SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hf1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		3 / 3 TRP A 171
VAL A 256
TRP A 175
 None
 1.20A 1c4dC-3hf1A:
undetectable
1c4dD-3hf1A:
undetectable		 1c4dC-3hf1A:
2.85
1c4dD-3hf1A:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		3 / 3 GLU A 194
HIS A 231
ASP A 100
 FE  A 401 (-2.5A)
FE  A 401 (-3.2A)
None
 0.73A 1i9gA-3hf1A:
undetectable		 1i9gA-3hf1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		3 / 3 GLU A 228
HIS A 231
ASP A 100
 FE  A 401 (-2.9A)
FE  A 401 (-3.2A)
None
 0.79A 1i9gA-3hf1A:
undetectable		 1i9gA-3hf1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		6 / 11 GLU A 131
HIS A 134
GLU A 194
PHE A 202
ILE A 224
GLU A 228
 FE  A 401 (-2.5A)
None
FE  A 401 (-2.5A)
None
None
FE  A 401 (-2.9A)
 0.74A 1rnrA-3hf1A:
27.7		 1rnrA-3hf1A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		5 / 11 GLU A 228
HIS A 134
GLU A 194
ILE A 130
GLU A 131
 FE  A 401 (-2.9A)
None
FE  A 401 (-2.5A)
None
FE  A 401 (-2.5A)
 1.38A 1rnrA-3hf1A:
27.7		 1rnrA-3hf1A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		5 / 11 HIS A 134
SER A 201
PHE A 202
ILE A 224
GLU A 228
 None
None
None
None
FE  A 401 (-2.9A)
 0.78A 1rnrA-3hf1A:
27.7		 1rnrA-3hf1A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		6 / 12 GLU A 131
HIS A 134
GLU A 194
PHE A 202
ILE A 224
GLU A 228
 FE  A 401 (-2.5A)
None
FE  A 401 (-2.5A)
None
None
FE  A 401 (-2.9A)
 0.72A 1rnrB-3hf1A:
27.7		 1rnrB-3hf1A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		6 / 12 GLU A 131
HIS A 134
TYR A 138
GLU A 194
ILE A 224
GLU A 228
 FE  A 401 (-2.5A)
None
None
FE  A 401 (-2.5A)
None
FE  A 401 (-2.9A)
 0.77A 1rnrB-3hf1A:
27.7		 1rnrB-3hf1A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 8 SER A 220
ASN A 221
ILE A 224
TYR A 145
 None
 1.08A 2v57A-3hf1A:
undetectable		 2v57A-3hf1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 8 SER A 220
ASN A 221
ILE A 224
TYR A 145
 None
 1.08A 2v57C-3hf1A:
undetectable		 2v57C-3hf1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 6 VAL A  69
LEU A  81
ILE A  92
LEU A  71
 None
 0.92A 3kk6A-3hf1A:
0.3		 3kk6A-3hf1A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 8 PHE A 239
VAL A 251
ILE A 254
ILE A 176
 None
 0.62A 3uqbA-3hf1A:
undetectable		 3uqbA-3hf1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		5 / 12 PHE A 206
SER A 220
HIS A 134
TYR A 138
LEU A  93
 None
 1.28A 3vn2A-3hf1A:
undetectable		 3vn2A-3hf1A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 8 VAL A 115
PRO A  33
GLN A  48
ILE A  52
 None
 0.97A 4iilA-3hf1A:
undetectable		 4iilA-3hf1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		3 / 3 GLU A 194
HIS A 231
ASP A 100
 FE  A 401 (-2.5A)
FE  A 401 (-3.2A)
None
 0.84A 5c0oG-3hf1A:
undetectable		 5c0oG-3hf1A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		3 / 3 GLU A 228
HIS A 231
ASP A 100
 FE  A 401 (-2.9A)
FE  A 401 (-3.2A)
None
 0.82A 5c0oG-3hf1A:
undetectable		 5c0oG-3hf1A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 6 SER A 201
ALA A 204
MET A 282
LEU A 270
 None
 1.10A 5dzkB-3hf1A:
undetectable
5dzkP-3hf1A:
undetectable		 5dzkB-3hf1A:
20.51
5dzkP-3hf1A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 5 SER A 201
ALA A 204
MET A 282
LEU A 270
 None
 1.11A 5dzkc-3hf1A:
undetectable
5dzkq-3hf1A:
undetectable		 5dzkc-3hf1A:
20.51
5dzkq-3hf1A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 5 SER A 201
ALA A 204
MET A 282
LEU A 270
 None
 1.21A 5dzkf-3hf1A:
undetectable
5dzkt-3hf1A:
undetectable		 5dzkf-3hf1A:
20.51
5dzkt-3hf1A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 6 SER A 201
ALA A 204
MET A 282
LEU A 270
 None
 1.14A 5dzkg-3hf1A:
undetectable
5dzku-3hf1A:
undetectable		 5dzkg-3hf1A:
20.51
5dzku-3hf1A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens) 		4 / 5 ILE A 224
SER A 220
ALA A  97
LYS A 168
 None
 0.95A 6dwnA-3hf1A:
undetectable		 6dwnA-3hf1A:
14.24