SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hhr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		4 / 8 SER B 145
VAL B 144
TYR B 208
VAL B 231
 None
 0.97A 1fduB-3hhrB:
undetectable		 1fduB-3hhrB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		5 / 11 SER A  55
PHE A  54
PHE A 146
LEU A  20
VAL A 110
 None
 1.30A 1q23G-3hhrA:
undetectable		 1q23G-3hhrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		5 / 12 GLN B 216
ALA B 163
GLY B 223
ASP B 132
LEU B 172
 None
 1.18A 2nv4A-3hhrB:
undetectable		 2nv4A-3hhrB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		3 / 3 ARG B  43
GLU B  44
GLN B 216
 None
 1.01A 2p16A-3hhrB:
undetectable		 2p16A-3hhrB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		4 / 8 GLN A 122
MET A 125
ILE A 121
SER A  85
 None
 1.06A 2xytE-3hhrA:
undetectable		 2xytE-3hhrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		4 / 8 GLN A 122
MET A 125
ILE A 121
SER A  85
 None
 1.11A 2xytH-3hhrA:
undetectable		 2xytH-3hhrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		4 / 7 GLN A 122
MET A 125
ILE A 121
SER A  85
 None
 1.21A 2xytI-3hhrA:
undetectable		 2xytI-3hhrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hhr HUMAN GROWTH HORMONE
HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR B 107
ASP B 126
ASP A 169
 None
 0.91A 3ou6B-3hhrB:
undetectable		 3ou6B-3hhrB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		4 / 7 LEU A 117
LEU A 124
VAL A 185
SER A 188
 None
 1.00A 3r9vA-3hhrA:
undetectable
3r9vB-3hhrA:
3.5		 3r9vA-3hhrA:
20.48
3r9vB-3hhrA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		5 / 10 LEU B  66
GLU B  82
THR B  51
TRP B  50
PHE B  67
 None
 1.42A 4driB-3hhrB:
undetectable		 4driB-3hhrB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		5 / 11 LEU A 117
HIS A  21
LEU A  20
ALA A  17
LEU A 177
 None
 1.12A 4p65C-3hhrA:
undetectable
4p65D-3hhrA:
undetectable
4p65J-3hhrA:
undetectable
4p65L-3hhrA:
undetectable		 4p65C-3hhrA:
7.89
4p65D-3hhrA:
10.29
4p65J-3hhrA:
10.29
4p65L-3hhrA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		5 / 11 LEU A 117
HIS A  21
LEU A  20
ALA A  17
LEU A 177
 None
 0.98A 4p65E-3hhrA:
undetectable
4p65F-3hhrA:
undetectable
4p65J-3hhrA:
undetectable
4p65L-3hhrA:
undetectable		 4p65E-3hhrA:
7.89
4p65F-3hhrA:
10.29
4p65J-3hhrA:
10.29
4p65L-3hhrA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		5 / 11 LEU A 177
LEU A 117
HIS A  21
LEU A  20
ALA A  17
 None
 1.06A 4p65B-3hhrA:
undetectable
4p65D-3hhrA:
undetectable
4p65G-3hhrA:
undetectable
4p65H-3hhrA:
undetectable		 4p65B-3hhrA:
10.29
4p65D-3hhrA:
10.29
4p65G-3hhrA:
7.89
4p65H-3hhrA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 3hhr HUMAN GROWTH HORMONE
HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		3 / 3 GLN A  22
HIS A  18
ARG B 217
 None
 1.20A 4qyqA-3hhrA:
0.0		 4qyqA-3hhrA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 3hhr HUMAN GROWTH HORMONE
HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		3 / 3 GLN A  22
HIS A  18
ARG B 217
 None
 1.20A 4qyqB-3hhrA:
undetectable		 4qyqB-3hhrA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		5 / 9 LEU A  23
LEU A 114
LEU A  20
ARG A  19
ARG A  16
 None
 1.30A 4x30A-3hhrA:
undetectable		 4x30A-3hhrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		3 / 3 TYR A  42
LYS A  38
LYS A  41
 None
 1.31A 5dbyA-3hhrA:
undetectable		 5dbyA-3hhrA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		3 / 3 THR B  45
PRO B  41
ASP B 132
 None
 0.86A 5l8dB-3hhrB:
undetectable		 5l8dB-3hhrB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		3 / 3 THR B  45
PRO B  41
ASP B 132
 None
 0.86A 5mwuB-3hhrB:
undetectable		 5mwuB-3hhrB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)
(Homo
sapiens) 		5 / 12 GLY B 115
SER B 113
LYS B  62
GLU B 120
LEU B 111
 None
 1.32A 5nwvA-3hhrB:
undetectable		 5nwvA-3hhrB:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		4 / 6 LEU A   6
SER A   7
PHE A  10
ASP A  11
 None
 0.72A 5om3A-3hhrA:
undetectable
5om3B-3hhrA:
undetectable		 5om3A-3hhrA:
19.21
5om3B-3hhrA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3hhr HUMAN GROWTH HORMONE
(Homo
sapiens) 		3 / 3 PHE A 176
ASP A 171
LEU A  15
 None
 0.78A 5uhbC-3hhrA:
undetectable		 5uhbC-3hhrA:
9.81