SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 203
TRP A 153
TRP A 176
 None
 1.40A 1c4dA-3hftA:
undetectable
1c4dB-3hftA:
undetectable		 1c4dA-3hftA:
9.45
1c4dB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		4 / 8 LEU A 252
LEU A 248
LEU A 183
THR A 215
 None
 0.92A 1dvtA-3hftA:
undetectable
1dvtB-3hftA:
undetectable		 1dvtA-3hftA:
17.87
1dvtB-3hftA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		5 / 12 ASP A 146
HIS A  91
ASP A  43
ASP A 205
TYR A 174
 None
ZN  A 257 ( 3.4A)
EDO  A 261 (-3.4A)
EDO  A 261 (-4.3A)
None
 1.29A 1t69A-3hftA:
undetectable		 1t69A-3hftA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		4 / 5 PHE A  94
PHE A  69
PHE A 138
ILE A  80
 None
 1.36A 2v0mD-3hftA:
undetectable		 2v0mD-3hftA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 151
TRP A 176
TRP A 153
 None
 1.11A 2xdcA-3hftA:
undetectable
2xdcB-3hftA:
undetectable		 2xdcA-3hftA:
9.45
2xdcB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 203
TRP A 153
TRP A 176
 None
 1.38A 2xdcA-3hftA:
undetectable
2xdcB-3hftA:
undetectable		 2xdcA-3hftA:
9.45
2xdcB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 TRP A 153
VAL A 151
TRP A 176
 None
 1.10A 2xdcA-3hftA:
undetectable
2xdcB-3hftA:
undetectable		 2xdcA-3hftA:
9.45
2xdcB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 TRP A 176
VAL A 203
TRP A 153
 None
 1.37A 2xdcA-3hftA:
undetectable
2xdcB-3hftA:
undetectable		 2xdcA-3hftA:
9.45
2xdcB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 151
TRP A 176
TRP A 153
 None
 1.08A 2xdcC-3hftA:
undetectable
2xdcD-3hftA:
undetectable		 2xdcC-3hftA:
9.45
2xdcD-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 151
TRP A 176
TRP A 153
 None
 1.11A 2y5mA-3hftA:
undetectable
2y5mB-3hftA:
undetectable		 2y5mA-3hftA:
9.45
2y5mB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 203
TRP A 153
TRP A 176
 None
 1.38A 2y5mA-3hftA:
undetectable
2y5mB-3hftA:
undetectable		 2y5mA-3hftA:
9.45
2y5mB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 151
TRP A 176
TRP A 153
 None
 1.10A 2y6nA-3hftA:
undetectable
2y6nB-3hftA:
undetectable		 2y6nA-3hftA:
9.45
2y6nB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 203
TRP A 153
TRP A 176
 None
 1.37A 2y6nA-3hftA:
undetectable
2y6nB-3hftA:
undetectable		 2y6nA-3hftA:
9.45
2y6nB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 TRP A 153
VAL A 151
TRP A 176
 None
 1.08A 2y6nA-3hftA:
undetectable
2y6nB-3hftA:
undetectable		 2y6nA-3hftA:
9.45
2y6nB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 TRP A 176
VAL A 203
TRP A 153
 None
 1.36A 2y6nA-3hftA:
undetectable
2y6nB-3hftA:
undetectable		 2y6nA-3hftA:
9.45
2y6nB-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		4 / 5 ASP A 146
ARG A 171
TRP A 162
ILE A 149
 None
 1.29A 3sanA-3hftA:
undetectable		 3sanA-3hftA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		4 / 5 ASP A 146
ARG A 171
TRP A 162
ILE A 149
 None
 1.28A 3sanB-3hftA:
undetectable		 3sanB-3hftA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 151
TRP A 176
TRP A 153
 None
 1.05A 3zq8A-3hftA:
undetectable
3zq8B-3hftA:
undetectable		 3zq8A-3hftA:
9.45
3zq8B-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 VAL A 203
TRP A 153
TRP A 176
 None
 1.42A 3zq8A-3hftA:
undetectable
3zq8B-3hftA:
undetectable		 3zq8A-3hftA:
9.45
3zq8B-3hftA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		4 / 5 ASP A 146
ARG A 171
TRP A 162
ILE A 149
 None
 1.31A 4mwrA-3hftA:
undetectable		 4mwrA-3hftA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 ARG A 171
TRP A 162
ILE A 149
 None
 0.92A 4mwxA-3hftA:
undetectable		 4mwxA-3hftA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		4 / 4 LEU A 110
LEU A 143
GLY A 139
GLU A 140
 None
 1.17A 5hhjA-3hftA:
undetectable		 5hhjA-3hftA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		5 / 6 ASP A  43
ASP A  45
HIS A  91
HIS A 126
HIS A 207
 EDO  A 261 (-3.4A)
ZN  A 257 (-2.1A)
ZN  A 257 ( 3.4A)
ZN  A 257 ( 3.4A)
EDO  A 261 (-3.8A)
 0.76A 5ncdA-3hftA:
10.7
5ncdD-3hftA:
10.4		 5ncdA-3hftA:
24.41
5ncdD-3hftA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		5 / 6 ASP A  43
ASP A  45
HIS A  91
HIS A 126
HIS A 207
 EDO  A 261 (-3.4A)
ZN  A 257 (-2.1A)
ZN  A 257 ( 3.4A)
ZN  A 257 ( 3.4A)
EDO  A 261 (-3.8A)
 0.70A 5ncdB-3hftA:
10.8
5ncdC-3hftA:
10.8		 5ncdB-3hftA:
24.41
5ncdC-3hftA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		4 / 4 ASP A  43
HIS A  91
HIS A 126
HIS A 207
 EDO  A 261 (-3.4A)
ZN  A 257 ( 3.4A)
ZN  A 257 ( 3.4A)
EDO  A 261 (-3.8A)
 0.75A 5ncdD-3hftA:
10.3		 5ncdD-3hftA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		5 / 8 ASP A  43
ASP A  45
HIS A  91
HIS A 126
HIS A 207
 EDO  A 261 (-3.4A)
ZN  A 257 (-2.1A)
ZN  A 257 ( 3.4A)
ZN  A 257 ( 3.4A)
EDO  A 261 (-3.8A)
 0.72A 5nekB-3hftA:
10.9		 5nekB-3hftA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		5 / 8 ASP A  43
ASP A  45
HIS A  91
HIS A 126
HIS A 207
 EDO  A 261 (-3.4A)
ZN  A 257 (-2.1A)
ZN  A 257 ( 3.4A)
ZN  A 257 ( 3.4A)
EDO  A 261 (-3.8A)
 0.71A 5nekD-3hftA:
10.6		 5nekD-3hftA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		5 / 6 ASP A  43
ASP A  45
HIS A  91
HIS A 126
HIS A 207
 EDO  A 261 (-3.4A)
ZN  A 257 (-2.1A)
ZN  A 257 ( 3.4A)
ZN  A 257 ( 3.4A)
EDO  A 261 (-3.8A)
 0.76A 5nelA-3hftA:
10.8
5nelD-3hftA:
10.2		 5nelA-3hftA:
24.41
5nelD-3hftA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		4 / 6 ASP A  43
HIS A  91
HIS A 126
HIS A 207
 EDO  A 261 (-3.4A)
ZN  A 257 ( 3.4A)
ZN  A 257 ( 3.4A)
EDO  A 261 (-3.8A)
 0.74A 5nelB-3hftA:
10.7
5nelC-3hftA:
10.7		 5nelB-3hftA:
24.41
5nelC-3hftA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 HIS A 207
ASP A  45
HIS A  91
 EDO  A 261 (-3.8A)
ZN  A 257 (-2.1A)
ZN  A 257 ( 3.4A)
 0.74A 5oexB-3hftA:
undetectable		 5oexB-3hftA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 HIS A 207
ASP A  45
HIS A  91
 EDO  A 261 (-3.8A)
ZN  A 257 (-2.1A)
ZN  A 257 ( 3.4A)
 0.72A 5oexC-3hftA:
undetectable		 5oexC-3hftA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3hft WBMS, POLYSACCHARIDE
DEACETYLASE INVOLVED
IN O-ANTIGEN
BIOSYNTHESIS
(Bordetella
bronchiseptica) 		3 / 3 HIS A 207
ASP A  45
HIS A  91
 EDO  A 261 (-3.8A)
ZN  A 257 (-2.1A)
ZN  A 257 ( 3.4A)
 0.72A 5oexD-3hftA:
undetectable		 5oexD-3hftA:
20.04