SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 7 ASN A 318
TYR A 322
ASN A 156
TYR A 316
 NAD  A 337 (-3.7A)
NAD  A 337 (-3.6A)
None
None
 0.96A 1dssG-3hjaA:
48.3		 1dssG-3hjaA:
50.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		7 / 7 SER A 152
THR A 154
ASN A 156
CYH A 157
TYR A 316
ASN A 318
TYR A 322
 SO4  A 336 (-3.2A)
SO4  A 336 (-3.3A)
None
None
None
NAD  A 337 (-3.7A)
NAD  A 337 (-3.6A)
 0.15A 1dssG-3hjaA:
48.3		 1dssG-3hjaA:
50.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 8 ASN A 318
TYR A 322
ASN A 156
TYR A 316
 NAD  A 337 (-3.7A)
NAD  A 337 (-3.6A)
None
None
 0.95A 1dssR-3hjaA:
48.1		 1dssR-3hjaA:
50.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		8 / 8 SER A 152
THR A 154
ASN A 156
CYH A 157
HIS A 180
TYR A 316
ASN A 318
TYR A 322
 SO4  A 336 (-3.2A)
SO4  A 336 (-3.3A)
None
None
SO4  A 336 (-4.4A)
None
NAD  A 337 (-3.7A)
NAD  A 337 (-3.6A)
 0.29A 1dssR-3hjaA:
48.1		 1dssR-3hjaA:
50.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 4 SER A 261
VAL A 297
PHE A 169
VAL A 254
 None
 1.24A 1o86A-3hjaA:
undetectable		 1o86A-3hjaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 12 ARG A  10
ILE A  26
PHE A  20
ALA A  19
GLU A 319
 None
 1.05A 2j0dA-3hjaA:
undetectable		 2j0dA-3hjaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 5 LEU A 245
LEU A 263
CYH A 157
THR A 154
 None
None
None
SO4  A 336 (-3.3A)
 1.35A 2oaxD-3hjaA:
undetectable		 2oaxD-3hjaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 VAL A 254
ASP A 253
GLU A 258
 None
 0.72A 2qeuA-3hjaA:
undetectable		 2qeuA-3hjaA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 VAL A 254
ASP A 253
GLU A 258
 None
 0.72A 2qeuC-3hjaA:
undetectable		 2qeuC-3hjaA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 12 ALA A 330
ALA A 116
VAL A 111
GLU A  92
THR A 131
 None
 1.05A 3c6gB-3hjaA:
undetectable		 3c6gB-3hjaA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 8 ASN A 318
TYR A 322
ASN A 156
TYR A 316
 NAD  A 337 (-3.7A)
NAD  A 337 (-3.6A)
None
None
 0.98A 3dmtC-3hjaA:
47.1		 3dmtC-3hjaA:
45.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		8 / 8 SER A 152
THR A 154
ASN A 156
CYH A 157
HIS A 180
TYR A 316
ASN A 318
TYR A 322
 SO4  A 336 (-3.2A)
SO4  A 336 (-3.3A)
None
None
SO4  A 336 (-4.4A)
None
NAD  A 337 (-3.7A)
NAD  A 337 (-3.6A)
 0.24A 3dmtC-3hjaA:
47.1		 3dmtC-3hjaA:
45.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 7 ASP A 127
VAL A 119
ILE A 120
TYR A 107
 None
 0.93A 3pglA-3hjaA:
3.5		 3pglA-3hjaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 12 GLU A 319
PHE A  48
ILE A  91
GLY A   9
ILE A  11
 None
None
None
NAD  A 337 (-3.3A)
NAD  A 337 (-4.2A)
 1.41A 4djfA-3hjaA:
undetectable		 4djfA-3hjaA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 8 PRO A 124
SER A 152
VAL A  96
GLY A  95
 None
SO4  A 336 (-3.2A)
NAD  A 337 ( 4.9A)
NAD  A 337 (-3.2A)
 1.02A 4klrB-3hjaA:
3.4		 4klrB-3hjaA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 7 THR A 183
ARG A 198
SER A 232
HIS A 180
 SO4  A 338 (-2.8A)
SO4  A 338 (-3.5A)
SO4  A 336 ( 4.6A)
SO4  A 336 (-4.4A)
 1.25A 4o4dA-3hjaA:
undetectable		 4o4dA-3hjaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 11 SER A 152
LEU A 158
PRO A 160
VAL A 133
THR A 131
 SO4  A 336 (-3.2A)
None
None
None
None
 1.15A 4uuuB-3hjaA:
undetectable		 4uuuB-3hjaA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 THR A 155
ALA A 151
ASN A 156
 None
 0.54A 5ersA-3hjaA:
2.2		 5ersA-3hjaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 11 LEU A 313
ALA A 310
ILE A 171
GLY A 174
ILE A 312
 None
 1.02A 5kr2B-3hjaA:
undetectable		 5kr2B-3hjaA:
14.89