SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 11 LEU A  75
ALA A  97
GLU A  96
MET A 125
ILE A 101
 None
 1.01A 1g50A-3higA:
undetectable		 1g50A-3higA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		9 / 10 TYR A 359
THR A 457
ASN A 460
ASP A 462
TYR A 463
VAL A 485
HIS A 510
HIS A 512
HIS A 675
 None
TPQ  A 461 ( 3.7A)
TPQ  A 461 ( 3.3A)
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.5A)
TPQ  A 461 ( 4.1A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.45A 1ivvA-3higA:
38.7		 1ivvA-3higA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		7 / 10 THR A 457
ASN A 460
ASP A 462
TYR A 463
VAL A 485
HIS A 675
HIS A 512
 TPQ  A 461 ( 3.7A)
TPQ  A 461 ( 3.3A)
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.5A)
TPQ  A 461 ( 4.1A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
 1.47A 1ivvB-3higA:
38.7		 1ivvB-3higA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		9 / 10 TYR A 359
THR A 457
ASN A 460
ASP A 462
TYR A 463
VAL A 485
HIS A 510
HIS A 512
HIS A 675
 None
TPQ  A 461 ( 3.7A)
TPQ  A 461 ( 3.3A)
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.5A)
TPQ  A 461 ( 4.1A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.45A 1ivvB-3higA:
38.7		 1ivvB-3higA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 5 GLU A 393
ARG A 453
LYS A 478
ASP A 466
 None
 1.27A 1k4tA-3higA:
undetectable		 1k4tA-3higA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 8 GLY A 375
TYR A 638
GLU A 113
ARG A  98
 None
 0.91A 1mrjA-3higA:
undetectable		 1mrjA-3higA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 486
HIS A 512
HIS A 510
HIS A 675
 None
CU  A 801 (-3.2A)
CU  A 801 (-3.3A)
CU  A 801 (-3.0A)
 1.08A 1os2A-3higA:
undetectable		 1os2A-3higA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.18A 1rjoA-3higA:
38.5		 1rjoA-3higA:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.17A 1rkyA-3higA:
42.3		 1rkyA-3higA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 5 GLU A 393
ARG A 453
LYS A 478
ASP A 466
 None
 1.29A 1rrjA-3higA:
undetectable		 1rrjA-3higA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 11 LEU A 334
LEU A 328
LEU A 418
LEU A 398
THR A 454
 None
 1.27A 1tz8A-3higA:
undetectable
1tz8B-3higA:
undetectable		 1tz8A-3higA:
12.64
1tz8B-3higA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.47A 1v54A-3higA:
undetectable		 1v54A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.48A 1v54N-3higA:
undetectable		 1v54N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.47A 1v55A-3higA:
undetectable		 1v55A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.51A 1v55N-3higA:
undetectable		 1v55N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.25A 1w2zA-3higA:
44.3		 1w2zA-3higA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.21A 1w2zB-3higA:
44.3		 1w2zB-3higA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.21A 1w2zC-3higA:
44.4		 1w2zC-3higA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.20A 1w2zD-3higA:
44.7		 1w2zD-3higA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 THR A 369
GLU A 218
HIS A 362
 None
 0.92A 1xwfA-3higA:
undetectable		 1xwfA-3higA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 THR A 369
GLU A 218
HIS A 362
 None
 0.90A 1xwfB-3higA:
undetectable		 1xwfB-3higA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 THR A 369
GLU A 218
HIS A 362
 None
 0.87A 1xwfD-3higA:
undetectable		 1xwfD-3higA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 8 HIS A 510
GLY A 507
PHE A 673
ASN A 460
 CU  A 801 (-3.3A)
None
None
TPQ  A 461 ( 3.3A)
 0.78A 2a8tB-3higA:
undetectable		 2a8tB-3higA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.45A 2dyrA-3higA:
undetectable		 2dyrA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 2dyrN-3higA:
undetectable		 2dyrN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.44A 2dysA-3higA:
undetectable		 2dysA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.44A 2dysN-3higA:
undetectable		 2dysN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.45A 2eijA-3higA:
undetectable		 2eijA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 2eijN-3higA:
undetectable		 2eijN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.44A 2eikA-3higA:
undetectable		 2eikA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.51A 2eikN-3higA:
undetectable		 2eikN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.44A 2eilA-3higA:
undetectable		 2eilA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 2eilN-3higA:
undetectable		 2eilN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 2eimA-3higA:
undetectable		 2eimA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.50A 2eimN-3higA:
undetectable		 2eimN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.40A 2einA-3higA:
undetectable		 2einA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.54A 2einN-3higA:
undetectable		 2einN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 PRO A 308
LEU A 312
ARG A 309
GLY A 320
 None
 1.24A 2hs2B-3higA:
undetectable		 2hs2B-3higA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.18A 2oqeA-3higA:
41.6		 2oqeA-3higA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.18A 2oqeB-3higA:
41.2		 2oqeB-3higA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.15A 2oqeC-3higA:
41.6		 2oqeC-3higA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.17A 2oqeD-3higA:
41.2		 2oqeD-3higA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.16A 2oqeF-3higA:
41.0		 2oqeF-3higA:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		6 / 7 ALA A 357
TYR A 359
TYR A 371
ASP A 373
TYR A 463
HIS A 512
 TPQ  A 461 ( 4.9A)
None
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
TPQ  A 461 ( 4.5A)
CU  A 801 (-3.2A)
 0.68A 2pncA-3higA:
46.1		 2pncA-3higA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 6 ALA A 357
TYR A 371
ASP A 373
TYR A 463
HIS A 512
 TPQ  A 461 ( 4.9A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
TPQ  A 461 ( 4.5A)
CU  A 801 (-3.2A)
 0.66A 2pncB-3higA:
50.4		 2pncB-3higA:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 HIS A 340
ARG A 345
PHE A 701
GLN A 583
 None
 1.40A 2qqtA-3higA:
undetectable		 2qqtA-3higA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 7 GLY A 333
VAL A 352
ASP A 466
LEU A 452
ARG A 453
 None
 1.37A 2uyqA-3higA:
undetectable		 2uyqA-3higA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.17A 2w0qA-3higA:
38.7		 2w0qA-3higA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.18A 2w0qB-3higA:
40.7		 2w0qB-3higA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 2y69A-3higA:
undetectable		 2y69A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.58A 2y69N-3higA:
undetectable		 2y69N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 10 THR A 488
ILE A 506
GLY A 507
GLY A 361
THR A 363
 None
 1.34A 2y7wB-3higA:
undetectable		 2y7wB-3higA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 2zxwA-3higA:
undetectable		 2zxwA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 2zxwN-3higA:
undetectable		 2zxwN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 3abkA-3higA:
undetectable		 3abkA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.55A 3abkN-3higA:
undetectable		 3abkN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 3ablA-3higA:
undetectable		 3ablA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 3ablN-3higA:
undetectable		 3ablN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 3abmA-3higA:
undetectable		 3abmA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 3abmN-3higA:
undetectable		 3abmN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.54A 3ag1A-3higA:
undetectable		 3ag1A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.58A 3ag1N-3higA:
undetectable		 3ag1N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.51A 3ag2A-3higA:
undetectable		 3ag2A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 3ag2N-3higA:
undetectable		 3ag2N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 3ag3A-3higA:
undetectable		 3ag3A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.55A 3ag3N-3higA:
undetectable		 3ag3N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.61A 3ag4A-3higA:
undetectable		 3ag4A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.60A 3ag4N-3higA:
undetectable		 3ag4N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 3asnA-3higA:
undetectable		 3asnA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.55A 3asnN-3higA:
undetectable		 3asnN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.51A 3asoA-3higA:
undetectable		 3asoA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 3asoN-3higA:
undetectable		 3asoN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.66A 3bvdA-3higA:
undetectable		 3bvdA-3higA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.56A 3dtuA-3higA:
undetectable		 3dtuA-3higA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.57A 3dtuC-3higA:
undetectable		 3dtuC-3higA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 SER A 456
THR A 382
GLY A 379
LEU A 334
VAL A 514
 None
 1.28A 3fzgA-3higA:
undetectable		 3fzgA-3higA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 708
ASP A 705
LEU A 427
LEU A 445
GLY A 444
 None
 1.27A 3g1uB-3higA:
undetectable		 3g1uB-3higA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 708
ASP A 705
LEU A 427
LEU A 445
GLY A 444
 None
 1.23A 3g1uD-3higA:
undetectable		 3g1uD-3higA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 MET A 421
VAL A 449
LEU A 318
ILE A 468
 None
 0.87A 3gcsA-3higA:
undetectable		 3gcsA-3higA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 708
ASP A 705
LEU A 427
LEU A 445
GLY A 444
 None
 1.28A 3glqA-3higA:
undetectable		 3glqA-3higA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 708
ASP A 705
LEU A 427
LEU A 445
GLY A 444
 None
 1.28A 3glqB-3higA:
undetectable		 3glqB-3higA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.07A 3hiiA-3higA:
67.6		 3hiiA-3higA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		12 / 12 TYR A 148
THR A 185
ASP A 186
TYR A 371
ASP A 373
TRP A 376
GLY A 377
SER A 380
VAL A 381
TYR A 404
TYR A 459
ASN A 460
 BRN  A 901 (-3.7A)
BRN  A 901 ( 4.2A)
BRN  A 901 (-3.9A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.5A)
None
None
None
None
BRN  A 901 (-3.2A)
TPQ  A 461 ( 3.3A)
 0.38A 3hiiA-3higA:
67.6		 3hiiA-3higA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		6 / 12 TYR A 148
THR A 185
ASP A 373
GLY A 375
TYR A 459
ASN A 460
 BRN  A 901 (-3.7A)
BRN  A 901 ( 4.2A)
BRN  A 901 (-3.3A)
None
BRN  A 901 (-3.2A)
TPQ  A 461 ( 3.3A)
 1.42A 3hiiA-3higA:
67.6		 3hiiA-3higA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.06A 3hiiB-3higA:
62.8		 3hiiB-3higA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		12 / 12 TYR A 148
THR A 185
ASP A 186
TYR A 371
ASP A 373
TRP A 376
GLY A 377
SER A 380
VAL A 381
TYR A 404
TYR A 459
ASN A 460
 BRN  A 901 (-3.7A)
BRN  A 901 ( 4.2A)
BRN  A 901 (-3.9A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.5A)
None
None
None
None
BRN  A 901 (-3.2A)
TPQ  A 461 ( 3.3A)
 0.36A 3hiiB-3higA:
62.8		 3hiiB-3higA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		6 / 12 TYR A 148
THR A 185
ASP A 373
GLY A 375
TYR A 459
ASN A 460
 BRN  A 901 (-3.7A)
BRN  A 901 ( 4.2A)
BRN  A 901 (-3.3A)
None
BRN  A 901 (-3.2A)
TPQ  A 461 ( 3.3A)
 1.45A 3hiiB-3higA:
62.8		 3hiiB-3higA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 GLY A 498
ASN A 508
ILE A 506
GLY A 240
GLY A 361
 None
 1.00A 3hs6B-3higA:
undetectable		 3hs6B-3higA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 486
HIS A 512
HIS A 510
HIS A 675
 None
CU  A 801 (-3.2A)
CU  A 801 (-3.3A)
CU  A 801 (-3.0A)
 0.98A 3likA-3higA:
undetectable		 3likA-3higA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 486
HIS A 512
HIS A 510
HIS A 675
 None
CU  A 801 (-3.2A)
CU  A 801 (-3.3A)
CU  A 801 (-3.0A)
 1.00A 3lkaA-3higA:
undetectable		 3lkaA-3higA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 708
ASP A 705
LEU A 427
LEU A 445
GLY A 444
 None
 1.27A 3n58A-3higA:
undetectable		 3n58A-3higA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 11 VAL A 207
GLY A 216
TYR A 238
ASN A 239
ILE A 202
 None
 1.45A 3owxA-3higA:
undetectable
3owxB-3higA:
undetectable		 3owxA-3higA:
15.94
3owxB-3higA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.60A 3s33A-3higA:
undetectable		 3s33A-3higA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.62A 3s38A-3higA:
undetectable		 3s38A-3higA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.56A 3s39A-3higA:
undetectable		 3s39A-3higA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.65A 3s3aA-3higA:
undetectable		 3s3aA-3higA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.60A 3s3bA-3higA:
undetectable		 3s3bA-3higA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.62A 3s3cA-3higA:
undetectable		 3s3cA-3higA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.55A 3s3dA-3higA:
undetectable		 3s3dA-3higA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 7 THR A 491
GLY A 494
GLY A 366
THR A 369
 None
 0.74A 3tajA-3higA:
undetectable		 3tajA-3higA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.48A 3wg7A-3higA:
undetectable		 3wg7A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.50A 3wg7N-3higA:
undetectable		 3wg7N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.50A 3x2qA-3higA:
undetectable		 3x2qA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 3x2qN-3higA:
undetectable		 3x2qN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 11 ILE A 202
ALA A 365
GLY A 366
GLY A 191
LYS A 370
 None
 1.24A 4e47C-3higA:
undetectable		 4e47C-3higA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 8 GLY A 524
PHE A 701
ILE A 346
PHE A 702
 None
 0.93A 4fglD-3higA:
undetectable		 4fglD-3higA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 7 GLY A 524
PHE A 701
ILE A 346
PHE A 702
 None
 0.89A 4fglC-3higA:
undetectable		 4fglC-3higA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 515
SER A 634
LEU A  71
LEU A 378
GLY A 333
 None
 1.39A 4foxC-3higA:
undetectable		 4foxC-3higA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 LEU A  75
ALA A  97
GLU A  96
MET A 125
ILE A 101
 None
 0.88A 4j24D-3higA:
undetectable		 4j24D-3higA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 ILE A 202
ALA A 365
GLY A 366
GLY A 191
LYS A 370
 None
 1.24A 4jlgA-3higA:
undetectable		 4jlgA-3higA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 285
GLY A 209
PHE A 211
ASP A 462
GLY A 483
 None
None
None
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.4A)
 1.00A 4lxzA-3higA:
undetectable		 4lxzA-3higA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 285
GLY A 209
PHE A 211
ASP A 462
GLY A 483
 None
None
None
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.4A)
 1.01A 4lxzC-3higA:
undetectable		 4lxzC-3higA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 7 THR A 625
TRP A 668
TRP A 617
LEU A 654
 None
 1.44A 4nsbA-3higA:
undetectable		 4nsbA-3higA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 ASP A 664
ASP A 519
ASN A 338
 CA  A 802 (-3.2A)
CA  A 802 (-3.2A)
None
 0.56A 4q5mA-3higA:
undetectable		 4q5mA-3higA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 285
GLY A 209
PHE A 211
ASP A 462
GLY A 483
 None
None
None
TPQ  A 461 ( 3.9A)
TPQ  A 461 ( 4.4A)
 0.91A 4qa0A-3higA:
undetectable		 4qa0A-3higA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 GLY A 524
PHE A 701
ILE A 346
PHE A 702
 None
 0.80A 4qogA-3higA:
undetectable
4qogB-3higA:
undetectable		 4qogA-3higA:
15.94
4qogB-3higA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 11 ILE A 202
ALA A 365
GLY A 366
GLY A 191
LYS A 370
 None
 1.25A 5ayfA-3higA:
undetectable		 5ayfA-3higA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 5b1aA-3higA:
undetectable		 5b1aA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 5b1aN-3higA:
undetectable		 5b1aN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.51A 5b1bA-3higA:
undetectable		 5b1bA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 5b1bN-3higA:
undetectable		 5b1bN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 5b3sA-3higA:
undetectable		 5b3sA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.51A 5b3sN-3higA:
undetectable		 5b3sN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 LYS A 462
ASP A 466
TYR A 463
LEU A 378
 TPQ  A 461 ( 3.4A)
None
TPQ  A 461 ( 4.5A)
None
 1.32A 5bmvB-3higA:
undetectable		 5bmvB-3higA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 TYR A 627
LYS A  79
ARG A 517
LEU A 632
 None
CA  A 802 (-3.6A)
None
None
 1.25A 5bphA-3higA:
undetectable		 5bphA-3higA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 12 LEU A  75
ALA A  97
GLU A  96
MET A 125
ILE A 101
 None
 0.85A 5gtrA-3higA:
undetectable		 5gtrA-3higA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 5iy5A-3higA:
undetectable		 5iy5A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 5iy5N-3higA:
undetectable		 5iy5N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 11 ALA A 487
ALA A 365
GLY A 366
THR A 369
LEU A 674
 None
 1.13A 5lf7H-3higA:
undetectable
5lf7I-3higA:
undetectable		 5lf7H-3higA:
15.88
5lf7I-3higA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 PHE A 310
LEU A 318
ARG A 309
GLY A 320
 None
 1.10A 5o4yA-3higA:
undetectable		 5o4yA-3higA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.60A 5w97a-3higA:
undetectable		 5w97a-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.57A 5waua-3higA:
undetectable		 5waua-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 5x19A-3higA:
undetectable		 5x19A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.56A 5x19N-3higA:
undetectable		 5x19N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.54A 5x1bA-3higA:
undetectable		 5x1bA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.55A 5x1bN-3higA:
undetectable		 5x1bN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.57A 5x1fA-3higA:
undetectable		 5x1fA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.56A 5x1fN-3higA:
undetectable		 5x1fN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 5xdqA-3higA:
undetectable		 5xdqA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.56A 5xdqN-3higA:
undetectable		 5xdqN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.54A 5xdxA-3higA:
undetectable		 5xdxA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.55A 5xdxN-3higA:
undetectable		 5xdxN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 6 TYR A 463
LEU A 358
GLU A 354
LEU A 372
 TPQ  A 461 ( 4.5A)
None
None
None
 1.35A 5xooA-3higA:
undetectable		 5xooA-3higA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		4 / 7 GLY A 507
GLY A 498
ASN A 684
THR A 685
 None
None
None
TPQ  A 461 ( 2.4A)
 0.78A 5ybbB-3higA:
undetectable		 5ybbB-3higA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 5z84A-3higA:
undetectable		 5z84A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 5z84N-3higA:
undetectable		 5z84N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.52A 5z85A-3higA:
undetectable		 5z85A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.50A 5z85N-3higA:
undetectable		 5z85N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.51A 5z86A-3higA:
undetectable		 5z86A-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.57A 5z86N-3higA:
undetectable		 5z86N-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.51A 5zcoA-3higA:
undetectable		 5zcoA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.48A 5zcoN-3higA:
undetectable		 5zcoN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 5zcpA-3higA:
undetectable		 5zcpA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 5zcpN-3higA:
undetectable		 5zcpN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.48A 5zcqA-3higA:
undetectable		 5zcqA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.49A 5zcqN-3higA:
undetectable		 5zcqN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		5 / 10 LEU A  75
ALA A  97
GLU A  96
MET A 125
ILE A 101
 None
 0.91A 6cbzB-3higA:
undetectable		 6cbzB-3higA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 480
ARG A 453
ILE A 464
 None
 0.74A 6fgdA-3higA:
undetectable		 6fgdA-3higA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.63A 6hu9a-3higA:
undetectable		 6hu9a-3higA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.62A 6hu9m-3higA:
undetectable		 6hu9m-3higA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.50A 6nknA-3higA:
undetectable		 6nknA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.53A 6nknN-3higA:
undetectable		 6nknN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.54A 6nmfA-3higA:
undetectable		 6nmfA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.60A 6nmfN-3higA:
undetectable		 6nmfN-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.59A 6nmpA-3higA:
undetectable		 6nmpA-3higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens) 		3 / 3 HIS A 675
HIS A 510
HIS A 512
 CU  A 801 (-3.0A)
CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
 0.60A 6nmpN-3higA:
undetectable		 6nmpN-3higA:
20.94