SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hee'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  61
ARG A  60
GLY A  46
ALA A  75
ILE A  81
 None
 0.95A 1bx4A-3heeA:
undetectable		 1bx4A-3heeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A  41
GLY A  70
ILE A  73
ALA A  50
 None
R5P  A 651 (-3.3A)
None
None
 0.65A 1n49A-3heeA:
undetectable		 1n49A-3heeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  33
ILE A  18
ILE A  62
GLY A   4
ILE A  30
 None
 0.89A 1sguB-3heeA:
undetectable		 1sguB-3heeA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  33
ILE A  18
ILE A  62
GLY A   4
ILE A  30
 None
 1.05A 1sh9B-3heeA:
undetectable		 1sh9B-3heeA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 LEU A 124
ILE A  18
GLY A  61
CYH A  58
 None
 0.79A 1sv9A-3heeA:
undetectable		 1sv9A-3heeA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A 117
VAL A 120
VAL A  29
ILE A   5
 None
 0.91A 1t87B-3heeA:
undetectable		 1t87B-3heeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LEU A  14
LEU A 106
LEU A 115
LEU A 117
 None
 1.00A 2ab2A-3heeA:
undetectable		 2ab2A-3heeA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU A  14
LEU A 106
LEU A 115
LEU A 117
 None
 1.02A 2ab2B-3heeA:
undetectable		 2ab2B-3heeA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A   8
GLY A  66
TYR A  42
 R5P  A 651 (-2.7A)
R5P  A 651 (-3.5A)
R5P  A 651 (-3.9A)
 0.78A 3w9tC-3heeA:
undetectable		 3w9tC-3heeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A   8
GLY A  66
TYR A  42
 R5P  A 651 (-2.7A)
R5P  A 651 (-3.5A)
R5P  A 651 (-3.9A)
 0.78A 3w9tG-3heeA:
undetectable		 3w9tG-3heeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 THR A  34
GLY A   6
ARG A 109
ILE A  71
 None
None
R5P  A 651 (-3.3A)
None
 1.11A 4acaC-3heeA:
2.5		 4acaC-3heeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 7 ALA A  52
GLY A   6
ILE A  62
GLY A  61
ILE A 103
 None
 0.79A 4eatA-3heeA:
2.7		 4eatA-3heeA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ALA A  52
GLY A   6
ILE A  62
GLY A  61
ILE A 103
 None
 0.77A 4eatB-3heeA:
undetectable		 4eatB-3heeA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A 103
LYS A  15
ILE A   5
GLY A 107
 None
 0.98A 4hdlA-3heeA:
undetectable		 4hdlA-3heeA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLY A  33
ILE A  18
ILE A  62
GLY A   4
ILE A  30
 None
 0.92A 4q1xA-3heeA:
undetectable		 4q1xA-3heeA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  61
ARG A  60
GLY A  46
ALA A  75
ILE A  81
 None
 0.92A 5kb6B-3heeA:
undetectable		 5kb6B-3heeA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		6 / 12 GLY A 107
GLY A  66
LEU A  69
VAL A  85
ALA A 105
LEU A 106
 None
R5P  A 651 (-3.5A)
None
None
None
None
 1.30A 5kpcA-3heeA:
undetectable		 5kpcA-3heeA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 117
ALA A 116
LEU A  14
ILE A   3
LEU A 104
 None
 1.05A 5toaA-3heeA:
undetectable		 5toaA-3heeA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  68
VAL A 120
VAL A 111
ALA A 116
LEU A 104
 None
 1.14A 6czmA-3heeA:
2.5
6czmC-3heeA:
3.4		 6czmA-3heeA:
18.86
6czmC-3heeA:
18.86