hc1A:
1.9		 5og9A-3hc1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 ALA A 126
HIS A 263
VAL A 268
ILE A 269
THR A 136
 None
 1.34A 5y80A-3hc1A:
0.6		 5y80A-3hc1A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 11 GLU A 134
GLY A 124
ALA A 126
ILE A 294
VAL A 298
 GOL  A 311 (-3.5A)
None
None
None
None
 1.21A 5yk2A-3hc1A:
1.2		 5yk2A-3hc1A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		3 / 3 HIS A 217
HIS A 216
HIS A 192
 FE  A 305 (-3.3A)
FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
 0.52A 5zrdA-3hc1A:
undetectable		 5zrdA-3hc1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 LEU A 118
GLY A 154
PHE A 166
ASN A 159
VAL A 170
 None
 1.30A 6a94A-3hc1A:
undetectable		 6a94A-3hc1A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN
(Geobacter
sulfurreducens) 		4 / 5 VAL A  32
LEU A 150
VAL A 156
LEU A 199
 None
 0.95A 6bqgA-3hc1A:
2.3		 6bqgA-3hc1A:
12.83