SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 5 HIS A 164
GLU A 126
ALA A 131
SER A 158
 None
 1.32A 1errA-3hfwA:
undetectable
1errB-3hfwA:
1.6		 1errA-3hfwA:
21.35
1errB-3hfwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 8 ASP A  55
ASP A 304
GLY A  22
ASP A 302
 MG  A 361 (-2.9A)
MG  A 361 (-2.7A)
None
None
 0.80A 1m4iA-3hfwA:
undetectable		 1m4iA-3hfwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 5 LEU A 344
VAL A  48
LEU A  17
MET A 136
 None
 0.99A 2oiqA-3hfwA:
undetectable		 2oiqA-3hfwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 9 LEU A 292
LEU A  43
ALA A 307
LEU A  17
ALA A  13
 None
CL  A 360 (-4.7A)
None
None
None
 1.22A 2vcvD-3hfwA:
undetectable		 2vcvD-3hfwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 9 LEU A 292
LEU A  43
ALA A 307
LEU A  17
ALA A  13
 None
CL  A 360 (-4.7A)
None
None
None
 1.21A 2vcvE-3hfwA:
undetectable		 2vcvE-3hfwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 9 LEU A 292
LEU A  43
ALA A 307
LEU A  17
ALA A  13
 None
CL  A 360 (-4.7A)
None
None
None
 1.24A 2vcvH-3hfwA:
undetectable		 2vcvH-3hfwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 9 LEU A 292
LEU A  43
ALA A 307
LEU A  17
ALA A  13
 None
CL  A 360 (-4.7A)
None
None
None
 1.22A 2vcvI-3hfwA:
undetectable		 2vcvI-3hfwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2001_1
(SERUM ALBUMIN)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 12 PRO A 188
ILE A 277
HIS A 299
TYR A 230
ARG A 295
 None
 1.50A 2vufB-3hfwA:
0.7		 2vufB-3hfwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 6 THR A 259
GLY A 267
ARG A 234
ILE A 277
 None
 0.93A 4ac9C-3hfwA:
undetectable		 4ac9C-3hfwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 6 THR A 259
GLY A 267
ARG A 234
ILE A 277
 None
 0.98A 4acbC-3hfwA:
undetectable		 4acbC-3hfwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		3 / 3 PRO A 121
ASN A 106
HIS A 105
 None
 0.88A 4ma3H-3hfwA:
undetectable
4ma3L-3hfwA:
undetectable		 4ma3H-3hfwA:
18.75
4ma3L-3hfwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 9 ALA A 274
THR A 306
ALA A 278
GLY A 130
ALA A 132
 None
None
None
ADP  A 358 (-3.5A)
None
 1.11A 4qvnK-3hfwA:
undetectable
4qvnL-3hfwA:
undetectable		 4qvnK-3hfwA:
21.74
4qvnL-3hfwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 9 ALA A 274
THR A 306
ALA A 278
GLY A 130
ALA A 132
 None
None
None
ADP  A 358 (-3.5A)
None
 1.11A 4qvnY-3hfwA:
undetectable
4qvnZ-3hfwA:
undetectable		 4qvnY-3hfwA:
21.74
4qvnZ-3hfwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 9 VAL A 183
GLY A 139
SER A  11
ILE A 309
VAL A 316
 None
 0.94A 4r21B-3hfwA:
undetectable		 4r21B-3hfwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 7 TYR A 279
ILE A 309
GLY A 171
LEU A 195
 None
 0.91A 4ze3A-3hfwA:
undetectable		 4ze3A-3hfwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 12 TYR A  80
SER A 158
TRP A 118
LEU A 357
TYR A 205
 None
 1.42A 5dsgB-3hfwA:
0.0		 5dsgB-3hfwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 8 TYR A 279
ILE A 309
GLY A 171
LEU A 195
 None
 0.91A 5esjA-3hfwA:
undetectable		 5esjA-3hfwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 12 ALA A 135
GLY A 139
GLY A 159
SER A 158
LEU A  79
 None
 1.08A 5gwxA-3hfwA:
undetectable		 5gwxA-3hfwA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 5 ILE A 277
LEU A  17
GLY A  18
PHE A 297
 None
 0.87A 5kmdC-3hfwA:
undetectable
5kmdD-3hfwA:
undetectable		 5kmdC-3hfwA:
20.38
5kmdD-3hfwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 12 ALA A 135
GLY A 159
SER A 158
GLU A 157
LEU A  83
 None
 1.15A 5vlmF-3hfwA:
1.0		 5vlmF-3hfwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 12 MET A  59
ALA A 135
GLY A 159
SER A 158
GLU A 157
 None
 1.48A 5vlmF-3hfwA:
1.0		 5vlmF-3hfwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 12 MET A  59
GLY A 159
SER A 158
GLU A 157
LEU A  83
 None
 1.33A 5vlmF-3hfwA:
1.0		 5vlmF-3hfwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 10 PRO A 166
HIS A 165
ALA A 174
THR A 306
ALA A 132
 None
ADP  A 358 (-3.8A)
None
None
None
 1.19A 5vyhA-3hfwA:
undetectable		 5vyhA-3hfwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 10 TRP A 227
PRO A 166
HIS A 165
GLY A 192
ALA A 174
 None
None
ADP  A 358 (-3.8A)
None
None
 0.94A 5vyhA-3hfwA:
undetectable		 5vyhA-3hfwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 8 GLU A 228
HIS A 272
GLY A 192
LEU A 195
 None
 0.75A 5w3jB-3hfwA:
undetectable		 5w3jB-3hfwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 12 PHE A 142
LEU A 173
LEU A  76
LEU A  83
TYR A  80
 None
 1.26A 5y2oA-3hfwA:
undetectable		 5y2oA-3hfwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 5 TYR A   4
VAL A 323
MET A 136
GLY A 139
 None
 1.33A 6hd4A-3hfwA:
undetectable		 6hd4A-3hfwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		5 / 6 LEU A 344
TYR A   4
VAL A 323
MET A 136
GLY A 139
 None
 1.20A 6hd4B-3hfwA:
undetectable		 6hd4B-3hfwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE
(Homo
sapiens) 		4 / 5 LEU A 344
TYR A   4
MET A 136
GLY A 139
 None
 0.99A 6hd6A-3hfwA:
undetectable		 6hd6A-3hfwA:
12.61