SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hd6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 8 PHE A 130
SER A 240
ILE A 239
LEU A 170
 None
 0.70A 1eupA-3hd6A:
0.0		 1eupA-3hd6A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 11 PHE A  74
ALA A 133
VAL A 412
LEU A 161
HIS A 344
 None
 1.34A 1hbpA-3hd6A:
undetectable		 1hbpA-3hd6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		3 / 3 ALA A 259
VAL A 261
TRP A 229
 None
 0.75A 1nt6A-3hd6A:
undetectable		 1nt6A-3hd6A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		3 / 3 ALA A 259
VAL A 261
TRP A 229
 None
 0.76A 1nt6B-3hd6A:
undetectable		 1nt6B-3hd6A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 8 GLY A 351
VAL A 354
SER A 181
ILE A 350
 None
 0.69A 1pk7B-3hd6A:
undetectable		 1pk7B-3hd6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 6 PRO A 439
MET A 438
ALA A 433
GLU A 431
 None
 1.38A 1qhyA-3hd6A:
undetectable		 1qhyA-3hd6A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 PHE A 311
GLY A 310
GLY A 289
ILE A 267
SER A 317
 None
 0.94A 1v2xA-3hd6A:
undetectable		 1v2xA-3hd6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 PHE A 311
GLY A 310
GLY A 289
ILE A 267
VAL A 312
 None
None
None
None
BOG  A 501 ( 4.4A)
 0.94A 1v2xA-3hd6A:
undetectable		 1v2xA-3hd6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 6 ARG A 210
SER A 207
THR A   5
ALA A 433
 None
 0.92A 1w0gA-3hd6A:
0.0		 1w0gA-3hd6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 8 TYR A  84
CYH A 429
ARG A 201
TYR A 435
 None
 1.21A 1xqlA-3hd6A:
undetectable
1xqlB-3hd6A:
undetectable		 1xqlA-3hd6A:
22.03
1xqlB-3hd6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 8 ARG A 201
TYR A 435
TYR A  84
CYH A 429
 None
 1.20A 1xqlA-3hd6A:
undetectable
1xqlB-3hd6A:
undetectable		 1xqlA-3hd6A:
22.03
1xqlB-3hd6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 10 GLY A 290
GLY A 294
THR A 295
ALA A 296
ALA A 297
 None
 1.09A 2ej3B-3hd6A:
undetectable		 2ej3B-3hd6A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 9 LEU A 332
ILE A 340
GLY A 345
ILE A 346
ILE A 334
 None
 1.15A 2r5qA-3hd6A:
undetectable		 2r5qA-3hd6A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 9 LEU A 332
ILE A 340
GLY A 345
ILE A 346
ILE A 334
 None
 1.15A 2r5qC-3hd6A:
undetectable		 2r5qC-3hd6A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 6 THR A 160
VAL A 159
GLU A 166
CYH A 131
 None
 1.22A 3b6rB-3hd6A:
undetectable		 3b6rB-3hd6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 6 GLY A 289
ALA A 292
LEU A 343
PRO A 347
 None
 0.98A 3bgdA-3hd6A:
undetectable		 3bgdA-3hd6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 8 GLY A 289
VAL A 291
LEU A 343
PRO A 347
 None
 1.03A 3bgdB-3hd6A:
undetectable		 3bgdB-3hd6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 GLY A 413
GLY A 192
GLY A 409
ASN A 342
ILE A 334
 None
 1.09A 3eluA-3hd6A:
undetectable		 3eluA-3hd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 7 LEU A 402
TYR A 190
ILE A 410
ARG A 201
 None
 1.23A 3ik3A-3hd6A:
undetectable		 3ik3A-3hd6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 7 LEU A 402
TYR A 190
ILE A 410
ARG A 201
 None
 1.26A 3ik3B-3hd6A:
undetectable		 3ik3B-3hd6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		6 / 12 PHE A 311
GLY A 310
GLY A 289
ILE A 267
SER A 317
VAL A 312
 None
None
None
None
None
BOG  A 501 ( 4.4A)
 1.26A 3nk7B-3hd6A:
undetectable		 3nk7B-3hd6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 GLY A 310
GLY A 314
ALA A 306
LEU A 262
THR A 253
 None
 1.17A 3p2kB-3hd6A:
undetectable		 3p2kB-3hd6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 10 PHE A 187
ALA A 405
GLY A 409
ILE A 411
CYH A 131
 None
 1.06A 3qpsA-3hd6A:
0.8		 3qpsA-3hd6A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		3 / 3 PHE A 139
TYR A 435
TYR A  84
 None
 1.04A 4ffwA-3hd6A:
undetectable		 4ffwA-3hd6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 GLY A 352
GLY A 355
ILE A 350
ILE A 349
SER A 181
 None
 1.07A 4iv0B-3hd6A:
undetectable		 4iv0B-3hd6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 GLY A 352
GLY A 355
ILE A 350
ILE A 349
SER A 181
 None
 1.08A 4mwzA-3hd6A:
undetectable		 4mwzA-3hd6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		6 / 12 THR A 401
GLY A 345
GLY A 348
GLY A 352
LEU A 343
ALA A 189
 None
 1.41A 4uciA-3hd6A:
undetectable		 4uciA-3hd6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		6 / 12 THR A 401
GLY A 345
GLY A 348
GLY A 352
LEU A 343
ALA A 189
 None
 1.40A 4uciB-3hd6A:
undetectable		 4uciB-3hd6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 ASN A 342
ILE A 340
GLY A 192
ALA A 141
ASP A 336
 None
 1.19A 4xt8A-3hd6A:
undetectable		 4xt8A-3hd6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 7 TYR A 241
GLY A 180
THR A 183
LEU A 170
 None
 0.92A 4ze3A-3hd6A:
undetectable		 4ze3A-3hd6A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 5 TYR A 435
ARG A  10
ASN A   4
GLY A 422
 None
 1.44A 5bphB-3hd6A:
0.0		 5bphB-3hd6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 8 TYR A 241
GLY A 180
THR A 183
LEU A 170
 None
 0.90A 5esjA-3hd6A:
undetectable		 5esjA-3hd6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 PHE A 311
GLY A 314
VAL A 322
VAL A 265
ALA A 266
 None
 1.05A 5kocA-3hd6A:
undetectable		 5kocA-3hd6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 GLY A 339
GLY A 180
VAL A 291
ILE A 184
GLY A 192
 None
 0.95A 5koxA-3hd6A:
undetectable		 5koxA-3hd6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 6 LEU A 151
VAL A 146
LEU A 416
VAL A 142
 None
 0.95A 5x7zA-3hd6A:
0.2		 5x7zA-3hd6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		5 / 12 ALA A 288
PHE A  80
PHE A 430
TYR A  84
THR A 196
 None
 1.29A 6aycA-3hd6A:
undetectable		 6aycA-3hd6A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		3 / 3 ALA A 133
PHE A 162
GLN A 107
 None
 0.62A 6eceA-3hd6A:
undetectable		 6eceA-3hd6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 6 ARG A 210
SER A 207
THR A   5
ALA A 433
 None
 0.80A 6ma6A-3hd6A:
0.8		 6ma6A-3hd6A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens) 		4 / 6 THR A 263
LEU A 262
THR A 318
LEU A 257
 None
 1.11A 6mvxA-3hd6A:
undetectable
6mvxB-3hd6A:
1.9
6mvxC-3hd6A:
2.2		 6mvxA-3hd6A:
20.49
6mvxB-3hd6A:
20.49
6mvxC-3hd6A:
20.49