SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N
(Homo
sapiens) 		4 / 7 TYR B  62
ILE B  90
GLU B  11
LEU B  56
 None
 0.85A 1j96B-3hcuB:
undetectable		 1j96B-3hcuB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N
(Homo
sapiens) 		5 / 12 LEU B  91
ILE B   8
ILE B 101
VAL B 104
LEU B 105
 None
 1.00A 3w68D-3hcuB:
undetectable		 3w68D-3hcuB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N
(Homo
sapiens) 		4 / 8 ILE B 101
ILE B   8
ALA B  32
PRO B  67
 None
 0.75A 4jltA-3hcuB:
undetectable		 4jltA-3hcuB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N
(Homo
sapiens) 		4 / 6 LEU B  54
LEU B  91
PHE B  71
LEU B 111
 None
 0.88A 5gs4A-3hcuB:
undetectable		 5gs4A-3hcuB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3hcu UBIQUITIN-CONJUGATIN
G ENZYME E2 N
(Homo
sapiens) 		4 / 5 LEU B  54
LEU B  91
PHE B  71
LEU B 111
 None
 0.84A 5gtrA-3hcuB:
undetectable		 5gtrA-3hcuB:
20.82