SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3hfs ANTHOCYANIDIN
REDUCTASE
(Vitis
vinifera) 		4 / 7 GLU A 311
THR A 192
VAL A 193
ALA A 259
 None
 1.05A 1fo4B-3hfsA:
0.8		 1fo4B-3hfsA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3hfs ANTHOCYANIDIN
REDUCTASE
(Vitis
vinifera) 		5 / 12 VAL A 113
HIS A  86
ALA A  76
PHE A  64
VAL A  15
 None
 1.38A 2g72A-3hfsA:
5.3		 2g72A-3hfsA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3hfs ANTHOCYANIDIN
REDUCTASE
(Vitis
vinifera) 		4 / 8 MET A 198
PRO A 208
SER A 209
GLY A  19
 None
None
None
CL  A 339 ( 4.3A)
 1.09A 2qd5B-3hfsA:
2.5		 2qd5B-3hfsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3hfs ANTHOCYANIDIN
REDUCTASE
(Vitis
vinifera) 		5 / 12 GLY A  16
GLY A  17
GLY A  19
ALA A  66
VAL A 113
 None
None
CL  A 339 ( 4.3A)
None
None
 0.98A 4htfA-3hfsA:
6.2		 4htfA-3hfsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3hfs ANTHOCYANIDIN
REDUCTASE
(Vitis
vinifera) 		4 / 8 TYR A 317
LEU A  28
LEU A  24
THR A 204
 None
 1.16A 5hs6A-3hfsA:
14.0		 5hs6A-3hfsA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3hfs ANTHOCYANIDIN
REDUCTASE
(Vitis
vinifera) 		4 / 6 PRO A 208
GLY A 212
LEU A 197
VAL A  91
 None
None
None
CL  A 339 ( 4.5A)
 0.98A 5x80A-3hfsA:
undetectable
5x80B-3hfsA:
undetectable		 5x80A-3hfsA:
20.92
5x80B-3hfsA:
20.92