SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hiq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 TYR A  16
LEU A  20
LEU A  23
ILE A 181
LEU A   6
 None
 1.25A 1tw4B-3hiqA:
undetectable		 1tw4B-3hiqA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 8 LEU A 144
SER A 147
THR A 149
ALA A  58
 None
 0.95A 3ax9A-3hiqA:
undetectable		 3ax9A-3hiqA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 8 LEU A 144
THR A 149
VAL A 151
ALA A  58
 None
 0.80A 3ax9A-3hiqA:
undetectable		 3ax9A-3hiqA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 PHE A 253
LEU A 205
VAL A 242
ALA A 215
PHE A 224
 None
 1.23A 3nuvA-3hiqA:
undetectable		 3nuvA-3hiqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.13A 3tbgA-3hiqA:
undetectable		 3tbgA-3hiqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.09A 3tbgB-3hiqA:
undetectable		 3tbgB-3hiqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.13A 3tbgC-3hiqA:
undetectable		 3tbgC-3hiqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.12A 3tbgD-3hiqA:
undetectable		 3tbgD-3hiqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		3 / 3 MET A 171
GLN A  22
TYR A   4
 None
 0.71A 4udcA-3hiqA:
undetectable		 4udcA-3hiqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		3 / 3 GLU A 174
ALA A 175
PHE A 178
 None
 0.63A 4v1fA-3hiqA:
undetectable		 4v1fA-3hiqA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		3 / 3 GLU A 174
ALA A 175
PHE A 178
 None
 0.60A 4v1fC-3hiqA:
undetectable		 4v1fC-3hiqA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A  20
PHE A  19
LEU A  65
VAL A  74
TYR A 123
 None
 1.38A 5i8fA-3hiqA:
undetectable		 5i8fA-3hiqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 6 TYR A 180
TRP A 240
LEU A 230
LEU A 212
 None
 1.24A 5xooA-3hiqA:
undetectable		 5xooA-3hiqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 3hiq VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 6 VAL A  74
TYR A 123
GLU A 174
ARG A 177
 None
 0.37A 5z3jA-3hiqA:
28.4		 5z3jA-3hiqA:
28.86