SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 7 ARG A  53
PHE A 105
VAL A  63
ALA A 108
 None
 1.08A 1fo4B-3hiwA:
undetectable		 1fo4B-3hiwA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 TYR A  16
LEU A  20
LEU A  23
ILE A 181
LEU A   6
 None
 1.23A 1tw4B-3hiwA:
undetectable		 1tw4B-3hiwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 7 PRO A 199
LEU A 139
GLY A 140
LEU A 184
 None
 0.91A 1ya4B-3hiwA:
undetectable		 1ya4B-3hiwA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 8 LEU A  65
ILE A 126
TYR A 119
PHE A  91
 None
None
None
C2X  A 260 ( 4.6A)
 0.99A 2weyB-3hiwA:
undetectable		 2weyB-3hiwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 8 LEU A 144
SER A 147
THR A 149
VAL A 151
ALA A  58
 None
 1.03A 3ax9A-3hiwA:
undetectable		 3ax9A-3hiwA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 10 ILE A 126
LEU A  65
VAL A  67
VAL A  54
LEU A  56
 None
 1.04A 3gwxA-3hiwA:
undetectable		 3gwxA-3hiwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 PHE A 253
LEU A 205
VAL A 242
ALA A 215
PHE A 224
 None
 1.21A 3nuvA-3hiwA:
undetectable		 3nuvA-3hiwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.12A 3tbgA-3hiwA:
undetectable		 3tbgA-3hiwA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.09A 3tbgB-3hiwA:
undetectable		 3tbgB-3hiwA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.12A 3tbgC-3hiwA:
undetectable		 3tbgC-3hiwA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 12 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.11A 3tbgD-3hiwA:
undetectable		 3tbgD-3hiwA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 9 LEU A 144
SER A 147
THR A 149
VAL A 151
ALA A  58
 None
 1.06A 3uncA-3hiwA:
undetectable		 3uncA-3hiwA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		3 / 3 MET A 171
GLN A  22
TYR A   4
 None
 0.75A 4udcA-3hiwA:
undetectable		 4udcA-3hiwA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		3 / 3 GLU A 174
ALA A 175
PHE A 178
 C2X  A 260 (-3.0A)
None
None
 0.62A 4v1fA-3hiwA:
undetectable		 4v1fA-3hiwA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		3 / 3 GLU A 174
ALA A 175
PHE A 178
 C2X  A 260 (-3.0A)
None
None
 0.59A 4v1fC-3hiwA:
undetectable		 4v1fC-3hiwA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 9 TYR A  73
PHE A  91
TYR A 123
GLU A 174
ARG A 177
 C2X  A 260 (-3.4A)
C2X  A 260 ( 4.6A)
C2X  A 260 (-3.7A)
C2X  A 260 (-3.0A)
C2X  A 260 (-2.9A)
 0.36A 4yp2B-3hiwA:
27.5		 4yp2B-3hiwA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 9 TYR A  73
PHE A  91
TYR A 123
GLU A 174
ARG A 177
 C2X  A 260 (-3.4A)
C2X  A 260 ( 4.6A)
C2X  A 260 (-3.7A)
C2X  A 260 (-3.0A)
C2X  A 260 (-2.9A)
 0.35A 5cf9B-3hiwA:
27.5		 5cf9B-3hiwA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 6 TYR A 180
TRP A 240
LEU A 230
LEU A 212
 None
 1.21A 5xooA-3hiwA:
undetectable		 5xooA-3hiwA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 6 TYR A  73
VAL A  74
TYR A 123
GLU A 174
ARG A 177
 C2X  A 260 (-3.4A)
C2X  A 260 (-3.9A)
C2X  A 260 (-3.7A)
C2X  A 260 (-3.0A)
C2X  A 260 (-2.9A)
 0.30A 5z3jA-3hiwA:
28.5		 5z3jA-3hiwA:
27.11