SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 11 LEU A 219
ALA A 169
GLY A 162
ILE A 163
ILE A 222
 None
 0.93A 1c6yA-3hheA:
undetectable		 1c6yA-3hheA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		4 / 7 LEU A  45
LEU A  59
GLY A  61
LEU A  68
 None
None
None
CL  A 499 ( 4.7A)
 0.80A 1gtiA-3hheA:
undetectable		 1gtiA-3hheA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		4 / 7 ASP A 107
GLY A 150
ILE A 209
PRO A 111
 5RP  A 501 (-2.6A)
None
None
None
 0.91A 2fxdB-3hheA:
undetectable		 2fxdB-3hheA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 9 VAL A  53
GLY A 105
LEU A 101
ASP A 102
ASP A 104
 None
5RP  A 501 (-3.5A)
None
None
5RP  A 501 (-4.0A)
 1.43A 2j2pB-3hheA:
undetectable
2j2pC-3hheA:
undetectable		 2j2pB-3hheA:
23.85
2j2pC-3hheA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		3 / 3 SER A  76
GLY A  48
GLY A  50
 None
None
5RP  A 501 ( 3.9A)
 0.51A 3bogA-3hheA:
undetectable
3bogC-3hheA:
undetectable		 3bogA-3hheA:
undetectable
3bogC-3hheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 LEU A 177
ALA A 173
GLY A 229
ILE A 183
THR A 166
 None
 0.91A 3c6gA-3hheA:
undetectable		 3c6gA-3hheA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 GLY A 229
GLY A 118
ILE A 156
LEU A 115
GLU A 108
 None
5RP  A 501 (-3.4A)
None
None
None
 1.03A 3ckkA-3hheA:
undetectable		 3ckkA-3hheA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		4 / 8 ASP A  42
GLY A  67
PRO A  89
THR A  71
 None
 0.73A 3el9A-3hheA:
undetectable		 3el9A-3hheA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		6 / 11 GLY A 105
ALA A 106
ASP A 107
LEU A 234
PRO A 252
ILE A 109
 5RP  A 501 (-3.5A)
None
5RP  A 501 (-2.6A)
None
None
None
 1.48A 3em4A-3hheA:
undetectable		 3em4A-3hheA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 9 ARG A 237
ALA A 106
ASP A 107
LEU A 234
ILE A 109
 None
None
5RP  A 501 (-2.6A)
None
None
 1.14A 3em4B-3hheA:
undetectable		 3em4B-3hheA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		6 / 11 ARG A 237
GLY A 105
ALA A 106
ASP A 107
LEU A 234
ILE A 109
 None
5RP  A 501 (-3.5A)
None
5RP  A 501 (-2.6A)
None
None
 1.08A 3em4U-3hheA:
undetectable		 3em4U-3hheA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		6 / 11 GLY A 105
ALA A 106
ASP A 107
LEU A 234
PRO A 252
ILE A 109
 5RP  A 501 (-3.5A)
None
5RP  A 501 (-2.6A)
None
None
None
 1.48A 3em4U-3hheA:
undetectable		 3em4U-3hheA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 ILE A 109
ASP A 203
ILE A 201
ASP A 107
PHE A 152
 None
None
None
5RP  A 501 (-2.6A)
None
 1.48A 3phaB-3hheA:
undetectable		 3phaB-3hheA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 ILE A 109
ASP A 203
ILE A 201
ASP A 107
PHE A 152
 None
None
None
5RP  A 501 (-2.6A)
None
 1.49A 3phaD-3hheA:
undetectable		 3phaD-3hheA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		4 / 4 GLY A 207
GLY A 150
THR A 148
LEU A 210
 None
 0.90A 3si7C-3hheA:
undetectable
3si7D-3hheA:
undetectable		 3si7C-3hheA:
23.81
3si7D-3hheA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 11 LEU A 219
ALA A 169
GLY A 162
ILE A 163
ILE A 222
 None
 0.96A 4dqeA-3hheA:
undetectable		 4dqeA-3hheA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 11 LEU A 219
ALA A 169
GLY A 162
ILE A 163
ILE A 222
 None
 0.96A 4njtA-3hheA:
undetectable		 4njtA-3hheA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 11 LEU A 219
ALA A 169
GLY A 162
ILE A 163
ILE A 222
 None
 0.91A 4njtC-3hheA:
undetectable		 4njtC-3hheA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		3 / 3 SER A 245
ALA A 241
VAL A 240
 None
 0.60A 4o2bA-3hheA:
undetectable		 4o2bA-3hheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		3 / 3 SER A 245
ALA A 241
VAL A 240
 None
 0.52A 4o2bC-3hheA:
undetectable		 4o2bC-3hheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 ALA A 130
SER A 133
GLY A  46
ALA A 140
GLY A 105
 None
None
None
None
5RP  A 501 (-3.5A)
 1.29A 4r29B-3hheA:
undetectable		 4r29B-3hheA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		3 / 3 SER A 245
ALA A 241
VAL A 240
 None
 0.46A 4x1iA-3hheA:
undetectable		 4x1iA-3hheA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 LEU A  45
ILE A  47
ILE A  90
VAL A  88
LEU A  36
 None
 0.94A 4y0pA-3hheA:
undetectable		 4y0pA-3hheA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 LEU A  45
ILE A  47
ILE A  90
VAL A  88
LEU A  36
 None
 0.93A 4y0sA-3hheA:
undetectable		 4y0sA-3hheA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		4 / 6 SER A 216
HIS A 228
LEU A 232
LEU A 234
 None
 1.34A 5dzke-3hheA:
undetectable
5dzks-3hheA:
undetectable		 5dzke-3hheA:
23.44
5dzks-3hheA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		3 / 3 SER A 245
ALA A 241
VAL A 240
 None
 0.44A 5eypA-3hheA:
undetectable		 5eypA-3hheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 ASP A 107
LEU A 234
GLY A 119
GLY A 118
GLY A  50
 5RP  A 501 (-2.6A)
None
5RP  A 501 (-4.0A)
5RP  A 501 (-3.4A)
5RP  A 501 ( 3.9A)
 0.99A 5kb5A-3hheA:
undetectable		 5kb5A-3hheA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 LEU A 219
ALA A 169
GLY A 162
ILE A 163
ILE A 222
 None
 0.95A 5kqyA-3hheA:
undetectable		 5kqyA-3hheA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		5 / 12 LEU A 219
ALA A 169
GLY A 162
ILE A 163
ILE A 222
 None
 0.87A 5t2zB-3hheA:
undetectable		 5t2zB-3hheA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		4 / 8 GLY A 229
ARG A 186
ASP A 203
ASP A 107
 None
None
None
5RP  A 501 (-2.6A)
 1.03A 5vlmB-3hheA:
undetectable		 5vlmB-3hheA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		3 / 3 SER A 245
ALA A 241
VAL A 240
 None
 0.43A 5xiwC-3hheA:
2.1		 5xiwC-3hheA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A
(Bartonella
henselae) 		3 / 3 LEU A 149
ASP A 203
ILE A 156
 None
 0.60A 6dh0B-3hheA:
undetectable		 6dh0B-3hheA:
23.08