SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hdc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hdc THIOREDOXIN FAMILY
PROTEIN
(Geobacter
metallireducens) 		3 / 3 ASN A  99
TRP A  67
GLN A 126
 None
 1.16A 1xoqA-3hdcA:
undetectable		 1xoqA-3hdcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3hdc THIOREDOXIN FAMILY
PROTEIN
(Geobacter
metallireducens) 		4 / 5 GLY A 130
PRO A  40
ALA A  39
ILE A 146
 None
 0.95A 2aofA-3hdcA:
undetectable		 2aofA-3hdcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3hdc THIOREDOXIN FAMILY
PROTEIN
(Geobacter
metallireducens) 		4 / 8 ILE A  61
TRP A 156
ILE A 139
ARG A 147
 None
 0.91A 3sfeB-3hdcA:
undetectable
3sfeC-3hdcA:
undetectable		 3sfeB-3hdcA:
19.01
3sfeC-3hdcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3hdc THIOREDOXIN FAMILY
PROTEIN
(Geobacter
metallireducens) 		4 / 6 PHE A 104
LEU A 118
ASN A  51
PRO A  45
 None
 1.44A 4yv5B-3hdcA:
undetectable		 4yv5B-3hdcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3hdc THIOREDOXIN FAMILY
PROTEIN
(Geobacter
metallireducens) 		4 / 6 PHE A 104
LEU A 118
ASN A  51
PRO A  45
 None
 1.45A 4yv5A-3hdcA:
undetectable		 4yv5A-3hdcA:
20.25