SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 7 LEU A 242
PHE A 241
LEU A 236
ALA A 119
 None
 0.87A 1j8uA-3hf8A:
42.3		 1j8uA-3hf8A:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 7 VAL A 232
LEU A 236
PHE A 241
LEU A 242
ALA A 309
 None
 0.30A 1j8uA-3hf8A:
42.3		 1j8uA-3hf8A:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		9 / 12 VAL A 232
LEU A 236
PHE A 241
LEU A 242
THR A 253
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 None
None
None
None
None
FE  A 400 ( 4.6A)
FE  A 400 (-3.2A)
None
FE  A 400 ( 1.9A)
 0.95A 1kw0A-3hf8A:
40.6		 1kw0A-3hf8A:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 12 TYR A 235
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 ML0  A 401 (-3.9A)
FE  A 400 ( 4.6A)
FE  A 400 (-3.2A)
None
FE  A 400 ( 1.9A)
 1.19A 1mmkA-3hf8A:
40.7		 1mmkA-3hf8A:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		8 / 12 VAL A 232
LEU A 236
PHE A 241
LEU A 242
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 None
None
None
None
FE  A 400 ( 4.6A)
FE  A 400 (-3.2A)
None
FE  A 400 ( 1.9A)
 0.88A 1mmkA-3hf8A:
40.7		 1mmkA-3hf8A:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		8 / 11 LEU A 236
PHE A 241
LEU A 242
THR A 253
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 None
None
None
None
FE  A 400 ( 4.6A)
FE  A 400 (-3.2A)
None
FE  A 400 ( 1.9A)
 0.82A 1mmtA-3hf8A:
40.7		 1mmtA-3hf8A:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		8 / 11 VAL A 232
LEU A 236
PHE A 241
LEU A 242
THR A 253
GLU A 273
HIS A 277
GLU A 317
 None
None
None
None
None
FE  A 400 ( 4.6A)
FE  A 400 (-3.2A)
FE  A 400 ( 1.9A)
 0.82A 1mmtA-3hf8A:
40.7		 1mmtA-3hf8A:
64.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 12 TYR A 206
VAL A 256
ASP A 269
SER A 336
TYR A 193
 None
None
None
ML0  A 401 (-2.6A)
None
 1.45A 1xvaA-3hf8A:
undetectable		 1xvaA-3hf8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 SER A 339
THR A 265
SER A 337
PRO A 262
 None
ML0  A 401 (-4.4A)
ML0  A 401 (-4.0A)
None
 1.38A 2hdnB-3hf8A:
undetectable
2hdnC-3hf8A:
undetectable
2hdnD-3hf8A:
undetectable		 2hdnB-3hf8A:
20.80
2hdnC-3hf8A:
8.80
2hdnD-3hf8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 12 VAL A 316
THR A 225
ALA A 287
ILE A 229
CYH A 252
 None
 1.45A 2qm9B-3hf8A:
undetectable		 2qm9B-3hf8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.30A 2y69C-3hf8A:
undetectable
2y69J-3hf8A:
undetectable		 2y69C-3hf8A:
21.23
2y69J-3hf8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.31A 2y69P-3hf8A:
undetectable
2y69W-3hf8A:
undetectable		 2y69P-3hf8A:
21.23
2y69W-3hf8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 GLN A 288
PHE A 289
LEU A 281
PHE A 250
 None
 1.35A 3ablC-3hf8A:
undetectable
3ablJ-3hf8A:
undetectable		 3ablC-3hf8A:
21.23
3ablJ-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.30A 3abmC-3hf8A:
undetectable
3abmJ-3hf8A:
undetectable		 3abmC-3hf8A:
21.23
3abmJ-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.26A 3abmP-3hf8A:
undetectable
3abmW-3hf8A:
undetectable		 3abmP-3hf8A:
21.23
3abmW-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.32A 3ag3C-3hf8A:
undetectable
3ag3J-3hf8A:
undetectable		 3ag3C-3hf8A:
21.23
3ag3J-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 SER A 376
LEU A 280
GLY A 331
CYH A 190
 None
 1.08A 3aiaA-3hf8A:
undetectable
3aiaB-3hf8A:
undetectable		 3aiaA-3hf8A:
20.66
3aiaB-3hf8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 8 HIS A 272
PRO A 268
SER A 290
PHE A 250
 FE  A 400 ( 3.3A)
ML0  A 401 (-3.6A)
None
None
 1.23A 4kttC-3hf8A:
undetectable		 4kttC-3hf8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 11 GLY A 331
GLY A 319
LEU A 334
GLU A 340
HIS A 272
 None
None
None
None
FE  A 400 ( 3.3A)
 0.96A 4l8fB-3hf8A:
undetectable		 4l8fB-3hf8A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 11 GLY A 331
GLY A 319
LEU A 334
GLU A 340
HIS A 272
 None
None
None
None
FE  A 400 ( 3.3A)
 1.01A 4l8fD-3hf8A:
undetectable		 4l8fD-3hf8A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 7 HIS A 272
PRO A 268
SER A 290
PHE A 250
 FE  A 400 ( 3.3A)
ML0  A 401 (-3.6A)
None
None
 1.25A 4ndnC-3hf8A:
undetectable		 4ndnC-3hf8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A 298
LEU A 295
GLY A 294
GLN A 291
VAL A 249
 None
 1.24A 4oktA-3hf8A:
undetectable		 4oktA-3hf8A:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 6 PHE A 241
HIS A 272
HIS A 277
TYR A 312
GLU A 317
 None
FE  A 400 ( 3.3A)
FE  A 400 (-3.2A)
None
FE  A 400 ( 1.9A)
 0.54A 4pahA-3hf8A:
41.9		 4pahA-3hf8A:
66.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 12 TYR A 235
HIS A 272
GLU A 273
HIS A 277
GLU A 317
 ML0  A 401 (-3.9A)
FE  A 400 ( 3.3A)
FE  A 400 ( 4.6A)
FE  A 400 (-3.2A)
FE  A 400 ( 1.9A)
 1.27A 4r7lA-3hf8A:
undetectable		 4r7lA-3hf8A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 LEU A 115
LEU A 242
PHE A 241
VAL A 232
 None
 1.01A 4udaA-3hf8A:
undetectable		 4udaA-3hf8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		3 / 3 LEU A 214
VAL A 256
ASP A 269
 None
 0.69A 4y8wC-3hf8A:
undetectable		 4y8wC-3hf8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		3 / 5 GLY A 276
GLY A 333
GLU A 317
 None
ML0  A 401 (-3.9A)
FE  A 400 ( 1.9A)
 0.46A 4z2eA-3hf8A:
undetectable
4z2eD-3hf8A:
undetectable		 4z2eA-3hf8A:
20.39
4z2eD-3hf8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 7 HIS A 272
PRO A 268
SER A 290
PHE A 250
 FE  A 400 ( 3.3A)
ML0  A 401 (-3.6A)
None
None
 1.31A 5a1iA-3hf8A:
undetectable		 5a1iA-3hf8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 SER A 285
GLU A 380
GLY A 276
GLY A 331
 None
 0.85A 5cdpA-3hf8A:
undetectable
5cdpB-3hf8A:
undetectable		 5cdpA-3hf8A:
21.54
5cdpB-3hf8A:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 4 HIS A 272
HIS A 277
TYR A 312
GLU A 317
 FE  A 400 ( 3.3A)
FE  A 400 (-3.2A)
None
FE  A 400 ( 1.9A)
 0.45A 5pahA-3hf8A:
41.7		 5pahA-3hf8A:
66.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 ILE A 358
ILE A 293
PHE A 389
PHE A 241
 None
 0.96A 5vkqA-3hf8A:
undetectable
5vkqB-3hf8A:
undetectable		 5vkqA-3hf8A:
9.36
5vkqB-3hf8A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 ILE A 358
ILE A 293
PHE A 389
PHE A 241
 None
 0.95A 5vkqB-3hf8A:
undetectable
5vkqC-3hf8A:
undetectable		 5vkqB-3hf8A:
9.36
5vkqC-3hf8A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 ILE A 358
ILE A 293
PHE A 389
PHE A 241
 None
 0.94A 5vkqC-3hf8A:
undetectable
5vkqD-3hf8A:
undetectable		 5vkqC-3hf8A:
9.36
5vkqD-3hf8A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 PHE A 241
ILE A 358
ILE A 293
PHE A 389
 None
 0.93A 5vkqA-3hf8A:
undetectable
5vkqD-3hf8A:
undetectable		 5vkqA-3hf8A:
9.36
5vkqD-3hf8A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.32A 5wauC-3hf8A:
undetectable
5wauJ-3hf8A:
undetectable		 5wauC-3hf8A:
21.23
5wauJ-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.30A 5wauc-3hf8A:
undetectable
5wauj-3hf8A:
undetectable		 5wauc-3hf8A:
21.23
5wauj-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.26A 5xdqC-3hf8A:
undetectable
5xdqJ-3hf8A:
undetectable		 5xdqC-3hf8A:
21.23
5xdqJ-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 5 PHE A 289
PHE A 286
LEU A 281
PHE A 250
 None
 1.28A 5xdqP-3hf8A:
undetectable
5xdqW-3hf8A:
undetectable		 5xdqP-3hf8A:
21.23
5xdqW-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 PHE A 227
VAL A 316
LEU A 242
LEU A 245
 None
 0.98A 6e43A-3hf8A:
undetectable		 6e43A-3hf8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 PHE A 227
VAL A 316
LEU A 242
LEU A 245
 None
 1.03A 6e43B-3hf8A:
undetectable		 6e43B-3hf8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 PHE A 227
VAL A 316
LEU A 242
LEU A 245
 None
 0.95A 6e43C-3hf8A:
undetectable		 6e43C-3hf8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 7 HIS A 272
PRO A 268
SER A 290
PHE A 250
 FE  A 400 ( 3.3A)
ML0  A 401 (-3.6A)
None
None
 1.30A 6g6rA-3hf8A:
undetectable		 6g6rA-3hf8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		4 / 6 GLN A 288
PHE A 289
LEU A 281
PHE A 250
 None
 1.28A 6nmpC-3hf8A:
undetectable
6nmpJ-3hf8A:
undetectable		 6nmpC-3hf8A:
21.23
6nmpJ-3hf8A:
12.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens) 		5 / 6 PRO A 268
HIS A 272
HIS A 277
TYR A 312
GLU A 317
 ML0  A 401 (-3.6A)
FE  A 400 ( 3.3A)
FE  A 400 (-3.2A)
None
FE  A 400 ( 1.9A)
 0.65A 6pahA-3hf8A:
41.7		 6pahA-3hf8A:
66.21