SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3him'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3him PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 10 GLY A 169
VAL A 172
THR A 166
VAL A 101
HIS A  72
 None
 1.28A 1v3qE-3himA:
undetectable		 1v3qE-3himA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3him PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 4 LEU A  63
LEU A  69
SER A  68
LEU A 121
 None
 1.15A 1ya3A-3himA:
undetectable		 1ya3A-3himA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 3him PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		6 / 12 GLY A 147
ALA A  89
ASP A  91
ILE A  87
VAL A 139
ILE A 143
 None
 1.47A 2f8gB-3himA:
undetectable		 2f8gB-3himA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 3him PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 8 ARG A 174
TYR A 181
TRP A 175
THR A 180
 None
 1.18A 2vxaF-3himA:
undetectable
2vxaG-3himA:
undetectable
2vxaI-3himA:
undetectable		 2vxaF-3himA:
17.79
2vxaG-3himA:
17.79
2vxaI-3himA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3him PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 6 ALA A 109
GLY A  33
THR A  37
ILE A  42
 None
 0.84A 6f8cA-3himA:
undetectable		 6f8cA-3himA:
17.62