SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hdb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 6 TYR A 497
ASP A 604
VAL A 596
GLY A 594
 None
 1.26A 1ekjC-3hdbA:
undetectable
1ekjD-3hdbA:
undetectable		 1ekjC-3hdbA:
19.59
1ekjD-3hdbA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 6 ASP A 604
VAL A 596
GLY A 594
TYR A 497
 None
 1.22A 1ekjC-3hdbA:
undetectable
1ekjD-3hdbA:
undetectable		 1ekjC-3hdbA:
19.59
1ekjD-3hdbA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		5 / 10 GLY A 405
ASN A 229
ASP A 416
ASP A 429
ASN A 422
 2PE  A 652 ( 4.6A)
2PE  A 652 (-3.5A)
CA  A 622 (-3.3A)
None
None
 1.48A 1fpqA-3hdbA:
undetectable		 1fpqA-3hdbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 5 ASP A 319
ASP A 206
LEU A 288
ALA A 208
 None
 1.09A 1nh8A-3hdbA:
undetectable		 1nh8A-3hdbA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.14A 1os2A-3hdbA:
10.1		 1os2A-3hdbA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.14A 1os2D-3hdbA:
10.2		 1os2D-3hdbA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.23A 1uttA-3hdbA:
10.5		 1uttA-3hdbA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.18A 1utzA-3hdbA:
10.4		 1utzA-3hdbA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.21A 1utzB-3hdbA:
10.4		 1utzB-3hdbA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		5 / 6 ILE A 298
HIS A 333
GLU A 334
HIS A 337
HIS A 343
 None
ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.59A 1y93A-3hdbA:
10.6		 1y93A-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.14A 2hu6A-3hdbA:
10.4		 2hu6A-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 8 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.23A 2jihB-3hdbA:
26.2		 2jihB-3hdbA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 6 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.14A 2ow9A-3hdbA:
10.1		 2ow9A-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.18A 2ow9B-3hdbA:
10.0		 2ow9B-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.20A 2ozrC-3hdbA:
9.8		 2ozrC-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.20A 2ozrD-3hdbA:
9.9		 2ozrD-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.32A 2ozrE-3hdbA:
10.0		 2ozrE-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		3 / 3 HIS A 333
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.23A 2ozrF-3hdbA:
9.8		 2ozrF-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.17A 3kecA-3hdbA:
10.1		 3kecA-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		3 / 3 HIS A 333
GLU A 334
HIS A 337
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
 0.13A 3kecB-3hdbA:
9.9		 3kecB-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.13A 3likA-3hdbA:
10.6		 3likA-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.16A 3lilA-3hdbA:
10.6		 3lilA-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		5 / 5 ILE A 298
HIS A 333
GLU A 334
HIS A 337
HIS A 343
 None
ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.35A 3ljgA-3hdbA:
10.6		 3ljgA-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		5 / 5 ILE A 299
HIS A 333
GLU A 334
HIS A 337
HIS A 343
 None
ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 1.46A 3ljgA-3hdbA:
10.6		 3ljgA-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.11A 3lkaA-3hdbA:
10.4		 3lkaA-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		5 / 9 ILE A 298
ILE A 299
VAL A 262
ILE A 317
ILE A 316
 None
 1.27A 3p4wB-3hdbA:
undetectable		 3p4wB-3hdbA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 6 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.23A 4a7bA-3hdbA:
9.8		 4a7bA-3hdbA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 7 ASP A 416
ASN A 229
GLU A 233
GLU A 410
 CA  A 622 (-3.3A)
2PE  A 652 (-3.5A)
2PE  A 652 (-4.1A)
CA  A 622 (-3.3A)
 1.20A 4fevB-3hdbA:
undetectable		 4fevB-3hdbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 7 ASP A 416
ASN A 229
GLU A 233
GLU A 410
 CA  A 622 (-3.3A)
2PE  A 652 (-3.5A)
2PE  A 652 (-4.1A)
CA  A 622 (-3.3A)
 1.21A 4fewB-3hdbA:
undetectable		 4fewB-3hdbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		5 / 12 GLY A 358
ASP A 344
ILE A 356
ALA A 332
HIS A 337
 None
None
None
None
ZN  A 620 (-3.3A)
 1.30A 4wh5A-3hdbA:
undetectable		 4wh5A-3hdbA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.14A 5n5jA-3hdbA:
10.5		 5n5jA-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		5 / 5 ILE A 298
HIS A 333
GLU A 334
HIS A 337
HIS A 343
 None
ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.59A 5n5kA-3hdbA:
10.5		 5n5kA-3hdbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 5 PRO A 587
GLY A 588
THR A 589
LYS A 590
 None
 1.18A 5x23A-3hdbA:
undetectable		 5x23A-3hdbA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3hdb AAHIV
(Deinagkistrodon
acutus) 		4 / 6 PRO A 587
GLY A 588
THR A 589
LYS A 590
 None
 1.09A 5xxiA-3hdbA:
undetectable		 5xxiA-3hdbA:
20.12