SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 5 ARG A  17
ALA A 158
ASP A 237
GLY A 241
 None
 1.13A 1e7bA-3hj4A:
undetectable		 1e7bA-3hj4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 5 ARG A  17
ALA A 158
ASP A 237
GLY A 241
 None
 0.98A 1e7cA-3hj4A:
undetectable		 1e7cA-3hj4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 6 SER A 266
PHE A 336
PHE A 183
GLU A 334
 None
 1.04A 1icuA-3hj4A:
undetectable
1icuB-3hj4A:
undetectable		 1icuA-3hj4A:
19.01
1icuB-3hj4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 6 PHE A 183
GLU A 334
SER A 266
PHE A 336
 None
 0.99A 1icuA-3hj4A:
undetectable
1icuB-3hj4A:
undetectable		 1icuA-3hj4A:
19.01
1icuB-3hj4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 6 SER A 266
PHE A 336
PHE A 183
GLU A 334
 None
 0.98A 1icuC-3hj4A:
undetectable
1icuD-3hj4A:
undetectable		 1icuC-3hj4A:
19.01
1icuD-3hj4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 6 SER A 266
PHE A 336
PHE A 183
GLU A 334
 None
 0.99A 1kqbC-3hj4A:
undetectable
1kqbD-3hj4A:
undetectable		 1kqbC-3hj4A:
19.63
1kqbD-3hj4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 6 PHE A 183
GLU A 334
SER A 266
PHE A 336
 None
 1.06A 1kqbC-3hj4A:
undetectable
1kqbD-3hj4A:
undetectable		 1kqbC-3hj4A:
19.63
1kqbD-3hj4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		5 / 12 ASN A 135
SER A  69
ASP A  67
ALA A 113
ILE A 115
 None
 1.18A 1s14B-3hj4A:
undetectable		 1s14B-3hj4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		5 / 12 PHE A 251
ILE A 160
LEU A 190
VAL A 192
ALA A 189
 None
 1.00A 1v2xA-3hj4A:
undetectable		 1v2xA-3hj4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 8 PHE A 336
THR A 186
GLY A  53
ILE A 144
 None
 0.78A 2a1mB-3hj4A:
undetectable		 2a1mB-3hj4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		3 / 3 PHE A 358
VAL A 172
TRP A 166
 None
 0.75A 2cc8A-3hj4A:
undetectable		 2cc8A-3hj4A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		3 / 3 PHE A 358
VAL A 172
TRP A 166
 None
 0.73A 2ccbA-3hj4A:
undetectable		 2ccbA-3hj4A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		3 / 3 PHE A 358
VAL A 172
TRP A 166
 None
 0.74A 2vx9A-3hj4A:
undetectable		 2vx9A-3hj4A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 7 SER A 266
VAL A 280
TYR A 339
ILE A 268
 None
 1.22A 2x45B-3hj4A:
undetectable		 2x45B-3hj4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 7 SER A 266
VAL A 280
TYR A 339
ILE A 268
 None
 1.21A 2x45C-3hj4A:
undetectable		 2x45C-3hj4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		5 / 12 LEU A 162
LEU A  20
SER A  64
PRO A  62
ALA A 165
 None
 1.13A 3dfrA-3hj4A:
undetectable		 3dfrA-3hj4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 6 THR A 184
PHE A 180
PHE A 358
TYR A 255
 None
 1.33A 3elzB-3hj4A:
undetectable		 3elzB-3hj4A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		4 / 8 THR A 187
LEU A 190
GLN A 194
ASN A 338
 None
 1.05A 3kp2A-3hj4A:
undetectable
3kp2B-3hj4A:
1.4		 3kp2A-3hj4A:
16.44
3kp2B-3hj4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		3 / 3 GLN A 355
PHE A 260
TYR A 331
 None
 0.95A 3ucjB-3hj4A:
undetectable		 3ucjB-3hj4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		3 / 3 GLN A 355
PHE A 260
TYR A 331
 None
 1.00A 3ucjA-3hj4A:
undetectable		 3ucjA-3hj4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		3 / 3 PRO A 205
ASP A 216
GLU A 211
 None
 0.89A 3v4tC-3hj4A:
undetectable		 3v4tC-3hj4A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		5 / 10 VAL A 244
TYR A 159
ILE A   9
LEU A 361
LEU A 365
 None
 1.31A 4jtqA-3hj4A:
undetectable		 4jtqA-3hj4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		5 / 12 HIS A 161
LEU A 248
MET A 364
PHE A 374
HIS A  15
 None
 1.45A 4o8fB-3hj4A:
undetectable		 4o8fB-3hj4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		5 / 12 ALA A  18
PHE A 358
ILE A 354
PHE A 251
THR A 187
 None
 1.12A 5jlcA-3hj4A:
undetectable		 5jlcA-3hj4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE
(Trypanosoma
brucei) 		3 / 3 TRP A 296
GLU A 297
GLU A 311
 None
 1.01A 6fhwA-3hj4A:
undetectable		 6fhwA-3hj4A:
12.01