SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 8 SER A 319
ARG A 274
ALA A 268
GLU A 323
 None
 0.94A 1dmiA-3hgqA:
undetectable
1dmiB-3hgqA:
undetectable		 1dmiA-3hgqA:
22.55
1dmiB-3hgqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 245
LEU A  79
GLY A  81
ARG A 138
 None
 1.45A 2j2pD-3hgqA:
undetectable
2j2pE-3hgqA:
undetectable		 2j2pD-3hgqA:
20.30
2j2pE-3hgqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 256
THR A 318
GLU A 261
 None
 0.72A 2zifB-3hgqA:
undetectable		 2zifB-3hgqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 247
PHE A 250
PHE A 251
 None
 0.81A 3cr5X-3hgqA:
undetectable		 3cr5X-3hgqA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 317
ASN A 242
LEU A 273
ASP A 275
 None
 1.20A 3lslA-3hgqA:
undetectable
3lslD-3hgqA:
undetectable		 3lslA-3hgqA:
21.85
3lslD-3hgqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  85
ILE A 244
LEU A 314
ILE A 241
THR A  86
 None
 1.10A 3qfxA-3hgqA:
undetectable		 3qfxA-3hgqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  85
ILE A 244
LEU A 314
ILE A 241
THR A  86
 None
 1.10A 3qfxB-3hgqA:
undetectable		 3qfxB-3hgqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 312
VAL A 239
TRP A  32
TYR A 288
ILE A 287
 None
 1.50A 3uf8A-3hgqA:
undetectable		 3uf8A-3hgqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 249
PRO A  34
VAL A 239
ASP A  30
 None
 1.10A 3ufnA-3hgqA:
undetectable
3ufnB-3hgqA:
undetectable		 3ufnA-3hgqA:
12.65
3ufnB-3hgqA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 8 MET A 201
LEU A 238
THR A 133
VAL A 178
 None
 0.91A 4ik6B-3hgqA:
undetectable		 4ik6B-3hgqA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 7 MET A 201
LEU A 238
THR A 133
VAL A 178
 None
 0.86A 4ik7A-3hgqA:
undetectable		 4ik7A-3hgqA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  85
ILE A 244
LEU A 314
ILE A 241
THR A  86
 None
 0.95A 4km0B-3hgqA:
undetectable		 4km0B-3hgqA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  85
ILE A 244
LEU A 314
ILE A 241
THR A  86
 None
 0.92A 4km2A-3hgqA:
undetectable		 4km2A-3hgqA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 240
LEU A 277
ILE A  48
LEU A  91
THR A  35
 None
 1.05A 4ky8A-3hgqA:
undetectable		 4ky8A-3hgqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 240
LEU A 277
ILE A  48
LEU A  91
THR A  35
 None
 1.06A 4ky8B-3hgqA:
undetectable		 4ky8B-3hgqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 240
LEU A 277
ILE A  48
LEU A  91
THR A  35
 None
 1.08A 4ky8C-3hgqA:
undetectable		 4ky8C-3hgqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 240
LEU A 277
ILE A  48
LEU A  91
THR A  35
 None
 1.04A 4ky8D-3hgqA:
undetectable		 4ky8D-3hgqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 240
LEU A 277
ILE A  48
LEU A  91
THR A  35
 None
 1.04A 4ky8E-3hgqA:
undetectable		 4ky8E-3hgqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 119
LEU A 122
LEU A 125
ILE A 135
VAL A 155
 None
 1.26A 4mk4A-3hgqA:
undetectable		 4mk4A-3hgqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 245
VAL A 266
TYR A 262
GLY A  81
SER A 243
 None
 1.27A 4mm9A-3hgqA:
undetectable		 4mm9A-3hgqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 245
VAL A 266
ALA A 269
GLY A  81
SER A 243
 None
 1.36A 4mmbA-3hgqA:
undetectable		 4mmbA-3hgqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 245
VAL A 266
TYR A 262
GLY A  81
SER A 243
 None
 1.32A 4mmcA-3hgqA:
1.6		 4mmcA-3hgqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 245
VAL A 266
ALA A 269
GLY A  81
SER A 243
 None
 1.27A 4mmeA-3hgqA:
undetectable		 4mmeA-3hgqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 245
VAL A 266
ALA A 269
GLY A  81
SER A 243
 None
 1.30A 4mmeB-3hgqA:
undetectable		 4mmeB-3hgqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 245
VAL A 266
ALA A 269
GLY A  81
SER A 243
 None
 1.26A 4mmfA-3hgqA:
undetectable		 4mmfA-3hgqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 245
VAL A 266
ALA A 269
GLY A  81
SER A 243
 None
 1.26A 4mmfB-3hgqA:
undetectable		 4mmfB-3hgqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 240
LEU A 277
ILE A  48
LEU A  91
THR A  35
 None
 1.08A 4q0dA-3hgqA:
undetectable		 4q0dA-3hgqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 240
LEU A 277
ILE A  48
LEU A  91
THR A  35
 None
 1.08A 4q0dB-3hgqA:
undetectable		 4q0dB-3hgqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 240
LEU A 277
ILE A  48
LEU A  91
THR A  35
 None
 1.08A 4q0dE-3hgqA:
undetectable		 4q0dE-3hgqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 125
GLU A 300
ILE A 287
PRO A 234
 None
 0.96A 4xi3C-3hgqA:
undetectable		 4xi3C-3hgqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 310
TRP A  32
TYR A  31
SER A  28
 None
 1.31A 5b6iA-3hgqA:
undetectable		 5b6iA-3hgqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 310
TRP A  32
TYR A  31
SER A  28
 None
 1.31A 5b6iB-3hgqA:
undetectable		 5b6iB-3hgqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 321
ILE A 272
ARG A 276
ARG A 324
 None
 1.42A 5m67C-3hgqA:
undetectable		 5m67C-3hgqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 4 THR A  45
ASP A  46
ARG A 274
LEU A 277
 None
 1.07A 5tdmA-3hgqA:
undetectable		 5tdmA-3hgqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		5 / 6 THR A  45
ASP A  46
ARG A 274
LEU A 277
ASP A 275
 None
 1.38A 5tdzA-3hgqA:
undetectable		 5tdzA-3hgqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 235
ARG A 237
VAL A 136
ASP A 210
 None
 1.17A 5vlmF-3hgqA:
undetectable		 5vlmF-3hgqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hgq HDA1 COMPLEX SUBUNIT
3
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  90
ILE A 235
MET A 143
GLY A 140
 None
 0.96A 6hd6A-3hgqA:
undetectable		 6hd6A-3hgqA:
13.04