SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hdo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 9 GLU A 188
ARG A 208
LEU A 261
ALA A 254
LEU A 255
 None
 1.47A 1mj2C-3hdoA:
undetectable		 1mj2C-3hdoA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 9 GLU A 188
ARG A 208
LEU A 261
ALA A 254
LEU A 255
 None
 1.46A 1mjoA-3hdoA:
undetectable		 1mjoA-3hdoA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 9 GLU A 188
ARG A 208
LEU A 261
ALA A 254
LEU A 255
 None
 1.46A 1mjoB-3hdoA:
undetectable		 1mjoB-3hdoA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 9 GLU A 188
ARG A 208
LEU A 261
ALA A 254
LEU A 255
 None
 1.47A 1mjoC-3hdoA:
undetectable		 1mjoC-3hdoA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A 109
GLY A 118
ILE A 107
GLU A 106
 None
 0.82A 1mrjA-3hdoA:
undetectable		 1mrjA-3hdoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 12 VAL A 306
LEU A 310
LEU A 279
LEU A 346
LEU A 294
 None
 1.23A 1mx1C-3hdoA:
undetectable		 1mx1C-3hdoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A  76
CYH A 251
LEU A 243
MET A  85
 None
 1.32A 1uw6A-3hdoA:
undetectable
1uw6B-3hdoA:
undetectable		 1uw6A-3hdoA:
19.38
1uw6B-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A  76
THR A 209
CYH A 251
MET A  85
 None
 1.04A 1uw6A-3hdoA:
undetectable
1uw6B-3hdoA:
undetectable		 1uw6A-3hdoA:
19.38
1uw6B-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A  76
CYH A 251
LEU A 243
MET A  85
 None
 1.29A 1uw6D-3hdoA:
undetectable
1uw6E-3hdoA:
undetectable		 1uw6D-3hdoA:
19.38
1uw6E-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A  76
THR A 209
CYH A 251
MET A  85
 None
 1.07A 1uw6D-3hdoA:
undetectable
1uw6E-3hdoA:
undetectable		 1uw6D-3hdoA:
19.38
1uw6E-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A  76
CYH A 251
LEU A 243
MET A  85
 None
 1.31A 1uw6G-3hdoA:
undetectable
1uw6H-3hdoA:
undetectable		 1uw6G-3hdoA:
19.38
1uw6H-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A  76
THR A 209
CYH A 251
MET A  85
 None
 1.03A 1uw6G-3hdoA:
undetectable
1uw6H-3hdoA:
undetectable		 1uw6G-3hdoA:
19.38
1uw6H-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A  76
CYH A 251
LEU A 243
MET A  85
 None
 1.32A 1uw6P-3hdoA:
undetectable
1uw6Q-3hdoA:
undetectable		 1uw6P-3hdoA:
19.38
1uw6Q-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 TYR A  76
THR A 209
CYH A 251
MET A  85
 None
 1.03A 1uw6P-3hdoA:
undetectable
1uw6Q-3hdoA:
undetectable		 1uw6P-3hdoA:
19.38
1uw6Q-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 LEU A 243
MET A  85
TYR A  76
CYH A 251
 None
 1.30A 1uw6P-3hdoA:
undetectable
1uw6T-3hdoA:
undetectable		 1uw6P-3hdoA:
19.38
1uw6T-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 MET A  85
TYR A  76
THR A 209
CYH A 251
 None
 1.06A 1uw6P-3hdoA:
undetectable
1uw6T-3hdoA:
undetectable		 1uw6P-3hdoA:
19.38
1uw6T-3hdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 PRO A 112
LEU A 133
GLY A 135
LEU A 160
 None
 0.81A 1ya4A-3hdoA:
undetectable		 1ya4A-3hdoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 7 PRO A 112
LEU A 133
GLY A 135
LEU A 160
 None
 0.76A 1ya4B-3hdoA:
undetectable		 1ya4B-3hdoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 12 MET A 219
GLY A 222
SER A 211
ALA A 224
ALA A  86
 None
 1.39A 2avdA-3hdoA:
4.0		 2avdA-3hdoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 6 HIS A 319
ASP A 285
THR A 297
TYR A 284
 None
 1.21A 2eimN-3hdoA:
undetectable
2eimP-3hdoA:
undetectable		 2eimN-3hdoA:
21.57
2eimP-3hdoA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 12 LEU A 310
THR A 342
MET A 329
LEU A 279
ILE A 282
 None
 1.42A 2ydoA-3hdoA:
undetectable		 2ydoA-3hdoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 8 ARG A 280
PRO A 112
GLY A 161
PRO A 162
 None
 0.83A 3hcrA-3hdoA:
undetectable		 3hcrA-3hdoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 12 ARG A 127
GLY A 125
LEU A 120
GLU A 106
ALA A 101
 None
 0.97A 3kkzA-3hdoA:
3.6		 3kkzA-3hdoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 12 LEU A 182
ASP A 183
SER A 163
ILE A 169
SER A 289
 None
 1.24A 3ko0K-3hdoA:
undetectable
3ko0L-3hdoA:
undetectable
3ko0M-3hdoA:
undetectable
3ko0N-3hdoA:
undetectable		 3ko0K-3hdoA:
14.61
3ko0L-3hdoA:
14.61
3ko0M-3hdoA:
14.61
3ko0N-3hdoA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 10 SER A 289
SER A 163
ILE A 169
LEU A 182
ASP A 183
 None
 1.29A 3m0wC-3hdoA:
undetectable
3m0wD-3hdoA:
undetectable
3m0wE-3hdoA:
undetectable
3m0wF-3hdoA:
undetectable		 3m0wC-3hdoA:
14.33
3m0wD-3hdoA:
14.33
3m0wE-3hdoA:
14.33
3m0wF-3hdoA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_F_P77F203_1
(PROTEIN S100-A4)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 9 LEU A 182
ASP A 183
SER A 163
ILE A 169
SER A 289
 None
 1.27A 3m0wC-3hdoA:
undetectable
3m0wD-3hdoA:
undetectable
3m0wE-3hdoA:
undetectable
3m0wF-3hdoA:
undetectable		 3m0wC-3hdoA:
14.33
3m0wD-3hdoA:
14.33
3m0wE-3hdoA:
14.33
3m0wF-3hdoA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 10 LEU A 182
ASP A 183
SER A 163
ILE A 169
SER A 289
 None
 1.28A 3m0wA-3hdoA:
undetectable
3m0wB-3hdoA:
undetectable
3m0wI-3hdoA:
undetectable
3m0wJ-3hdoA:
undetectable		 3m0wA-3hdoA:
14.33
3m0wB-3hdoA:
14.33
3m0wI-3hdoA:
14.33
3m0wJ-3hdoA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 6 PHE A 131
LEU A 153
ASN A 157
ARG A 129
 None
 1.37A 4yv5B-3hdoA:
undetectable		 4yv5B-3hdoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 6 PHE A 131
LEU A 153
ASN A 157
ARG A 129
 None
 1.38A 4yv5A-3hdoA:
undetectable		 4yv5A-3hdoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		4 / 4 ILE A 282
ILE A 349
ARG A 305
TYR A 284
 None
 1.47A 4zzbC-3hdoA:
0.0		 4zzbC-3hdoA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Geobacter
metallireducens) 		5 / 12 LEU A 160
PHE A 320
PRO A 112
THR A 119
GLY A 118
 None
 1.04A 5xipA-3hdoA:
undetectable		 5xipA-3hdoA:
19.80