SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		7 / 12 GLY A 105
VAL A 112
ALA A 125
VAL A 160
ASN A 227
LEU A 229
THR A 239
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
GMG  A   1 (-3.8A)
 0.64A 1fmoE-3hdnA:
25.0		 1fmoE-3hdnA:
39.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		4 / 5 LEU A 230
GLY A 234
HIS A 235
ILE A 236
 None
 0.89A 1xf1A-3hdnA:
undetectable		 1xf1A-3hdnA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 11 HIS A 214
THR A 277
ARG A 339
VAL A 219
ASP A 275
 None
 1.39A 2a5hA-3hdnA:
0.0		 2a5hA-3hdnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 12 HIS A 214
THR A 277
ARG A 339
VAL A 219
ASP A 275
 None
 1.39A 2a5hB-3hdnA:
0.0		 2a5hB-3hdnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 12 HIS A 214
THR A 277
ARG A 339
VAL A 219
ASP A 275
 None
 1.39A 2a5hC-3hdnA:
undetectable		 2a5hC-3hdnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 12 HIS A 214
THR A 277
ARG A 339
VAL A 219
ASP A 275
 None
 1.39A 2a5hD-3hdnA:
0.0		 2a5hD-3hdnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		4 / 7 ILE A 228
LEU A 184
PHE A 185
TYR A 263
 None
 1.06A 2zxwN-3hdnA:
undetectable
2zxwW-3hdnA:
undetectable		 2zxwN-3hdnA:
20.50
2zxwW-3hdnA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		4 / 5 GLN A 167
PHE A 166
LEU A 162
PHE A 241
 None
 1.27A 3ablC-3hdnA:
2.3
3ablJ-3hdnA:
undetectable		 3ablC-3hdnA:
22.31
3ablJ-3hdnA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		8 / 12 GLY A 105
GLY A 107
GLY A 110
VAL A 112
ALA A 125
LYS A 127
TYR A 178
LEU A 229
 None
GMG  A   1 (-3.3A)
None
None
GMG  A   1 (-3.4A)
GMG  A   1 (-3.0A)
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
 0.73A 3fupA-3hdnA:
19.9		 3fupA-3hdnA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 12 TYR A 292
ILE A 228
TYR A 263
PHE A 194
GLU A 289
 None
 1.41A 3q5pA-3hdnA:
undetectable		 3q5pA-3hdnA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 11 TYR A 292
ILE A 228
TYR A 263
PHE A 194
GLU A 289
 None
 1.41A 3q5rA-3hdnA:
undetectable		 3q5rA-3hdnA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		3 / 3 LYS A 366
SER A 232
GLN A 233
 None
 1.09A 3si7A-3hdnA:
undetectable		 3si7A-3hdnA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		4 / 5 LEU A 151
GLY A 242
PHE A 241
PHE A 174
 None
 1.16A 3smtA-3hdnA:
undetectable		 3smtA-3hdnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		6 / 12 ILE A 104
GLY A 107
GLY A 110
VAL A 112
ALA A 125
VAL A 160
 GMG  A   1 (-4.3A)
GMG  A   1 (-3.3A)
None
None
GMG  A   1 (-3.4A)
None
 0.78A 3v5wA-3hdnA:
10.9		 3v5wA-3hdnA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		6 / 11 GLY A 105
GLY A 107
VAL A 112
ALA A 125
TYR A 178
LEU A 229
 None
GMG  A   1 (-3.3A)
None
GMG  A   1 (-3.4A)
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
 0.86A 4ckiA-3hdnA:
15.5		 4ckiA-3hdnA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		7 / 12 GLY A 105
VAL A 112
ALA A 125
LEU A 162
GLY A 182
GLU A 183
LEU A 229
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.0A)
None
GMG  A   1 ( 4.9A)
 0.84A 4ifgA-3hdnA:
24.7		 4ifgA-3hdnA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		4 / 6 LEU A 230
TYR A 186
PRO A 374
GLU A 191
 None
 1.33A 4z4gA-3hdnA:
undetectable		 4z4gA-3hdnA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 9 LEU A 328
LEU A 283
GLY A 284
LEU A 287
ALA A 203
 None
 1.04A 5dqfA-3hdnA:
undetectable		 5dqfA-3hdnA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 7 GLY A 105
GLY A 107
SER A 108
PHE A 109
GLU A 183
 None
GMG  A   1 (-3.3A)
None
None
None
 1.00A 5izfA-3hdnA:
24.6		 5izfA-3hdnA:
38.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 7 GLY A 105
GLY A 107
SER A 108
GLY A 110
LEU A 129
 None
GMG  A   1 (-3.3A)
None
None
None
 1.16A 5izjB-3hdnA:
28.5		 5izjB-3hdnA:
38.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		7 / 11 GLY A 105
VAL A 112
ALA A 125
LEU A 176
TYR A 178
GLU A 183
LEU A 229
 None
None
GMG  A   1 (-3.4A)
GMG  A   1 (-4.5A)
GMG  A   1 ( 4.9A)
None
GMG  A   1 ( 4.9A)
 0.63A 5lvnA-3hdnA:
28.4		 5lvnA-3hdnA:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		7 / 11 GLY A 105
VAL A 112
ALA A 125
VAL A 160
LEU A 176
TYR A 178
GLU A 183
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 (-4.5A)
GMG  A   1 ( 4.9A)
None
 0.75A 5lvnA-3hdnA:
28.4		 5lvnA-3hdnA:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		6 / 10 VAL A 112
ALA A 125
VAL A 160
TYR A 178
LEU A 229
THR A 239
 None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
GMG  A   1 (-3.8A)
 0.76A 5n3hA-3hdnA:
29.6		 5n3hA-3hdnA:
39.37