SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 489
ASN A 508
GLY A 488
VAL A 166
 None
 0.92A 1dbbH-3hdxA:
undetectable
1dbbL-3hdxA:
undetectable		 1dbbH-3hdxA:
17.26
1dbbL-3hdxA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A  60
PHE A 295
VAL A  55
ALA A  62
 None
 1.06A 1fo4B-3hdxA:
undetectable		 1fo4B-3hdxA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 144
TYR A  56
SER A 232
TYR A 208
TYR A 215
 None
EDO  A 609 (-4.0A)
EDO  A 608 ( 4.1A)
None
None
 1.34A 1maaA-3hdxA:
undetectable		 1maaA-3hdxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 470
ILE A 450
ALA A 405
ALA A 250
 None
 0.88A 1w0gA-3hdxA:
undetectable		 1w0gA-3hdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 161
VAL A 106
THR A  68
 None
 0.83A 2nnkA-3hdxA:
undetectable		 2nnkA-3hdxA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A 498
ARG A 111
ILE A 116
PHE A 178
 None
 1.17A 2q72A-3hdxA:
undetectable		 2q72A-3hdxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 225
TYR A  56
LEU A  52
GLN A 147
TYR A 143
 EDO  A 608 (-3.4A)
EDO  A 609 (-4.0A)
None
None
None
 1.05A 2vqyA-3hdxA:
undetectable		 2vqyA-3hdxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 TYR A 208
ALA A 146
ALA A 150
LEU A 293
VAL A 236
 None
None
None
EDO  A 608 (-4.1A)
None
 1.35A 2wuzA-3hdxA:
undetectable		 2wuzA-3hdxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 TYR A 208
ALA A 146
ALA A 150
LEU A 293
VAL A 236
 None
None
None
EDO  A 608 (-4.1A)
None
 1.38A 2wuzB-3hdxA:
undetectable		 2wuzB-3hdxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 128
GLU A 131
SER A 172
 None
 0.87A 2xctD-3hdxA:
undetectable		 2xctD-3hdxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 470
ARG A 454
ILE A 450
TYR A 247
 None
 1.14A 2yfbA-3hdxA:
undetectable		 2yfbA-3hdxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 470
ARG A 454
ILE A 450
TYR A 247
 None
 1.05A 2yfbB-3hdxA:
1.8		 2yfbB-3hdxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A 284
GLY A 225
ILE A 264
ASN A 265
SER A 232
 None
EDO  A 608 (-3.4A)
None
None
EDO  A 608 ( 4.1A)
 1.29A 3bwmA-3hdxA:
undetectable		 3bwmA-3hdxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 236
ALA A 233
LEU A 151
PHE A 154
LEU A  63
 None
 1.03A 3hj3C-3hdxA:
undetectable		 3hj3C-3hdxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 161
VAL A 106
THR A  68
 None
 0.81A 3k4vA-3hdxA:
undetectable		 3k4vA-3hdxA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 161
VAL A 106
THR A  68
 None
 0.74A 3ndtA-3hdxA:
undetectable		 3ndtA-3hdxA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 136
LEU A 141
PHE A 122
TRP A  42
 None
 1.25A 3nk2X-3hdxA:
undetectable		 3nk2X-3hdxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 232
LEU A 151
ALA A 146
ALA A 200
 EDO  A 608 ( 4.1A)
None
None
None
 1.00A 3ns1L-3hdxA:
undetectable		 3ns1L-3hdxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 161
VAL A 106
THR A  68
 None
 0.82A 3pwrA-3hdxA:
undetectable		 3pwrA-3hdxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ARG A 454
ILE A 450
PHE A 451
ALA A 417
LEU A 474
 None
 1.22A 3s79A-3hdxA:
undetectable		 3s79A-3hdxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 161
VAL A 106
THR A  68
 None
 0.83A 3tl9A-3hdxA:
undetectable		 3tl9A-3hdxA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 158
THR A 395
TYR A 466
LEU A 403
 None
 0.96A 3wipG-3hdxA:
undetectable
3wipH-3hdxA:
undetectable		 3wipG-3hdxA:
18.43
3wipH-3hdxA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 403
TYR A 158
THR A 395
TYR A 466
 None
 0.98A 3wipF-3hdxA:
undetectable
3wipJ-3hdxA:
undetectable		 3wipF-3hdxA:
18.43
3wipJ-3hdxA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 399
LEU A 403
GLU A 406
ARG A 454
ASP A 467
 None
 1.46A 4b9zA-3hdxA:
undetectable		 4b9zA-3hdxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 466
ARG A 470
HIS A 239
 None
 1.22A 4fubA-3hdxA:
undetectable		 4fubA-3hdxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 VAL A 148
TYR A 143
VAL A 130
THR A 129
 None
 0.78A 4ma7A-3hdxA:
undetectable		 4ma7A-3hdxA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 471
ASP A 467
ARG A 454
 EDO  A 604 (-4.4A)
None
None
 0.60A 4wq4B-3hdxA:
undetectable		 4wq4B-3hdxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 225
SER A 283
ILE A 264
ASN A 265
SER A 232
 EDO  A 608 (-3.4A)
None
None
None
EDO  A 608 ( 4.1A)
 1.19A 4xueB-3hdxA:
undetectable		 4xueB-3hdxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 345
ARG A 428
ILE A 424
GLU A 398
 None
 0.89A 4zzcB-3hdxA:
undetectable
4zzcC-3hdxA:
undetectable		 4zzcB-3hdxA:
20.95
4zzcC-3hdxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 345
ARG A 428
ILE A 424
GLU A 398
 None
 0.89A 4zzcC-3hdxA:
1.1
4zzcD-3hdxA:
1.1		 4zzcC-3hdxA:
20.95
4zzcD-3hdxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE401_0
(PROTON-GATED ION
CHANNEL)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 428
ILE A 424
GLU A 398
ARG A 345
 None
 0.91A 4zzcA-3hdxA:
1.1
4zzcE-3hdxA:
1.0		 4zzcA-3hdxA:
20.95
4zzcE-3hdxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ARG A 454
ILE A 450
PHE A 451
ALA A 417
LEU A 474
 None
 1.23A 5jkvA-3hdxA:
undetectable		 5jkvA-3hdxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 208
TYR A 215
TRP A 223
TYR A  56
 None
None
EDO  A 601 (-3.9A)
EDO  A 609 (-4.0A)
 1.29A 5ov9A-3hdxA:
undetectable		 5ov9A-3hdxA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 208
TYR A 215
TRP A 223
TYR A  56
 None
None
EDO  A 601 (-3.9A)
EDO  A 609 (-4.0A)
 1.27A 5ov9B-3hdxA:
undetectable		 5ov9B-3hdxA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  65
ASN A  66
ASP A 101
 None
 0.77A 5vopA-3hdxA:
undetectable		 5vopA-3hdxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  65
ASN A  66
ASP A 101
 None
 0.82A 5vopB-3hdxA:
undetectable		 5vopB-3hdxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  76
THR A  68
VAL A 106
TRP A 163
 None
 1.22A 5ysiA-3hdxA:
undetectable		 5ysiA-3hdxA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 3hdx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 GLN A 244
ASN A 246
LEU A 190
SER A 191
 None
 1.26A 6ekuA-3hdxA:
undetectable		 6ekuA-3hdxA:
21.67