SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		5 / 12 ASN A 173
ASP A 252
PRO A  77
PHE A 279
SER A 282
 GOL  A 349 (-3.2A)
GOL  A 348 (-3.6A)
None
None
None
 1.05A 1g60A-3hcwA:
2.4		 1g60A-3hcwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		5 / 12 ILE A 326
ASP A 200
ILE A 149
LEU A 302
PRO A 299
 None
 1.11A 1jolB-3hcwA:
undetectable		 1jolB-3hcwA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		5 / 11 ILE A 147
ALA A 306
GLY A 303
ASN A 165
HIS A 162
 None
None
None
GOL  A   1 (-3.8A)
None
 1.44A 1n6cA-3hcwA:
undetectable		 1n6cA-3hcwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		5 / 12 ILE A 189
SER A 336
ILE A 270
LEU A 263
ILE A 248
 None
 0.97A 1rb3B-3hcwA:
undetectable		 1rb3B-3hcwA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		5 / 12 ILE A 249
ALA A 247
ARG A 339
LEU A 331
ILE A 333
 None
 1.18A 1y0xX-3hcwA:
undetectable		 1y0xX-3hcwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		4 / 6 ASN A 173
SER A 171
ALA A 170
ASP A 166
 GOL  A 349 (-3.2A)
None
None
None
 1.38A 3aruA-3hcwA:
undetectable		 3aruA-3hcwA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		3 / 3 GLU A 206
TYR A 216
SER A 210
 None
 0.99A 4at0A-3hcwA:
undetectable		 4at0A-3hcwA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		4 / 7 ILE A 189
LEU A 255
LYS A 199
GLY A 193
 None
 1.04A 4hajA-3hcwA:
undetectable		 4hajA-3hcwA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		5 / 12 LEU A 263
GLU A 265
LEU A 229
ILE A 248
ILE A 189
 None
 1.23A 4j24B-3hcwA:
undetectable		 4j24B-3hcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR
(Staphylococcus
aureus) 		5 / 12 LEU A  64
LEU A 127
ILE A 125
ILE A 147
ILE A 163
 None
 0.68A 4y0rA-3hcwA:
undetectable		 4y0rA-3hcwA:
19.93