SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		5 / 10 ALA A  11
ILE A 126
ALA A  36
LEU A  24
PHE A 105
 None
 1.16A 1xp0A-3hcyA:
undetectable		 1xp0A-3hcyA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 5 VAL A  69
ASN A  68
VAL A  83
ILE A  87
 None
 0.92A 1z2bC-3hcyA:
undetectable		 1z2bC-3hcyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		5 / 10 LEU A  25
ILE A 134
ARG A 138
PRO A  61
GLY A  99
 None
 1.34A 2qd4B-3hcyA:
undetectable		 2qd4B-3hcyA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.09A 3dqtA-3hcyA:
undetectable
3dqtB-3hcyA:
undetectable		 3dqtA-3hcyA:
18.07
3dqtB-3hcyA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		5 / 10 LEU A  25
ILE A 134
ARG A 138
PRO A  61
GLY A  99
 None
 1.22A 3hcpB-3hcyA:
0.0		 3hcpB-3hcyA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 SER A  81
VAL A  83
PHE A  74
GLU A  80
 None
 1.04A 3n5tA-3hcyA:
undetectable
3n5tB-3hcyA:
undetectable		 3n5tA-3hcyA:
17.61
3n5tB-3hcyA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.04A 3n61A-3hcyA:
undetectable
3n61B-3hcyA:
undetectable		 3n61A-3hcyA:
20.29
3n61B-3hcyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 8 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.01A 3nlrA-3hcyA:
undetectable
3nlrB-3hcyA:
undetectable		 3nlrA-3hcyA:
20.29
3nlrB-3hcyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		3 / 3 HIS A 113
ARG A 114
GLU A 119
 None
 1.08A 3qf1A-3hcyA:
undetectable		 3qf1A-3hcyA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.09A 4k5jA-3hcyA:
undetectable
4k5jB-3hcyA:
undetectable		 4k5jA-3hcyA:
18.18
4k5jB-3hcyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.08A 5adlA-3hcyA:
undetectable
5adlB-3hcyA:
undetectable		 5adlA-3hcyA:
18.18
5adlB-3hcyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.08A 5fj3A-3hcyA:
undetectable
5fj3B-3hcyA:
undetectable		 5fj3A-3hcyA:
18.18
5fj3B-3hcyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ILE A  82
LEU A  90
VAL A  83
GLY A  86
ASP A 110
 None
 1.19A 5nnaA-3hcyA:
undetectable		 5nnaA-3hcyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ILE A  82
LEU A  90
VAL A  83
GLY A  86
ASP A 110
 None
 1.21A 5nnaB-3hcyA:
undetectable		 5nnaB-3hcyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ILE A  82
LEU A  90
VAL A  83
GLY A  86
ASP A 110
 None
 1.20A 5nnaC-3hcyA:
undetectable		 5nnaC-3hcyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ILE A  82
LEU A  90
VAL A  83
GLY A  86
ASP A 110
 None
 1.18A 5nnaD-3hcyA:
undetectable		 5nnaD-3hcyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.10A 5vv7A-3hcyA:
undetectable
5vv7B-3hcyA:
undetectable		 5vv7A-3hcyA:
18.18
5vv7B-3hcyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.05A 5vvnA-3hcyA:
undetectable
5vvnB-3hcyA:
undetectable		 5vvnA-3hcyA:
18.18
5vvnB-3hcyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 SER A  81
VAL A  83
PHE A  74
GLU A  80
 None
 1.14A 6av6A-3hcyA:
undetectable
6av6B-3hcyA:
undetectable		 6av6A-3hcyA:
21.19
6av6B-3hcyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 PHE A  74
GLU A  80
SER A  81
VAL A  83
 None
 1.10A 6av6C-3hcyA:
undetectable
6av6D-3hcyA:
undetectable		 6av6C-3hcyA:
21.19
6av6D-3hcyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 SER A  81
VAL A  83
PHE A  74
GLU A  80
 None
 1.15A 6av7A-3hcyA:
undetectable
6av7B-3hcyA:
undetectable		 6av7A-3hcyA:
21.19
6av7B-3hcyA:
21.19