SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hhf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 0.96A 1cqeA-3hhfB:
undetectable		 1cqeA-3hhfB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 0.96A 1cqeB-3hhfB:
undetectable		 1cqeB-3hhfB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 ALA B 112
LEU B 126
PHE B 285
SER B  99
LEU B 159
 None
 1.16A 1u72A-3hhfB:
2.3		 1u72A-3hhfB:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 0.87A 2aylA-3hhfB:
undetectable		 2aylA-3hhfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 0.94A 2aylB-3hhfB:
undetectable		 2aylB-3hhfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		4 / 5 ARG B 138
ASP B  98
ALA B 143
ILE B 136
 None
 1.07A 2qhfA-3hhfB:
undetectable		 2qhfA-3hhfB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 0.98A 3n8wA-3hhfB:
undetectable		 3n8wA-3hhfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		3 / 3 VAL B  97
SER B  99
LEU B 108
 None
 0.65A 3n8xA-3hhfB:
undetectable		 3n8xA-3hhfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 0.95A 3n8zA-3hhfB:
undetectable		 3n8zA-3hhfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 1.05A 3nt1A-3hhfB:
undetectable		 3nt1A-3hhfB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 1.07A 3nt1B-3hhfB:
undetectable		 3nt1B-3hhfB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 ILE B 167
LEU B 226
ILE B 214
PRO B 216
ASN B 200
 None
 0.99A 4gh8A-3hhfB:
undetectable		 4gh8A-3hhfB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 1.07A 5jvzA-3hhfB:
undetectable		 5jvzA-3hhfB:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL B 237
LEU B 191
LEU B 239
GLY B 233
LEU B 253
 None
 1.07A 5jvzB-3hhfB:
undetectable		 5jvzB-3hhfB:
16.91