SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 GLY A  59
LEU A  53
ILE A  56
ILE A  66
LEU A  98
 None
 1.21A 1kyvA-3hidA:
undetectable
1kyvE-3hidA:
undetectable		 1kyvA-3hidA:
15.81
1kyvE-3hidA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 GLY A  59
SER A  58
LEU A  53
ILE A  56
LEU A  98
 None
 1.18A 1kyvA-3hidA:
undetectable
1kyvE-3hidA:
undetectable		 1kyvA-3hidA:
15.81
1kyvE-3hidA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 LEU A  98
GLY A  59
SER A  58
LEU A  53
ILE A  56
 None
 1.19A 1kyvB-3hidA:
2.7
1kyvC-3hidA:
2.7		 1kyvB-3hidA:
15.81
1kyvC-3hidA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 LEU A  98
GLY A  59
SER A  58
LEU A  53
ILE A  56
 None
 1.16A 1kyvC-3hidA:
2.6
1kyvD-3hidA:
2.7		 1kyvC-3hidA:
15.81
1kyvD-3hidA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 ILE A  66
LEU A  98
GLY A  59
LEU A  53
ILE A  56
 None
 1.19A 1kyvD-3hidA:
2.7
1kyvE-3hidA:
undetectable		 1kyvD-3hidA:
15.81
1kyvE-3hidA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 LEU A  98
GLY A  59
SER A  58
LEU A  53
ILE A  56
 None
 1.14A 1kyvD-3hidA:
2.7
1kyvE-3hidA:
undetectable		 1kyvD-3hidA:
15.81
1kyvE-3hidA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		3 / 3 LEU A 406
LEU A 311
MET A 376
 None
 0.63A 1ya3B-3hidA:
undetectable		 1ya3B-3hidA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 GLY A 252
SER A 253
GLY A  70
ASP A 232
ILE A 231
 None
 1.14A 2b25B-3hidA:
2.2		 2b25B-3hidA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 9 TYR A 399
VAL A 267
THR A  10
ILE A 313
VAL A 316
 None
 1.41A 2l8mA-3hidA:
undetectable		 2l8mA-3hidA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		6 / 12 ILE A  56
ILE A  69
LEU A  80
VAL A  73
VAL A 149
ILE A 197
 None
 1.23A 2nnhA-3hidA:
undetectable		 2nnhA-3hidA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 ILE A  69
LEU A  80
VAL A  73
VAL A 149
ILE A 197
 None
 1.00A 2vn0A-3hidA:
undetectable		 2vn0A-3hidA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 5 VAL A 403
VAL A 316
ASP A 312
SER A 271
 None
 1.11A 2x45A-3hidA:
undetectable		 2x45A-3hidA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 5 VAL A 403
VAL A 316
ASP A 312
SER A 271
 None
 1.07A 2x45C-3hidA:
undetectable		 2x45C-3hidA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 SER A  67
PRO A  57
LEU A 255
VAL A 249
TYR A  34
 None
 0.94A 2zifB-3hidA:
undetectable		 2zifB-3hidA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 7 LEU A  23
LEU A 325
VAL A   7
LEU A 311
 None
 0.88A 3g8iA-3hidA:
undetectable		 3g8iA-3hidA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		3 / 3 SER A 206
GLY A 254
SER A 101
 None
 0.64A 3loqA-3hidA:
undetectable		 3loqA-3hidA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 6 ILE A 313
LEU A 311
ARG A 318
THR A 227
 None
 1.13A 3wg7A-3hidA:
undetectable
3wg7J-3hidA:
undetectable		 3wg7A-3hidA:
22.51
3wg7J-3hidA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 5 THR A 157
ILE A 160
LYS A 161
GLU A 164
 None
 0.62A 4ac9C-3hidA:
5.2		 4ac9C-3hidA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 5 THR A 157
ILE A 160
LYS A 161
GLU A 164
 None
 0.60A 4acaC-3hidA:
5.6		 4acaC-3hidA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 5 THR A 157
ILE A 160
LYS A 161
GLU A 164
 None
 0.70A 4acbC-3hidA:
5.7		 4acbC-3hidA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 8 GLY A 234
ARG A 318
ILE A 322
THR A 245
 None
 0.71A 4em2A-3hidA:
undetectable		 4em2A-3hidA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 8 GLY A 288
TYR A 399
LEU A 336
VAL A 335
 None
 0.94A 4fgzA-3hidA:
undetectable		 4fgzA-3hidA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		3 / 3 HIS A 169
GLY A 146
ILE A 165
 None
 0.54A 4k50A-3hidA:
undetectable		 4k50A-3hidA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		3 / 3 HIS A 169
GLY A 146
ILE A 165
 None
 0.53A 4k50I-3hidA:
undetectable		 4k50I-3hidA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 7 VAL A  31
ALA A  28
PHE A 430
TYR A 262
 None
 1.02A 4lb2A-3hidA:
2.2		 4lb2A-3hidA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		3 / 3 ASP A 421
VAL A  20
ASN A  47
 None
 0.78A 4lmnA-3hidA:
undetectable		 4lmnA-3hidA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 ASN A  39
ALA A 137
GLY A 135
SER A 241
GLY A 146
 None
 1.15A 4obwA-3hidA:
2.2		 4obwA-3hidA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 6 ILE A 134
GLN A 225
ILE A 231
ASP A 230
 None
 1.19A 4w5tA-3hidA:
undetectable		 4w5tA-3hidA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		6 / 12 GLY A  37
GLY A  70
GLY A  36
GLU A 222
VAL A 205
ILE A  68
 None
 1.47A 5e9qC-3hidA:
undetectable		 5e9qC-3hidA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		6 / 12 GLY A  37
GLY A  70
GLY A  36
GLU A 222
VAL A 205
ILE A  68
 None
 1.49A 5eiwC-3hidA:
undetectable		 5eiwC-3hidA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 VAL A 403
GLU A 404
THR A 227
ARG A 318
LEU A 325
 None
 1.26A 5ogcB-3hidA:
undetectable		 5ogcB-3hidA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 10 PHE A 290
LEU A 291
GLY A 288
ILE A 400
LEU A 397
 None
 1.25A 5oy01-3hidA:
undetectable
5oy07-3hidA:
undetectable		 5oy01-3hidA:
13.37
5oy07-3hidA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		3 / 3 ARG A 307
PRO A 280
TYR A 238
 None
 0.97A 5tzoB-3hidA:
undetectable		 5tzoB-3hidA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 5 LEU A 336
LYS A 332
LEU A 291
GLU A 297
 None
 1.26A 5weaA-3hidA:
undetectable		 5weaA-3hidA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 VAL A 342
TRP A 379
LEU A 333
ILE A 400
ALA A 396
 None
 1.21A 5xprA-3hidA:
undetectable		 5xprA-3hidA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 7 VAL A   5
VAL A   7
ILE A 413
ASP A 412
 None
 0.84A 5yf9B-3hidA:
undetectable		 5yf9B-3hidA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		5 / 12 VAL A 263
VAL A 260
GLY A  72
VAL A  73
PRO A  57
 None
 1.08A 6brdC-3hidA:
undetectable		 6brdC-3hidA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 6 ILE A 134
GLN A 225
ILE A 231
ASP A 230
 None
 1.14A 6cbdA-3hidA:
undetectable		 6cbdA-3hidA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3hid ADENYLOSUCCINATE
SYNTHETASE
(Yersinia
pestis) 		4 / 8 TYR A 399
THR A 331
TYR A 270
TRP A 379
 None
 1.40A 6cnjD-3hidA:
undetectable
6cnjE-3hidA:
3.0		 6cnjD-3hidA:
11.11
6cnjE-3hidA:
13.81