SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hhd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 ILE A 834
TYR A  87
PHE A  65
PHE A 148
 None
 1.25A 1e71M-3hhdA:
undetectable		 1e71M-3hhdA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 LEU A 767
VAL A 578
GLY A 579
ALA A 748
LEU A 749
 None
 1.03A 1e7bA-3hhdA:
undetectable		 1e7bA-3hhdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 PRO A 380
ASN A  25
ASP A  24
TRP A  23
 None
 1.42A 1hpkA-3hhdA:
undetectable		 1hpkA-3hhdA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 LYS A 436
GLU A 439
ALA A 433
THR A 430
 None
 0.94A 1ie4B-3hhdA:
undetectable
1ie4D-3hhdA:
undetectable		 1ie4B-3hhdA:
8.72
1ie4D-3hhdA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A  13
ALA A 339
SER A 164
GLY A  11
LEU A 404
 None
 1.28A 1kglA-3hhdA:
0.0		 1kglA-3hhdA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A  35
ASP A  37
LYS A  53
 None
 0.89A 1lqtB-3hhdA:
undetectable		 1lqtB-3hhdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A  35
ASP A  37
LYS A  53
 None
 0.87A 1lquB-3hhdA:
undetectable		 1lquB-3hhdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 VAL A 229
ILE A 390
GLY A 337
ALA A 339
THR A 325
 None
 1.01A 1r9oA-3hhdA:
undetectable		 1r9oA-3hhdA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.35A 1rl8B-3hhdA:
undetectable		 1rl8B-3hhdA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A 510
LEU A 815
LEU A 423
LEU A 566
 None
 1.11A 1yajD-3hhdA:
undetectable		 1yajD-3hhdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 LEU A 345
ALA A 244
ILE A 246
LEU A 168
ILE A 402
 None
 1.04A 1yi4A-3hhdA:
undetectable		 1yi4A-3hhdA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A 566
LEU A 803
LEU A 797
ILE A 782
 None
 0.95A 1z95A-3hhdA:
undetectable		 1z95A-3hhdA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 189
TYR A 222
SER A 336
 None
 0.62A 2gvcB-3hhdA:
undetectable		 2gvcB-3hhdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 189
TYR A 222
SER A 336
 None
 0.56A 2gvcE-3hhdA:
2.0		 2gvcE-3hhdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 9 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.40A 2idwB-3hhdA:
undetectable		 2idwB-3hhdA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 LEU A 374
LEU A 369
GLU A 270
ARG A 310
 None
 1.05A 2jn3A-3hhdA:
undetectable		 2jn3A-3hhdA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 PHE A 450
LEU A 454
LEU A 424
ARG A 443
 None
 1.03A 2jn3A-3hhdA:
undetectable		 2jn3A-3hhdA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.34A 2nmzA-3hhdA:
undetectable		 2nmzA-3hhdA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A 404
ARG A 405
VAL A 282
ILE A 246
ALA A 280
 None
 1.17A 2q72A-3hhdA:
undetectable		 2q72A-3hhdA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 ARG A  39
SER A 163
VAL A 228
GLY A 227
 None
 0.95A 2qd5B-3hhdA:
undetectable		 2qd5B-3hhdA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.34A 2rkfB-3hhdA:
undetectable		 2rkfB-3hhdA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.36A 2rkgA-3hhdA:
undetectable		 2rkgA-3hhdA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 PHE A 553
SER A 714
PHE A 682
ILE A 717
 None
 1.11A 2v0mD-3hhdA:
undetectable		 2v0mD-3hhdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 ILE A 290
GLY A 389
LEU A 276
PHE A 393
 None
 0.90A 2vctD-3hhdA:
undetectable		 2vctD-3hhdA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A 537
SER A 519
PHE A 516
ASP A 565
 None
 1.23A 2vn1B-3hhdA:
undetectable		 2vn1B-3hhdA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 ILE A 690
PHE A 682
PHE A 553
ILE A 549
 None
 0.85A 2y7wC-3hhdA:
undetectable		 2y7wC-3hhdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 MET A 205
PHE A 395
THR A 297
GLY A 330
LEU A 191
 None
 1.38A 3aodC-3hhdA:
2.1		 3aodC-3hhdA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.26A 3bvbB-3hhdA:
undetectable		 3bvbB-3hhdA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A 567
ALA A 590
ILE A 561
GLY A 583
ILE A 564
 None
 0.96A 3ebzA-3hhdA:
undetectable		 3ebzA-3hhdA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 11 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.33A 3ektC-3hhdA:
undetectable		 3ektC-3hhdA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.34A 3jw2A-3hhdA:
undetectable		 3jw2A-3hhdA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.36A 3jw2B-3hhdA:
undetectable		 3jw2B-3hhdA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.33A 3lzuB-3hhdA:
undetectable		 3lzuB-3hhdA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 175
ALA A 182
THR A 105
VAL A 107
VAL A 109
 None
 1.26A 3r9cA-3hhdA:
undetectable		 3r9cA-3hhdA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.29A 3s54B-3hhdA:
undetectable		 3s54B-3hhdA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.41A 3tl9A-3hhdA:
undetectable		 3tl9A-3hhdA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 10 ALA A 590
ASP A 591
GLY A 579
ILE A 495
LEU A 563
ILE A 564
 None
 1.15A 3ttpA-3hhdA:
undetectable		 3ttpA-3hhdA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 10 ALA A 590
ASP A 591
GLY A 579
ILE A 495
LEU A 563
ILE A 564
 None
 1.13A 3ttpB-3hhdA:
undetectable		 3ttpB-3hhdA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 347
LEU A 348
VAL A 377
ILE A 390
VAL A 388
 None
 1.04A 3w67B-3hhdA:
undetectable		 3w67B-3hhdA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 10 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.37A 4dqfB-3hhdA:
undetectable		 4dqfB-3hhdA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.30A 4jecA-3hhdA:
undetectable		 4jecA-3hhdA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A  59
ASP A 843
ASP A 849
 None
 0.82A 4kicB-3hhdA:
undetectable		 4kicB-3hhdA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 LEU A  26
PRO A 332
SER A 225
GLY A 294
 None
 0.94A 4klrB-3hhdA:
undetectable		 4klrB-3hhdA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 MET A 140
PRO A 334
SER A 163
VAL A 190
 None
 1.41A 4kmmA-3hhdA:
undetectable		 4kmmA-3hhdA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 141
GLY A 110
GLY A 186
LEU A 338
ALA A 156
 None
 1.06A 4lg1C-3hhdA:
undetectable		 4lg1C-3hhdA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 10 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.30A 4ll3A-3hhdA:
undetectable		 4ll3A-3hhdA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		7 / 12 ALA A 160
CYH A 161
PHE A 200
HIS A 293
THR A 295
HIS A 331
GLY A 394
 None
 0.57A 4ls7A-3hhdA:
47.5		 4ls7A-3hhdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 CYH A 161
PHE A 200
HIS A 293
HIS A 331
GLY A 394
PHE A 395
 None
 1.08A 4ls7A-3hhdA:
47.5		 4ls7A-3hhdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		7 / 12 ALA A 160
CYH A 161
PHE A 200
HIS A 293
THR A 295
HIS A 331
GLY A 394
 None
 0.56A 4ls7A-3hhdA:
47.5
4ls7B-3hhdA:
47.4		 4ls7A-3hhdA:
18.79
4ls7B-3hhdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 CYH A 161
PHE A 200
HIS A 293
HIS A 331
GLY A 394
PHE A 395
 None
 1.09A 4ls7A-3hhdA:
47.5
4ls7B-3hhdA:
47.4		 4ls7A-3hhdA:
18.79
4ls7B-3hhdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 GLY A 428
SER A 427
ALA A 426
PHE A 467
 None
 1.03A 4m93B-3hhdA:
undetectable
4m93C-3hhdA:
undetectable		 4m93B-3hhdA:
13.05
4m93C-3hhdA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ALA A 160
GLN A 269
GLY A 266
 None
 0.55A 4odoC-3hhdA:
undetectable		 4odoC-3hhdA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 171
GLN A 169
THR A 253
THR A 251
LEU A 157
 None
 1.27A 4qzuA-3hhdA:
undetectable		 4qzuA-3hhdA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 LEU A 454
GLY A 441
ASP A 447
SER A 445
ILE A 830
 None
 1.12A 4xj7C-3hhdA:
undetectable
4xj7D-3hhdA:
undetectable		 4xj7C-3hhdA:
14.21
4xj7D-3hhdA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 ARG A 515
LEU A 566
LEU A 797
ILE A 800
ALA A 814
 None
 1.30A 4z69A-3hhdA:
undetectable		 4z69A-3hhdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 813
SER A 452
ARG A 240
 None
 0.96A 5b2qA-3hhdA:
undetectable		 5b2qA-3hhdA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 335
GLY A 187
SER A 164
LEU A  83
GLU A  84
 None
 1.07A 5c0oH-3hhdA:
3.0		 5c0oH-3hhdA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.27A 5e5kA-3hhdA:
undetectable		 5e5kA-3hhdA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 ILE A   6
ALA A 183
VAL A 185
VAL A   4
 None
 0.86A 5eclD-3hhdA:
undetectable		 5eclD-3hhdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 338
ALA A 230
LEU A 144
ILE A  90
THR A  86
GLY A 110
 None
 1.19A 5h2uC-3hhdA:
undetectable		 5h2uC-3hhdA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 800
LEU A 815
SER A 509
PHE A 796
GLY A 799
 None
 1.37A 5il1A-3hhdA:
undetectable		 5il1A-3hhdA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 THR A 827
ALA A   7
LEU A 238
LEU A 100
GLY A  93
 None
 1.09A 5jglA-3hhdA:
undetectable		 5jglA-3hhdA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 CYH A 212
LYS A 213
HIS A 358
 None
 1.17A 5js5A-3hhdA:
undetectable		 5js5A-3hhdA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 567
ALA A 590
ASP A 591
GLY A 579
ILE A 495
ILE A 564
 None
 1.29A 5t2zB-3hhdA:
undetectable		 5t2zB-3hhdA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 4 LEU A 829
LEU A 346
SER A  10
ALA A 342
 None
 1.08A 5uunA-3hhdA:
undetectable		 5uunA-3hhdA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 ALA A   7
LEU A 232
VAL A 231
VAL A   4
ILE A 175
 None
 1.13A 5v02B-3hhdA:
undetectable
5v02R-3hhdA:
undetectable		 5v02B-3hhdA:
7.45
5v02R-3hhdA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 549
ASN A 735
LEU A 601
ALA A 602
LEU A 698
 None
 1.09A 5y7pB-3hhdA:
undetectable		 5y7pB-3hhdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 549
ASN A 735
LEU A 601
ALA A 602
LEU A 698
 None
 1.08A 5y7pD-3hhdA:
undetectable		 5y7pD-3hhdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 549
ASN A 735
LEU A 601
ALA A 602
LEU A 698
 None
 1.07A 5y7pG-3hhdA:
undetectable		 5y7pG-3hhdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 549
ASN A 735
LEU A 601
ALA A 602
LEU A 698
 None
 1.13A 5y7pH-3hhdA:
undetectable		 5y7pH-3hhdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 ASN A 328
TYR A 289
VAL A 383
LEU A 348
 None
 1.31A 6a7pA-3hhdA:
undetectable		 6a7pA-3hhdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 339
THR A 325
LEU A  26
ILE A  27
LEU A 346
 None
 1.14A 6aybA-3hhdA:
undetectable		 6aybA-3hhdA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 ALA A 340
ALA A 292
ALA A 214
GLY A 294
SER A 327
 None
 1.18A 6bklE-3hhdA:
undetectable
6bklF-3hhdA:
undetectable
6bklG-3hhdA:
undetectable
6bklH-3hhdA:
undetectable		 6bklE-3hhdA:
2.45
6bklF-3hhdA:
2.45
6bklG-3hhdA:
2.45
6bklH-3hhdA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 LEU A 451
ASP A  92
ILE A 834
 None
 0.65A 6dh0B-3hhdA:
undetectable		 6dh0B-3hhdA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3hhd FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 ASP A  92
SER A 831
TYR A 243
GLY A 351
 None
 0.91A 6giqL-3hhdA:
undetectable
6giqP-3hhdA:
undetectable
6giqT-3hhdA:
undetectable		 6giqL-3hhdA:
19.65
6giqP-3hhdA:
13.38
6giqT-3hhdA:
5.45