SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 LEU A 163
THR A  84
GLU A  49
HIS A  50
GLU A 126
 None
None
CO  A 500 ( 4.3A)
CO  A 500 (-3.4A)
CO  A 500 (-2.1A)
 1.34A 1kw0A-3hdiA:
undetectable		 1kw0A-3hdiA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.87A 1v7zA-3hdiA:
undetectable		 1v7zA-3hdiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.89A 1v7zB-3hdiA:
undetectable		 1v7zB-3hdiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.89A 1v7zC-3hdiA:
undetectable		 1v7zC-3hdiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.90A 1v7zD-3hdiA:
undetectable		 1v7zD-3hdiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.90A 1v7zE-3hdiA:
undetectable		 1v7zE-3hdiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.89A 1v7zF-3hdiA:
undetectable		 1v7zF-3hdiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 6 LEU A 269
GLY A 262
ASN A 258
ILE A 298
 None
 0.82A 1xf1B-3hdiA:
undetectable		 1xf1B-3hdiA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 ALA A  77
HIS A  50
GLU A  49
HIS A  46
GLU A 126
 None
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
CO  A 500 (-3.4A)
CO  A 500 (-2.1A)
 0.59A 2c6nA-3hdiA:
undetectable		 2c6nA-3hdiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		3 / 3 ARG A  35
SER A 151
TYR A 214
 None
 0.96A 2q2hA-3hdiA:
undetectable
2q2hB-3hdiA:
undetectable		 2q2hA-3hdiA:
16.19
2q2hB-3hdiA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		3 / 3 GLY A 153
TYR A 147
SER A 143
 None
 0.75A 2xatA-3hdiA:
undetectable		 2xatA-3hdiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		3 / 3 ARG A 120
GLU A  49
SER A 165
 None
CO  A 500 ( 4.3A)
None
 0.80A 2xkkA-3hdiA:
undetectable
2xkkC-3hdiA:
2.3		 2xkkA-3hdiA:
20.16
2xkkC-3hdiA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.87A 3a6jA-3hdiA:
undetectable		 3a6jA-3hdiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 7 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.85A 3a6jB-3hdiA:
undetectable		 3a6jB-3hdiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.86A 3a6jC-3hdiA:
undetectable		 3a6jC-3hdiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.87A 3a6jE-3hdiA:
undetectable		 3a6jE-3hdiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 8 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.85A 3a6jF-3hdiA:
undetectable		 3a6jF-3hdiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 5 LEU A 269
GLN A 315
THR A 317
LEU A 296
 None
 1.22A 3ce6D-3hdiA:
undetectable		 3ce6D-3hdiA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 10 LEU A 269
THR A 318
GLN A 315
THR A 317
LEU A 239
 None
 1.45A 3h9uA-3hdiA:
undetectable		 3h9uA-3hdiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		3 / 3 GLY A 405
PRO A 408
LEU A 400
 None
 0.60A 3hcpB-3hdiA:
undetectable		 3hcpB-3hdiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 ILE A 398
SER A 397
GLY A 240
SER A 143
THR A 146
 None
 1.12A 3r75A-3hdiA:
undetectable		 3r75A-3hdiA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 ILE A 398
SER A 397
GLY A 240
SER A 143
THR A 146
 None
 1.12A 3r75B-3hdiA:
undetectable		 3r75B-3hdiA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		3 / 3 ASP A 292
GLU A 217
GLY A 216
 None
 0.61A 3w9tA-3hdiA:
undetectable		 3w9tA-3hdiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 LEU A 269
LEU A 261
LEU A 392
ILE A 298
TYR A 241
 None
 1.13A 4a7aB-3hdiA:
undetectable		 4a7aB-3hdiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 7 LEU A 400
ALA A 235
LEU A 237
THR A 302
 None
 0.73A 4d7bA-3hdiA:
undetectable		 4d7bA-3hdiA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 11 ASP A 100
PHE A  67
ILE A  26
LYS A 199
ILE A 200
 None
 1.29A 4drjA-3hdiA:
undetectable		 4drjA-3hdiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 6 LEU A 400
ALA A 235
LEU A 237
THR A 302
 None
 0.80A 4ikiB-3hdiA:
undetectable		 4ikiB-3hdiA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 7 HIS A 150
PRO A 219
SER A  80
ASP A 292
 None
 1.14A 4odjA-3hdiA:
undetectable		 4odjA-3hdiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 6 LEU A 239
THR A 302
ALA A 300
SER A 285
 None
 0.88A 4pwjA-3hdiA:
undetectable		 4pwjA-3hdiA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 7 GLU A  37
THR A  79
GLY A  33
THR A  84
 None
 0.93A 4qwpB-3hdiA:
undetectable		 4qwpB-3hdiA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 LEU A 196
VAL A 188
PHE A  67
SER A  70
GLY A  72
 None
 1.25A 5f9zA-3hdiA:
undetectable		 5f9zA-3hdiA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 VAL A 311
GLN A 315
ALA A 300
SER A 319
LEU A 142
 None
 1.17A 5hv1A-3hdiA:
undetectable		 5hv1A-3hdiA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 LEU A 400
LEU A 142
ALA A 410
GLY A 301
ALA A 300
 None
 1.05A 5jw1B-3hdiA:
undetectable		 5jw1B-3hdiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 5 SER A  25
VAL A  24
GLY A 190
ALA A 189
 None
 1.08A 5k50A-3hdiA:
undetectable		 5k50A-3hdiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		4 / 6 LEU A 400
ALA A 235
LEU A 237
THR A 302
 None
 0.86A 5l4iA-3hdiA:
undetectable		 5l4iA-3hdiA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 GLY A 334
LEU A 321
LEU A 392
ASN A 258
LEU A 257
 None
 1.13A 5nfjB-3hdiA:
undetectable		 5nfjB-3hdiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 GLY A 334
LEU A 321
LEU A 392
ASN A 258
LEU A 257
 None
 1.13A 5nfjC-3hdiA:
undetectable		 5nfjC-3hdiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 SER A 264
LEU A 321
LEU A 392
ASN A 258
LEU A 257
 None
 1.10A 5nfjC-3hdiA:
undetectable		 5nfjC-3hdiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3hdi PROCESSING PROTEASE
(Bacillus
halodurans) 		5 / 12 LEU A 269
THR A 318
GLN A 315
THR A 317
LEU A 239
 None
 1.46A 6exiC-3hdiA:
undetectable		 6exiC-3hdiA:
12.95