SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.70A 1c9sI-3hhsB:
undetectable
1c9sJ-3hhsB:
undetectable		 1c9sI-3hhsB:
8.46
1c9sJ-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.72A 1c9sU-3hhsB:
undetectable
1c9sV-3hhsB:
undetectable		 1c9sU-3hhsB:
8.46
1c9sV-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 6 VAL A 438
ASN A 498
ILE A 548
ASN A 546
 None
 0.89A 1e06A-3hhsA:
undetectable		 1e06A-3hhsA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 9 VAL B 486
ILE B 542
VAL B 501
ASP B 529
ILE B 503
 None
 1.42A 1gebA-3hhsB:
undetectable		 1gebA-3hhsB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 9 VAL A 493
ILE A 548
VAL A 507
ASP A 535
ILE A 509
 None
 1.36A 1gebA-3hhsA:
undetectable		 1gebA-3hhsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.69A 1gtnA-3hhsB:
undetectable
1gtnB-3hhsB:
undetectable		 1gtnA-3hhsB:
8.46
1gtnB-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 12 THR B 447
PHE B 483
SER B 671
VAL B 248
VAL B 600
 None
 1.30A 1q23C-3hhsB:
undetectable		 1q23C-3hhsB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 THR B 447
PHE B 483
SER B 671
VAL B 248
VAL B 600
 None
 1.29A 1q23F-3hhsB:
undetectable		 1q23F-3hhsB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 THR B 447
PHE B 483
SER B 671
VAL B 248
VAL B 600
 None
 1.31A 1q23I-3hhsB:
undetectable		 1q23I-3hhsB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 HIS B 406
HIS B 366
HIS B 239
 CU  B   1 (-3.1A)
CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
 0.72A 1rjoA-3hhsB:
undetectable		 1rjoA-3hhsB:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 HIS A 408
HIS A 368
HIS A 245
 CU  A 697 (-3.1A)
CU  A 697 (-3.2A)
CU  A 696 (-3.2A)
 0.72A 1rjoA-3hhsA:
undetectable		 1rjoA-3hhsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.69A 1utdB-3hhsB:
undetectable
1utdC-3hhsB:
undetectable		 1utdB-3hhsB:
8.46
1utdC-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.71A 1utdF-3hhsB:
undetectable
1utdG-3hhsB:
undetectable		 1utdF-3hhsB:
8.46
1utdG-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.69A 1utdI-3hhsB:
undetectable
1utdJ-3hhsB:
undetectable		 1utdI-3hhsB:
8.46
1utdJ-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.70A 1utdJ-3hhsB:
undetectable
1utdK-3hhsB:
undetectable		 1utdJ-3hhsB:
8.46
1utdK-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 ASP A 235
TYR A 644
GLU A 239
 None
 0.87A 1vm1A-3hhsA:
undetectable		 1vm1A-3hhsA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 HIS A 408
HIS A 368
HIS A 245
 CU  A 697 (-3.1A)
CU  A 697 (-3.2A)
CU  A 696 (-3.2A)
 0.73A 1w2zA-3hhsA:
undetectable		 1w2zA-3hhsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 PHE A 667
PHE A 609
MET A 611
VAL A 507
 None
 1.09A 1wrlA-3hhsA:
undetectable
1wrlB-3hhsA:
undetectable		 1wrlA-3hhsA:
8.68
1wrlB-3hhsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 MET A 673
ASN A 663
GLN A 527
 None
 1.06A 1xoqB-3hhsA:
undetectable		 1xoqB-3hhsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 TYR B 485
HIS B 480
GLU B 482
HIS B 586
 None
 0.98A 2bnnA-3hhsB:
undetectable
2bnnB-3hhsB:
undetectable		 2bnnA-3hhsB:
14.81
2bnnB-3hhsB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ASN B  79
ARG B 283
ASP B 302
 None
 0.99A 2qe6B-3hhsB:
undetectable		 2qe6B-3hhsB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 12 ALA B 506
PRO B 507
VAL B 600
PHE B 483
ILE B 590
 None
 1.29A 2v95A-3hhsB:
undetectable		 2v95A-3hhsB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 HIS B 209
MET B 238
MET B 397
 CU  B 686 (-3.1A)
None
None
 1.05A 2vj1A-3hhsB:
undetectable		 2vj1A-3hhsB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 10 ALA B 394
ASP B 392
SER B 130
PHE B 151
THR B 395
 None
 1.08A 2w9sD-3hhsB:
undetectable		 2w9sD-3hhsB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 10 ALA B 394
ASP B 392
SER B 130
PHE B 151
THR B 395
 None
 1.08A 2w9sF-3hhsB:
undetectable		 2w9sF-3hhsB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 366
HIS B 370
VAL B 409
HIS B 406
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
None
CU  B   1 (-3.1A)
 1.01A 2wkoF-3hhsB:
3.9		 2wkoF-3hhsB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 368
HIS A 372
VAL A 411
HIS A 408
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.1A)
 1.00A 2wkoF-3hhsA:
3.0		 2wkoF-3hhsA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 12 LEU A  79
HIS A  92
SER A  91
VAL A 307
SER A 388
 None
 1.44A 2xpwA-3hhsA:
0.0		 2xpwA-3hhsA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.64A 2zweA-3hhsB:
9.1
2zweB-3hhsB:
undetectable		 2zweA-3hhsB:
18.02
2zweB-3hhsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.08A 2zweA-3hhsB:
9.1
2zweB-3hhsB:
undetectable		 2zweA-3hhsB:
18.02
2zweB-3hhsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.67A 2zweA-3hhsA:
8.1
2zweB-3hhsA:
undetectable		 2zweA-3hhsA:
18.88
2zweB-3hhsA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.67A 2zwfA-3hhsB:
10.1
2zwfB-3hhsB:
undetectable		 2zwfA-3hhsB:
18.02
2zwfB-3hhsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.05A 2zwfA-3hhsB:
10.1
2zwfB-3hhsB:
undetectable		 2zwfA-3hhsB:
18.02
2zwfB-3hhsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 366
HIS B 239
HIS B 209
VAL B 389
ASP B 399
 CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
CU  B 686 (-3.1A)
None
None
 1.46A 2zwfA-3hhsB:
10.1
2zwfB-3hhsB:
undetectable		 2zwfA-3hhsB:
18.02
2zwfB-3hhsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.71A 2zwfA-3hhsA:
8.1
2zwfB-3hhsA:
undetectable		 2zwfA-3hhsA:
18.88
2zwfB-3hhsA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.66A 2zwgA-3hhsB:
10.1
2zwgB-3hhsB:
undetectable		 2zwgA-3hhsB:
18.02
2zwgB-3hhsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.12A 2zwgA-3hhsB:
10.1
2zwgB-3hhsB:
undetectable		 2zwgA-3hhsB:
18.02
2zwgB-3hhsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 366
HIS B 239
HIS B 209
VAL B 389
ASP B 399
 CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
CU  B 686 (-3.1A)
None
None
 1.45A 2zwgA-3hhsB:
10.1
2zwgB-3hhsB:
undetectable		 2zwgA-3hhsB:
18.02
2zwgB-3hhsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.71A 2zwgA-3hhsA:
8.0
2zwgB-3hhsA:
undetectable		 2zwgA-3hhsA:
18.88
2zwgB-3hhsA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 12 LEU A 357
PHE A 224
LEU A  87
LEU A 220
TYR A 132
 None
 1.49A 3adsA-3hhsA:
undetectable		 3adsA-3hhsA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta;
Manduca
sexta) 		3 / 3 PRO A 157
LEU A 285
ARG B 165
 None
 0.66A 3aqiB-3hhsA:
undetectable		 3aqiB-3hhsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 VAL A 264
GLN A 416
PHE A 267
ARG A 528
 None
 1.30A 3bjwB-3hhsA:
undetectable		 3bjwB-3hhsA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 4 THR B 493
VAL B 489
GLY B 499
THR B 500
 None
 1.03A 3cflA-3hhsB:
undetectable		 3cflA-3hhsB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 GLU B 556
HIS B 587
HIS B 586
 None
 0.78A 3co4A-3hhsB:
undetectable		 3co4A-3hhsB:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 THR B 500
SER B 607
PHE B 504
 None
 0.83A 3d4sA-3hhsB:
undetectable		 3d4sA-3hhsB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 PHE A 403
PHE A 267
PHE A 374
SER A 375
 None
 1.38A 3hggA-3hhsA:
undetectable		 3hggA-3hhsA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 HIS B 406
HIS B 366
HIS B 239
 CU  B   1 (-3.1A)
CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
 0.74A 3hiiA-3hhsB:
undetectable		 3hiiA-3hhsB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 GLU A 239
ASP A 235
ASP A 646
 None
 0.76A 3jb2A-3hhsA:
undetectable		 3jb2A-3hhsA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 ARG B 165
ARG B 468
GLY B 460
GLU B  25
 None
 1.28A 3k9fA-3hhsB:
undetectable
3k9fB-3hhsB:
undetectable
3k9fC-3hhsB:
undetectable		 3k9fA-3hhsB:
21.66
3k9fB-3hhsB:
21.66
3k9fC-3hhsB:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 244
GLN B 257
MET B 251
ILE B 526
 None
 1.12A 3kvvA-3hhsB:
undetectable		 3kvvA-3hhsB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 244
GLN B 257
MET B 251
ILE B 526
 None
 1.13A 3kvvB-3hhsB:
undetectable		 3kvvB-3hhsB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 244
GLN B 257
MET B 251
ILE B 526
 None
 1.11A 3kvvC-3hhsB:
undetectable		 3kvvC-3hhsB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 244
GLN B 257
MET B 251
ILE B 526
 None
 1.08A 3kvvD-3hhsB:
undetectable		 3kvvD-3hhsB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 244
GLN B 257
MET B 251
ILE B 526
 None
 1.10A 3kvvE-3hhsB:
undetectable		 3kvvE-3hhsB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 244
GLN B 257
MET B 251
ILE B 526
 None
 1.11A 3kvvF-3hhsB:
undetectable		 3kvvF-3hhsB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 ALA A 169
ARG A 170
ILE A 185
LEU A 466
LEU A 161
 None
 1.14A 3kw2A-3hhsA:
undetectable		 3kw2A-3hhsA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLU B  25
PRO B  15
ARG B  14
GLY B  24
 None
 1.21A 3oxvA-3hhsB:
undetectable		 3oxvA-3hhsB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 HIS A 219
SER A  86
ASN A 369
 CU  A 696 (-3.3A)
None
None
 0.70A 3s8pB-3hhsA:
undetectable		 3s8pB-3hhsA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 PRO B  33
ILE B  32
SER B 114
ARG B 119
 None
 1.01A 3sfeB-3hhsB:
undetectable
3sfeC-3hhsB:
1.4		 3sfeB-3hhsB:
16.76
3sfeC-3hhsB:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 10 THR B 447
PHE B 483
SER B 671
VAL B 248
VAL B 600
 None
 1.29A 3u9fE-3hhsB:
undetectable		 3u9fE-3hhsB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 10 THR B 447
PHE B 483
SER B 671
VAL B 248
VAL B 600
 None
 1.23A 3u9fD-3hhsB:
0.0
3u9fF-3hhsB:
0.0		 3u9fD-3hhsB:
14.99
3u9fF-3hhsB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ASP B 399
GLU B 270
GLY B 271
 None
 0.62A 3w9tA-3hhsB:
undetectable		 3w9tA-3hhsB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 THR B 146
LEU B 207
GLY B 204
VAL B 457
 None
 0.78A 4c9nA-3hhsB:
undetectable		 4c9nA-3hhsB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 244
GLN B 257
MET B 251
ILE B 526
 None
 1.16A 4e1vF-3hhsB:
undetectable		 4e1vF-3hhsB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ARG B 299
HIS B 381
TYR B 375
 None
 1.10A 4fu8A-3hhsB:
undetectable		 4fu8A-3hhsB:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 ARG A 305
HIS A 383
TYR A 377
 None
 1.15A 4fu8A-3hhsA:
undetectable		 4fu8A-3hhsA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ARG B 299
HIS B 381
TYR B 375
 None
 1.07A 4fu9A-3hhsB:
undetectable		 4fu9A-3hhsB:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 ARG A 305
HIS A 383
TYR A 377
 None
 1.12A 4fu9A-3hhsA:
undetectable		 4fu9A-3hhsA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 SER A 473
ARG A 170
LEU A 470
ASP A 471
 None
 1.48A 4ifxA-3hhsA:
undetectable		 4ifxA-3hhsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 SER A 473
ARG A 170
LEU A 470
ASP A 471
 None
 1.47A 4ig1A-3hhsA:
undetectable		 4ig1A-3hhsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 ALA A  76
PRO A  74
LEU A 125
LEU A 129
 None
 1.07A 4iomA-3hhsA:
undetectable		 4iomA-3hhsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 PRO A 359
VAL A 333
ALA A 327
TYR A 320
 None
 1.12A 4lb2A-3hhsA:
undetectable		 4lb2A-3hhsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 ASP A 471
ARG A 170
PHE A 472
SER A 473
 None
 1.37A 4o4dA-3hhsA:
undetectable		 4o4dA-3hhsA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 7 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
ALA B 396
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.69A 4p6sA-3hhsB:
9.6		 4p6sA-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 7 HIS B 366
HIS B 370
HIS B 209
HIS B 213
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
 0.78A 4p6sA-3hhsB:
9.6		 4p6sA-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 7 HIS B 370
HIS B 406
HIS B 209
ALA B 396
 CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
CU  B 686 (-3.1A)
None
 0.90A 4p6sA-3hhsB:
9.6		 4p6sA-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 7 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.70A 4p6sA-3hhsA:
7.3		 4p6sA-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 7 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
 0.71A 4p6sB-3hhsB:
9.7		 4p6sB-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 7 HIS B 366
HIS B 370
HIS B 209
HIS B 213
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
 0.74A 4p6sB-3hhsB:
9.7		 4p6sB-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 7 HIS B 370
HIS B 366
HIS B 213
HIS B 209
 CU  B   1 (-3.2A)
CU  B   1 (-3.3A)
CU  B 686 (-3.3A)
CU  B 686 (-3.1A)
 0.95A 4p6sB-3hhsB:
9.7		 4p6sB-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 7 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.68A 4p6sB-3hhsA:
7.3		 4p6sB-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 HIS A 368
HIS A 372
HIS A 215
HIS A 219
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
 0.76A 4p6sB-3hhsA:
7.3		 4p6sB-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 HIS A 372
HIS A 368
HIS A 219
HIS A 215
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 696 (-3.3A)
CU  A 696 (-3.2A)
 0.94A 4p6sB-3hhsA:
7.3		 4p6sB-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 12 HIS B 370
PHE B 402
ILE B 242
HIS B 406
GLU B 351
 CU  B   1 (-3.2A)
CU  B   1 ( 4.8A)
None
CU  B   1 (-3.1A)
None
 1.20A 4r88A-3hhsB:
undetectable		 4r88A-3hhsB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 12 HIS B 370
PHE B 402
ILE B 242
HIS B 406
GLU B 351
 CU  B   1 (-3.2A)
CU  B   1 ( 4.8A)
None
CU  B   1 (-3.1A)
None
 1.23A 4r88C-3hhsB:
undetectable		 4r88C-3hhsB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 MET B 368
GLN B 317
TYR B 362
 None
 0.84A 4udcA-3hhsB:
undetectable		 4udcA-3hhsB:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 12 ARG A 237
ARG A 321
ILE A 324
GLU A 325
ILE A 414
 None
 1.02A 4uw0A-3hhsA:
undetectable		 4uw0A-3hhsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 ARG B  63
ILE B  62
GLN B 110
ASP B 105
 None
 1.12A 4w5qA-3hhsB:
undetectable		 4w5qA-3hhsB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 10 ASP B 364
VAL B 409
PHE B 235
SER B 352
GLY B 347
 None
 1.43A 4xp1A-3hhsB:
undetectable		 4xp1A-3hhsB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 10 ASP B 364
VAL B 409
PHE B 235
SER B 352
GLY B 347
 None
 1.29A 4xpbA-3hhsB:
0.7		 4xpbA-3hhsB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ASP B 647
ARG B 648
TYR B 644
 None
 0.80A 5a7mA-3hhsB:
undetectable		 5a7mA-3hhsB:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ASP B 647
ARG B 648
TYR B 644
 None
 0.82A 5a7mB-3hhsB:
3.5		 5a7mB-3hhsB:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 486
THR B 541
ARG B 543
 None
 0.74A 5b2sB-3hhsB:
undetectable		 5b2sB-3hhsB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 486
THR B 541
ARG B 543
 None
 0.77A 5b2tB-3hhsB:
undetectable		 5b2tB-3hhsB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 363
ASP B 364
ARG B 359
GLY B 360
 None
 0.95A 5cdnC-3hhsB:
undetectable
5cdnD-3hhsB:
undetectable		 5cdnC-3hhsB:
20.69
5cdnD-3hhsB:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLY B 363
ASP B 364
ARG B 359
GLY B 360
 None
 0.94A 5cdnT-3hhsB:
undetectable
5cdnU-3hhsB:
undetectable		 5cdnT-3hhsB:
20.69
5cdnU-3hhsB:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 HIS A 219
SER A  86
ASN A 369
 CU  A 696 (-3.3A)
None
None
 0.71A 5cprB-3hhsA:
undetectable		 5cprB-3hhsA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 12 LEU A 220
ALA A 226
ILE A 100
ALA A  96
ILE A 231
 None
 1.22A 5eypB-3hhsA:
undetectable		 5eypB-3hhsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ALA B   4
ASN B   7
LEU B   8
 None
 0.26A 5i1nB-3hhsB:
undetectable		 5i1nB-3hhsB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ALA B   4
ASN B   7
LEU B   8
 None
 0.25A 5i1oA-3hhsB:
undetectable		 5i1oA-3hhsB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 ALA B   4
ASN B   7
LEU B   8
 None
 0.40A 5i1pD-3hhsB:
undetectable		 5i1pD-3hhsB:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 7 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
ALA B 396
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.69A 5i3aA-3hhsB:
9.7		 5i3aA-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 7 HIS B 366
HIS B 370
HIS B 209
HIS B 213
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
 0.79A 5i3aA-3hhsB:
9.7		 5i3aA-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 7 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.70A 5i3aA-3hhsA:
7.3		 5i3aA-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 HIS A 368
HIS A 372
HIS A 215
HIS A 219
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
 0.83A 5i3aA-3hhsA:
7.3		 5i3aA-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 7 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
ALA B 396
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.69A 5i3aB-3hhsB:
9.7		 5i3aB-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 7 HIS B 366
HIS B 370
HIS B 209
HIS B 213
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
 0.77A 5i3aB-3hhsB:
9.7		 5i3aB-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 7 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.70A 5i3aB-3hhsA:
7.1		 5i3aB-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 HIS A 368
HIS A 372
HIS A 215
HIS A 219
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
 0.80A 5i3aB-3hhsA:
7.1		 5i3aB-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 7 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
ALA B 396
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.71A 5i3bA-3hhsB:
10.0		 5i3bA-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 7 HIS B 366
HIS B 370
HIS B 209
HIS B 213
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
 0.82A 5i3bA-3hhsB:
10.0		 5i3bA-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 7 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.74A 5i3bA-3hhsA:
7.4		 5i3bA-3hhsA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 209
HIS B 213
HIS B 370
ALA B 396
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.2A)
None
 0.80A 5i3bB-3hhsB:
9.8		 5i3bB-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 370
HIS B 406
HIS B 209
ALA B 396
 CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
CU  B 686 (-3.1A)
None
 0.97A 5i3bB-3hhsB:
9.8		 5i3bB-3hhsB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 VAL A 539
LEU A 595
MET A 534
 None
 0.79A 5ikrA-3hhsA:
undetectable		 5ikrA-3hhsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 PRO A 381
ARG A 305
GLU A 382
 None
 0.97A 5j6hA-3hhsA:
2.0		 5j6hA-3hhsA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 LYS B 275
ASP B 157
ARG B 398
 None
 1.00A 5jwaA-3hhsB:
undetectable
5jwaH-3hhsB:
undetectable		 5jwaA-3hhsB:
21.52
5jwaH-3hhsB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 6 GLU A 171
TYR B  41
TYR B  78
PHE B 465
 None
 1.31A 5lrbA-3hhsA:
undetectable		 5lrbA-3hhsA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_B_ACTB805_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT
ACETONE CARBOXYLASE
BETA SUBUNIT)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 VAL A  58
GLU A  57
LYS A 178
LYS A  27
 None
 1.31A 5m45A-3hhsA:
0.1
5m45B-3hhsA:
0.0		 5m45A-3hhsA:
23.00
5m45B-3hhsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 10 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
 0.69A 5m8nA-3hhsB:
8.6		 5m8nA-3hhsB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 10 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.68A 5m8nA-3hhsA:
5.1		 5m8nA-3hhsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 10 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
 0.70A 5m8nB-3hhsB:
8.7		 5m8nB-3hhsB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 10 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.68A 5m8nB-3hhsA:
5.1		 5m8nB-3hhsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 9 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
 0.67A 5m8nC-3hhsB:
8.6		 5m8nC-3hhsB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 9 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.66A 5m8nC-3hhsA:
4.9		 5m8nC-3hhsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 7 HIS B 213
HIS B 366
ASN B 367
HIS B 370
 CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
 0.67A 5m8rA-3hhsB:
8.3		 5m8rA-3hhsB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 7 HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.63A 5m8rA-3hhsA:
5.1		 5m8rA-3hhsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 HIS B 213
HIS B 366
ASN B 367
HIS B 370
 CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
 0.67A 5m8rB-3hhsB:
8.5		 5m8rB-3hhsB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 8 HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.63A 5m8rB-3hhsA:
4.9		 5m8rB-3hhsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 8 HIS B 213
HIS B 366
ASN B 367
HIS B 370
GLY B 391
 CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.71A 5m8rC-3hhsB:
8.5		 5m8rC-3hhsB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 8 HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.68A 5m8rC-3hhsA:
5.1		 5m8rC-3hhsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 8 HIS B 213
HIS B 366
ASN B 367
HIS B 370
 CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
 0.72A 5m8rD-3hhsB:
8.7		 5m8rD-3hhsB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 8 HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.68A 5m8rD-3hhsA:
5.1		 5m8rD-3hhsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 5 HIS A 408
HIS A 368
HIS A 215
HIS A 245
HIS A 219
 CU  A 697 (-3.1A)
CU  A 697 (-3.2A)
CU  A 696 (-3.2A)
CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
 1.46A 5mhuA-3hhsA:
undetectable		 5mhuA-3hhsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 5 HIS A 408
HIS A 368
HIS A 215
HIS A 245
HIS A 219
 CU  A 697 (-3.1A)
CU  A 697 (-3.2A)
CU  A 696 (-3.2A)
CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
 1.46A 5mhvA-3hhsA:
undetectable		 5mhvA-3hhsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 HIS A 484
ASP A 208
HIS A 593
 None
 0.96A 5n1tW-3hhsA:
2.6		 5n1tW-3hhsA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 TYR B 127
SER B  83
TRP B 210
 None
 0.92A 5n8jB-3hhsB:
undetectable		 5n8jB-3hhsB:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 TYR B 127
SER B  83
TRP B 210
 None
 0.91A 5n8jA-3hhsB:
undetectable		 5n8jA-3hhsB:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 TYR B 127
SER B  83
TRP B 210
 None
 0.89A 5n8jD-3hhsB:
undetectable		 5n8jD-3hhsB:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.57A 5qgjA-3hhsB:
undetectable		 5qgjA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.66A 5qglA-3hhsB:
undetectable		 5qglA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.53A 5qgmA-3hhsB:
undetectable		 5qgmA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.59A 5qgnA-3hhsB:
undetectable		 5qgnA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.63A 5qguA-3hhsB:
undetectable		 5qguA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.65A 5qgvA-3hhsB:
undetectable		 5qgvA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.66A 5qgwA-3hhsB:
undetectable		 5qgwA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.66A 5qgxA-3hhsB:
undetectable		 5qgxA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.65A 5qgyA-3hhsB:
undetectable		 5qgyA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.67A 5qgzA-3hhsB:
undetectable		 5qgzA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.66A 5qh0A-3hhsB:
undetectable		 5qh0A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.65A 5qh1A-3hhsB:
undetectable		 5qh1A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.67A 5qh2A-3hhsB:
undetectable		 5qh2A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.65A 5qh3A-3hhsB:
undetectable		 5qh3A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.63A 5qh4A-3hhsB:
undetectable		 5qh4A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.61A 5qh5A-3hhsB:
undetectable		 5qh5A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.63A 5qh6A-3hhsB:
undetectable		 5qh6A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.63A 5qh7A-3hhsB:
undetectable		 5qh7A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.62A 5qh9A-3hhsB:
undetectable		 5qh9A-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.62A 5qhcA-3hhsB:
undetectable		 5qhcA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.61A 5qheA-3hhsB:
undetectable		 5qheA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.64A 5qhfA-3hhsB:
undetectable		 5qhfA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.60A 5qhgA-3hhsB:
undetectable		 5qhgA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 VAL B 435
VAL B 489
GLN B 533
 None
 0.65A 5qhhA-3hhsB:
undetectable		 5qhhA-3hhsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 8 LEU A 202
ARG A 206
LEU A 485
ILE A 211
 None
 0.93A 5v0vA-3hhsA:
undetectable		 5v0vA-3hhsA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 ALA B 626
VAL B 604
ILE B 606
ILE B 542
GLN B 533
 None
 1.32A 5y80A-3hhsB:
undetectable		 5y80A-3hhsB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.71A 5z0fA-3hhsB:
10.0
5z0fB-3hhsB:
undetectable		 5z0fA-3hhsB:
10.02
5z0fB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.13A 5z0fA-3hhsB:
10.0
5z0fB-3hhsB:
undetectable		 5z0fA-3hhsB:
10.02
5z0fB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.72A 5z0fA-3hhsA:
7.8
5z0fB-3hhsA:
undetectable		 5z0fA-3hhsA:
10.09
5z0fB-3hhsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.70A 5z0gA-3hhsB:
10.0
5z0gB-3hhsB:
undetectable		 5z0gA-3hhsB:
10.02
5z0gB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.10A 5z0gA-3hhsB:
10.0
5z0gB-3hhsB:
undetectable		 5z0gA-3hhsB:
10.02
5z0gB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.72A 5z0gA-3hhsA:
8.0
5z0gB-3hhsA:
undetectable		 5z0gA-3hhsA:
10.09
5z0gB-3hhsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.68A 5z0hA-3hhsB:
10.1
5z0hB-3hhsB:
undetectable		 5z0hA-3hhsB:
10.02
5z0hB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.13A 5z0hA-3hhsB:
10.1
5z0hB-3hhsB:
undetectable		 5z0hA-3hhsB:
10.02
5z0hB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 366
HIS B 239
HIS B 209
VAL B 389
ASP B 399
 CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
CU  B 686 (-3.1A)
None
None
 1.42A 5z0hA-3hhsB:
10.1
5z0hB-3hhsB:
undetectable		 5z0hA-3hhsB:
10.02
5z0hB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.72A 5z0hA-3hhsA:
8.1
5z0hB-3hhsA:
undetectable		 5z0hA-3hhsA:
10.09
5z0hB-3hhsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.69A 5z0iA-3hhsB:
10.1
5z0iB-3hhsB:
undetectable		 5z0iA-3hhsB:
10.02
5z0iB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.10A 5z0iA-3hhsB:
10.1
5z0iB-3hhsB:
undetectable		 5z0iA-3hhsB:
10.02
5z0iB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 366
HIS B 239
HIS B 209
VAL B 389
ASP B 399
 CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
CU  B 686 (-3.1A)
None
None
 1.46A 5z0iA-3hhsB:
10.1
5z0iB-3hhsB:
undetectable		 5z0iA-3hhsB:
10.02
5z0iB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.71A 5z0iA-3hhsA:
8.1
5z0iB-3hhsA:
undetectable		 5z0iA-3hhsA:
10.09
5z0iB-3hhsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.66A 5z0jA-3hhsB:
10.0
5z0jB-3hhsB:
undetectable		 5z0jA-3hhsB:
10.02
5z0jB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.10A 5z0jA-3hhsB:
10.0
5z0jB-3hhsB:
undetectable		 5z0jA-3hhsB:
10.02
5z0jB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.69A 5z0jA-3hhsA:
7.9
5z0jB-3hhsA:
undetectable		 5z0jA-3hhsA:
10.09
5z0jB-3hhsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.65A 5z0kA-3hhsB:
10.0
5z0kB-3hhsB:
undetectable		 5z0kA-3hhsB:
10.02
5z0kB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.00A 5z0kA-3hhsB:
10.0
5z0kB-3hhsB:
undetectable		 5z0kA-3hhsB:
10.02
5z0kB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 366
HIS B 239
HIS B 209
VAL B 389
ASP B 399
 CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
CU  B 686 (-3.1A)
None
None
 1.47A 5z0kA-3hhsB:
10.0
5z0kB-3hhsB:
undetectable		 5z0kA-3hhsB:
10.02
5z0kB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.69A 5z0kA-3hhsA:
8.0
5z0kB-3hhsA:
undetectable		 5z0kA-3hhsA:
10.09
5z0kB-3hhsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.68A 5z0lA-3hhsB:
9.8
5z0lB-3hhsB:
undetectable		 5z0lA-3hhsB:
10.02
5z0lB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 209
HIS B 366
ASN B 367
HIS B 370
PRO B  87
 CU  B 686 (-3.1A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 1.07A 5z0lA-3hhsB:
9.8
5z0lB-3hhsB:
undetectable		 5z0lA-3hhsB:
10.02
5z0lB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 366
HIS B 239
HIS B 209
VAL B 389
ASP B 399
 CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
CU  B 686 (-3.1A)
None
None
 1.44A 5z0lA-3hhsB:
9.8
5z0lB-3hhsB:
undetectable		 5z0lA-3hhsB:
10.02
5z0lB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.73A 5z0lA-3hhsA:
8.0
5z0lB-3hhsA:
undetectable		 5z0lA-3hhsA:
10.09
5z0lB-3hhsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		6 / 11 HIS B 209
HIS B 213
HIS B 366
ASN B 367
HIS B 370
VAL B 371
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.76A 5z0mA-3hhsB:
10.1
5z0mB-3hhsB:
undetectable		 5z0mA-3hhsB:
9.84
5z0mB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 11 HIS B 366
HIS B 239
HIS B 209
VAL B 389
ASP B 399
 CU  B   1 (-3.3A)
CU  B 686 (-3.1A)
CU  B 686 (-3.1A)
None
None
 1.37A 5z0mA-3hhsB:
10.1
5z0mB-3hhsB:
undetectable		 5z0mA-3hhsB:
9.84
5z0mB-3hhsB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		5 / 11 HIS A 215
HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.82A 5z0mA-3hhsA:
8.1
5z0mB-3hhsA:
undetectable		 5z0mA-3hhsA:
10.09
5z0mB-3hhsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		3 / 3 HIS B 366
HIS B 370
HIS B 406
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
 0.23A 5zrdA-3hhsB:
5.6		 5zrdA-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		3 / 3 HIS A 368
HIS A 372
HIS A 408
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
 0.16A 5zrdA-3hhsA:
3.6		 5zrdA-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 209
HIS B 213
PHE B 235
HIS B 239
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
None
CU  B 686 (-3.1A)
 0.77A 5zrdB-3hhsB:
3.5		 5zrdB-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 366
HIS B 370
PHE B 402
HIS B 406
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B   1 ( 4.8A)
CU  B   1 (-3.1A)
 0.25A 5zrdB-3hhsB:
3.5		 5zrdB-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 215
HIS A 219
PHE A 241
HIS A 245
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
None
CU  A 696 (-3.2A)
 0.82A 5zrdB-3hhsA:
5.0		 5zrdB-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 368
HIS A 372
PHE A 404
HIS A 408
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 697 ( 4.9A)
CU  A 697 (-3.1A)
 0.30A 5zrdB-3hhsA:
5.0		 5zrdB-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 209
HIS B 213
HIS B 239
PHE B 402
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B 686 (-3.1A)
CU  B   1 ( 4.8A)
 0.73A 5zrdB-3hhsB:
3.5		 5zrdB-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 366
HIS B 370
HIS B 406
PHE B 235
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
None
 1.02A 5zrdB-3hhsB:
3.5		 5zrdB-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 370
HIS B 406
HIS B 366
PHE B  85
 CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
CU  B   1 (-3.3A)
None
 1.15A 5zrdB-3hhsB:
3.5		 5zrdB-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 215
HIS A 219
HIS A 245
PHE A 404
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 696 (-3.2A)
CU  A 697 ( 4.9A)
 0.77A 5zrdB-3hhsA:
5.0		 5zrdB-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 368
HIS A 372
HIS A 408
PHE A 241
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
None
 1.04A 5zrdB-3hhsA:
5.0		 5zrdB-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 372
HIS A 408
HIS A 368
PHE A  88
 CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
CU  A 697 (-3.2A)
None
 1.21A 5zrdB-3hhsA:
5.0		 5zrdB-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 209
HIS B 213
HIS B 239
PHE B 402
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B 686 (-3.1A)
CU  B   1 ( 4.8A)
 0.81A 5zrdC-3hhsB:
3.2		 5zrdC-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 366
HIS B 370
HIS B 406
PHE B 235
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
None
 1.07A 5zrdC-3hhsB:
3.2		 5zrdC-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 370
HIS B 406
HIS B 366
PHE B  85
 CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
CU  B   1 (-3.3A)
None
 1.18A 5zrdC-3hhsB:
3.2		 5zrdC-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 215
HIS A 219
HIS A 245
PHE A 404
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 696 (-3.2A)
CU  A 697 ( 4.9A)
 0.85A 5zrdC-3hhsA:
3.8		 5zrdC-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 368
HIS A 372
HIS A 408
PHE A 241
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
None
 1.08A 5zrdC-3hhsA:
3.8		 5zrdC-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 372
HIS A 408
HIS A 368
PHE A  88
 CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
CU  A 697 (-3.2A)
None
 1.24A 5zrdC-3hhsA:
3.8		 5zrdC-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 209
HIS B 213
HIS B 239
PHE B 402
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B 686 (-3.1A)
CU  B   1 ( 4.8A)
 0.72A 5zrdD-3hhsB:
2.6		 5zrdD-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 366
HIS B 370
HIS B 406
PHE B 235
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
None
 1.04A 5zrdD-3hhsB:
2.6		 5zrdD-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 5 HIS B 370
HIS B 406
HIS B 366
PHE B  85
 CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
CU  B   1 (-3.3A)
None
 1.14A 5zrdD-3hhsB:
2.6		 5zrdD-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 215
HIS A 219
HIS A 245
PHE A 404
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 696 (-3.2A)
CU  A 697 ( 4.9A)
 0.77A 5zrdD-3hhsA:
3.7		 5zrdD-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 368
HIS A 372
HIS A 408
PHE A 241
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
None
 1.06A 5zrdD-3hhsA:
3.7		 5zrdD-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 3hhs PHENOLOXIDASE
SUBUNIT 2
(Manduca
sexta) 		4 / 5 HIS A 372
HIS A 408
HIS A 368
PHE A  88
 CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
CU  A 697 (-3.2A)
None
 1.20A 5zrdD-3hhsA:
3.7		 5zrdD-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		5 / 12 PHE B 151
LEU B 459
GLY B 460
GLN B 279
ASP B  13
 None
 1.14A 6bxmA-3hhsB:
undetectable		 6bxmA-3hhsB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 ARG B  63
ILE B  62
GLN B 110
ASP B 105
 None
 1.21A 6cbdA-3hhsB:
undetectable		 6cbdA-3hhsB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 SER B 278
ASP B 392
GLN B 386
THR B 150
 None
 1.38A 6djzA-3hhsB:
undetectable		 6djzA-3hhsB:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3hhs PHENOLOXIDASE
SUBUNIT 1
(Manduca
sexta) 		4 / 6 GLU B 418
ARG B 522
LYS B 649
PHE B 518
 None
 1.48A 6fgdA-3hhsB:
undetectable		 6fgdA-3hhsB:
20.00