SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hi0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		4 / 8 MET A 243
SER A 226
ALA A 219
ILE A 218
 None
 0.86A 1gm7A-3hi0A:
undetectable
1gm7B-3hi0A:
undetectable		 1gm7A-3hi0A:
17.61
1gm7B-3hi0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 10 GLY A  51
VAL A  65
ALA A  94
ASN A 100
ALA A  98
 None
 1.06A 1likA-3hi0A:
undetectable		 1likA-3hi0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 9 LEU A 200
LEU A 153
ALA A 276
LEU A 244
PHE A 208
 None
 1.23A 1tbfA-3hi0A:
6.4		 1tbfA-3hi0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 151
PRO A 168
GLY A 147
LEU A 174
GLY A 171
 None
 0.88A 1uakA-3hi0A:
undetectable		 1uakA-3hi0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		4 / 6 ARG A  96
ILE A 105
GLY A 101
ALA A  98
 None
 0.99A 1wpuA-3hi0A:
undetectable		 1wpuA-3hi0A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		4 / 6 ARG A  96
ILE A 105
GLY A 101
ALA A  98
 None
 1.00A 1wpuB-3hi0A:
1.5		 1wpuB-3hi0A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  53
GLY A 171
GLY A 149
GLY A  51
LEU A 151
 None
 0.76A 2oxtA-3hi0A:
undetectable		 2oxtA-3hi0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  53
GLY A 171
GLY A 149
GLY A  51
LEU A 151
 None
 0.81A 2oxtD-3hi0A:
undetectable		 2oxtD-3hi0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  22
LEU A  50
ALA A  95
LEU A  90
VAL A  89
 None
 0.85A 2yqzB-3hi0A:
undetectable		 2yqzB-3hi0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 11 ALA A  91
ILE A 105
ILE A 111
ILE A  19
THR A  92
 None
 1.01A 3clbA-3hi0A:
undetectable		 3clbA-3hi0A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  53
GLY A 171
GLY A 149
GLY A  51
LEU A 151
 None
 0.94A 3eluA-3hi0A:
undetectable		 3eluA-3hi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  53
GLY A 171
GLY A 149
GLY A  51
LEU A 151
 None
 0.94A 3elwA-3hi0A:
undetectable		 3elwA-3hi0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  53
GLY A 171
GLY A 149
GLY A  51
LEU A 151
 None
 0.99A 3embA-3hi0A:
undetectable		 3embA-3hi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  53
GLY A 171
GLY A 149
GLY A  51
LEU A 151
 None
 0.94A 3gczA-3hi0A:
undetectable		 3gczA-3hi0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  53
GLY A 171
GLY A 149
GLY A  51
LEU A 169
 None
 0.97A 3gczA-3hi0A:
undetectable		 3gczA-3hi0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 387
ALA A 368
LEU A 367
LEU A 317
GLY A 440
 None
 1.10A 3ozwB-3hi0A:
undetectable		 3ozwB-3hi0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 10 ASP A 145
GLN A 234
PHE A 293
GLY A 235
GLY A 212
 None
 1.30A 3v3oD-3hi0A:
undetectable		 3v3oD-3hi0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		4 / 5 LEU A 307
ARG A  36
PRO A 316
ALA A  37
 None
None
None
MPD  A 508 ( 4.8A)
 1.48A 3vm4A-3hi0A:
undetectable		 3vm4A-3hi0A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		4 / 6 GLY A 439
ALA A 406
TYR A 409
GLU A 433
 None
 0.97A 4ae1A-3hi0A:
undetectable		 4ae1A-3hi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		4 / 4 GLY A 144
LEU A 247
PHE A 246
ILE A 218
 None
 0.86A 4xv2A-3hi0A:
undetectable		 4xv2A-3hi0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 10 LEU A  54
GLU A 176
LEU A 172
GLY A  22
LEU A  50
 None
 1.42A 5dxbA-3hi0A:
undetectable		 5dxbA-3hi0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 9 LEU A 153
ILE A 165
GLY A 164
GLY A 162
LEU A 200
 None
 0.94A 5o96A-3hi0A:
undetectable
5o96B-3hi0A:
undetectable		 5o96A-3hi0A:
18.90
5o96B-3hi0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3hi0 PUTATIVE
EXOPOLYPHOSPHATASE
(Agrobacterium
fabrum) 		5 / 7 GLY A 213
GLY A 212
GLY A 147
GLY A 149
GLY A 170
 None
 1.04A 6ag0A-3hi0A:
undetectable		 6ag0A-3hi0A:
11.26