SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3heb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 VAL A  84
VAL A  11
ALA A  45
LEU A  49
 None
 0.83A 1pthA-3hebA:
undetectable		 1pthA-3hebA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 VAL A  84
VAL A  11
ALA A  45
LEU A  49
 None
 0.83A 1pthB-3hebA:
undetectable		 1pthB-3hebA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 8 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.66A 1rtsA-3hebA:
undetectable		 1rtsA-3hebA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.65A 2tsrA-3hebA:
undetectable		 2tsrA-3hebA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 5 ASN A 116
ALA A 115
GLY A 114
TYR A 111
 None
 1.18A 3bcrA-3hebA:
5.0		 3bcrA-3hebA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 LEU A  49
VAL A  84
VAL A  11
LEU A 113
 None
 0.87A 3rgfA-3hebA:
undetectable		 3rgfA-3hebA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.68A 4iqqA-3hebA:
undetectable		 4iqqA-3hebA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.65A 4iqqB-3hebA:
undetectable		 4iqqB-3hebA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.64A 4iqqC-3hebA:
undetectable		 4iqqC-3hebA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 8 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.70A 4iqqD-3hebA:
undetectable		 4iqqD-3hebA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 4 THR A  90
GLY A  51
ASP A  53
SER A  59
 None
 1.36A 4rfqA-3hebA:
undetectable		 4rfqA-3hebA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		3 / 3 GLY A  18
ASP A  16
ASN A  71
 None
 0.59A 5jglA-3hebA:
3.1		 5jglA-3hebA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.64A 5nooA-3hebA:
undetectable		 5nooA-3hebA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 7 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.70A 5x5qC-3hebA:
undetectable		 5x5qC-3hebA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 8 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.67A 5x5qD-3hebA:
undetectable		 5x5qD-3hebA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		4 / 8 ILE A  10
LEU A 135
GLY A 136
PHE A 139
 None
 0.66A 5x5qF-3hebA:
undetectable		 5x5qF-3hebA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		3 / 3 TYR A 125
ASN A  26
LEU A  22
 None
 0.74A 6b58A-3hebA:
1.6		 6b58A-3hebA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)
(Rhodospirillum
rubrum) 		5 / 12 VAL A  95
VAL A  66
GLY A  56
THR A  43
GLY A  42
 None
 1.14A 6brdC-3hebA:
undetectable		 6brdC-3hebA:
20.14