SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 0.99A 1cqeA-3hhgA:
undetectable		 1cqeA-3hhgA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 0.99A 1cqeB-3hhgA:
undetectable		 1cqeB-3hhgA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 ARG A 118
PHE A 285
LEU A 144
LEU A 293
LEU A 111
 None
 1.39A 1p33A-3hhgA:
undetectable		 1p33A-3hhgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 ALA A 112
LEU A 126
PHE A 285
SER A  99
LEU A 159
 None
 1.22A 1u72A-3hhgA:
undetectable		 1u72A-3hhgA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 0.91A 2aylA-3hhgA:
undetectable		 2aylA-3hhgA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 0.96A 2aylB-3hhgA:
undetectable		 2aylB-3hhgA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 1.01A 3n8wA-3hhgA:
undetectable		 3n8wA-3hhgA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 0.98A 3n8zA-3hhgA:
undetectable		 3n8zA-3hhgA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 1.06A 3nt1A-3hhgA:
undetectable		 3nt1A-3hhgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 LEU A 173
ILE A 254
ILE A 167
LEU A 256
VAL A 237
 None
 0.95A 4nkvB-3hhgA:
undetectable		 4nkvB-3hhgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		4 / 5 LEU A 159
PHE A 268
LEU A 289
PHE A 285
 None
 1.24A 5iy5P-3hhgA:
undetectable
5iy5W-3hhgA:
undetectable		 5iy5P-3hhgA:
21.43
5iy5W-3hhgA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 1.07A 5jvzA-3hhgA:
undetectable		 5jvzA-3hhgA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		5 / 12 VAL A 237
LEU A 191
LEU A 239
GLY A 233
LEU A 253
 None
 1.06A 5jvzB-3hhgA:
undetectable		 5jvzB-3hhgA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		4 / 6 VAL A 127
SER A 125
ARG A 281
PHE A 285
 None
 1.08A 5jw1B-3hhgA:
undetectable		 5jw1B-3hhgA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		4 / 8 ASP A 161
ARG A  68
HIS A 158
GLU A  61
 None
 1.06A 6mn4A-3hhgA:
undetectable		 6mn4A-3hhgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		4 / 8 ASP A 161
ARG A  68
HIS A 158
GLU A  61
 None
 1.09A 6mn4B-3hhgA:
undetectable		 6mn4B-3hhgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY
(Neisseria
meningitidis) 		4 / 8 ASP A 161
ARG A  68
HIS A 158
GLU A  61
 None
 1.17A 6mn4D-3hhgA:
undetectable		 6mn4D-3hhgA:
23.36