SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hf9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  32
VAL A 210
LEU A 230
TYR A  35
LEU A 181
 None
 1.15A 1rlbF-3hf9A:
undetectable		 1rlbF-3hf9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ILE A  24
GLY A 145
ALA A 104
LEU A  74
 None
 0.95A 3hs6B-3hf9A:
undetectable		 3hs6B-3hf9A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 103
VAL A  60
ALA A 125
GLY A  78
ASP A  58
 None
 1.21A 4mm8A-3hf9A:
undetectable		 4mm8A-3hf9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA
(Mycobacterium
tuberculosis) 		5 / 11 TYR A 103
VAL A  60
ALA A 125
GLY A  78
ASP A  58
 None
 1.15A 4mm9A-3hf9A:
undetectable		 4mm9A-3hf9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 182
LEU A 181
ILE A 225
SER A 228
ALA A 232
 None
 1.36A 4z69A-3hf9A:
undetectable		 4z69A-3hf9A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 145
GLY A 108
LEU A 107
LEU A  74
TYR A 103
 None
 1.37A 5hwkA-3hf9A:
undetectable		 5hwkA-3hf9A:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 145
GLY A 108
LEU A 107
LEU A  74
TYR A 103
 None
 1.37A 5hwkB-3hf9A:
undetectable		 5hwkB-3hf9A:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3hf9 PROTEASOME (ALPHA
SUBUNIT) PRCA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  31
VAL A 212
ALA A 187
LEU A 233
LEU A 230
 None
 1.11A 5tudA-3hf9A:
undetectable		 5tudA-3hf9A:
18.16