SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hib PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 10 PHE A1934
LEU A1930
VAL A1926
PHE A1889
VAL A1954
 None
 1.27A 1q23K-3hibA:
undetectable		 1q23K-3hibA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hib PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A1934
LEU A1930
VAL A1926
PHE A1889
VAL A1954
 None
 1.27A 1q23L-3hibA:
undetectable		 1q23L-3hibA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3hib PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 8 PHE A1889
LEU A1983
LEU A1979
ALA A1886
 None
 0.85A 2vcvP-3hibA:
undetectable		 2vcvP-3hibA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 3hib PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 9 ILE A2019
ARG A2027
ALA A2042
VAL A2045
 None
 1.03A 2vufB-3hibA:
1.8		 2vufB-3hibA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3hib PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A1858
SER A1859
THR A1862
 None
 0.28A 4luhA-3hibA:
2.8		 4luhA-3hibA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3hib PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A1926
PHE A1943
ARG A1895
 None
 0.95A 4xr4B-3hibA:
undetectable		 4xr4B-3hibA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hib PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1995
ILE A1997
PHE A2000
 None
 0.62A 5kirA-3hibA:
undetectable		 5kirA-3hibA:
21.10