SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE
(Cytophaga
hutchinsonii) 		5 / 12 LEU A 352
LEU A 340
ASN A 339
ARG A 400
LEU A 418
 None
None
SO4  A   1 (-4.9A)
SO4  A   5 (-3.9A)
None
 1.40A 1a28B-3hczA:
undetectable		 1a28B-3hczA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 416
ASN A 419
TRP A 417
GLY A 415
 None
 0.92A 1dbbH-3hczA:
undetectable
1dbbL-3hczA:
undetectable		 1dbbH-3hczA:
17.41
1dbbL-3hczA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE
(Cytophaga
hutchinsonii) 		3 / 3 ARG A 350
ASN A 447
THR A 360
 None
 0.78A 2q63A-3hczA:
undetectable		 2q63A-3hczA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE
(Cytophaga
hutchinsonii) 		5 / 11 ILE A 455
GLU A 375
ILE A 391
LEU A 464
VAL A 443
 None
 1.12A 3n0hA-3hczA:
undetectable		 3n0hA-3hczA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE
(Cytophaga
hutchinsonii) 		5 / 12 ILE A 455
GLU A 375
ILE A 391
LEU A 464
VAL A 443
 None
 1.11A 3s3vA-3hczA:
undetectable		 3s3vA-3hczA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE
(Cytophaga
hutchinsonii) 		4 / 6 VAL A 355
VAL A 420
ILE A 398
PHE A 429
 None
 1.06A 5jw1B-3hczA:
undetectable		 5jw1B-3hczA:
14.55