SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hjb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 LEU A 343
PHE A 346
MET A 165
ILE A 473
TRP A 275
 None
 1.44A 1hrkB-3hjbA:
2.2		 1hrkB-3hjbA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 8 LEU A 295
PHE A 291
LEU A 205
SER A 273
 None
 1.03A 1wrlC-3hjbA:
undetectable
1wrlD-3hjbA:
undetectable		 1wrlC-3hjbA:
9.12
1wrlD-3hjbA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 7 ILE A 494
TYR A 490
ASP A 403
GLU A 334
 None
 1.00A 2qebA-3hjbA:
undetectable		 2qebA-3hjbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 7 ILE A 494
TYR A 490
ASP A 403
GLU A 334
 None
 0.98A 2qebB-3hjbA:
undetectable		 2qebB-3hjbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 PRO A 315
PHE A 350
LYS A 493
 None
 1.26A 3bjwG-3hjbA:
undetectable		 3bjwG-3hjbA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 7 TYR A 288
ASN A 122
LEU A 125
LYS A 129
 None
 1.35A 3lslA-3hjbA:
undetectable
3lslD-3hjbA:
undetectable		 3lslA-3hjbA:
17.74
3lslD-3hjbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 7 TYR A 288
ASN A 122
LEU A 125
LYS A 129
 None
 1.43A 3lslA-3hjbA:
undetectable
3lslD-3hjbA:
undetectable		 3lslA-3hjbA:
17.74
3lslD-3hjbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 6 TYR A 288
ASN A 122
LEU A 125
LYS A 129
 None
 1.45A 3lslG-3hjbA:
undetectable		 3lslG-3hjbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 7 ASN A 502
TYR A 361
PRO A   7
TYR A 371
 None
 1.30A 3ugrA-3hjbA:
undetectable		 3ugrA-3hjbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 SER A 333
ASP A 403
ASP A  53
 None
 0.79A 3uj7A-3hjbA:
undetectable		 3uj7A-3hjbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 ASN A 485
ALA A 488
LEU A 274
LEU A 295
PHE A  46
 None
 1.45A 3vhuA-3hjbA:
undetectable		 3vhuA-3hjbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 ILE A 317
LEU A 318
LEU A 486
MET A 489
HIS A 304
 None
 0.96A 3vn2A-3hjbA:
undetectable		 3vn2A-3hjbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 VAL A 124
PHE A 291
ILE A 487
VAL A 268
VAL A 121
 CL  A 557 ( 4.3A)
None
None
None
None
 0.97A 3w68D-3hjbA:
undetectable		 3w68D-3hjbA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 9 ALA A 296
ARG A 481
GLY A 484
LEU A 483
ILE A 282
 None
 1.15A 3wdmA-3hjbA:
2.6		 3wdmA-3hjbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 5 ILE A 336
ILE A 494
TYR A 490
GLU A 491
 None
 1.23A 4a99D-3hjbA:
undetectable		 4a99D-3hjbA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 HIS A  99
SER A 357
GLY A 498
SER A 505
VAL A 499
 None
 1.18A 4danA-3hjbA:
undetectable
4danB-3hjbA:
undetectable		 4danA-3hjbA:
20.63
4danB-3hjbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 7 PHE A 346
VAL A 166
GLY A 484
PHE A 350
 None
 0.82A 4ejjB-3hjbA:
undetectable		 4ejjB-3hjbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 PHE A 254
VAL A 237
GLU A 234
 None
None
CA  A 553 ( 4.6A)
 0.72A 4fvqA-3hjbA:
undetectable		 4fvqA-3hjbA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		6 / 12 ILE A 478
LEU A 294
TRP A 275
ILE A 282
GLY A 162
LEU A 343
 None
 1.43A 4o1zA-3hjbA:
undetectable		 4o1zA-3hjbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 11 TRP A 140
GLY A 142
PHE A 241
ILE A 256
ASN A 260
 None
 1.24A 4rtrA-3hjbA:
undetectable		 4rtrA-3hjbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 TRP A 140
GLY A 142
PHE A 241
ILE A 256
ASN A 260
 None
 1.17A 4rtsA-3hjbA:
undetectable		 4rtsA-3hjbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 ASN A 260
LEU A 284
PHE A 241
 None
 0.82A 5dsgA-3hjbA:
undetectable		 5dsgA-3hjbA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 PRO A 407
LEU A 170
SER A 410
 None
 0.80A 5fsaB-3hjbA:
undetectable		 5fsaB-3hjbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 ILE A 487
ALA A 488
GLY A 297
GLY A 162
VAL A 166
 None
 1.16A 5i71A-3hjbA:
undetectable		 5i71A-3hjbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 GLY A 269
GLY A 270
GLN A 508
 None
 0.35A 5imsA-3hjbA:
2.9		 5imsA-3hjbA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 THR A 167
PHE A 204
ALA A 223
SER A 159
ILE A 156
 None
 1.35A 5iwuA-3hjbA:
undetectable		 5iwuA-3hjbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 ARG A 103
LEU A 486
ALA A 169
GLY A 297
ALA A 298
 None
 0.93A 5jw1B-3hjbA:
undetectable		 5jw1B-3hjbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 LEU A 161
THR A 216
ASN A 219
 None
 0.71A 6baaE-3hjbA:
undetectable		 6baaE-3hjbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 LEU A 161
THR A 216
ASN A 219
 None
 0.71A 6baaF-3hjbA:
0.0		 6baaF-3hjbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 LEU A 161
THR A 216
ASN A 219
 None
 0.71A 6baaG-3hjbA:
undetectable		 6baaG-3hjbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		3 / 3 LEU A 161
THR A 216
ASN A 219
 None
 0.72A 6baaH-3hjbA:
undetectable		 6baaH-3hjbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		5 / 12 GLU A 311
PHE A  68
PHE A 495
PHE A 305
ILE A   5
 None
 1.47A 6becA-3hjbA:
undetectable
6becB-3hjbA:
undetectable
6becC-3hjbA:
undetectable		 6becA-3hjbA:
22.22
6becB-3hjbA:
22.22
6becC-3hjbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE
(Vibrio
cholerae) 		4 / 6 SER A 159
ALA A 277
SER A 276
ALA A 207
 None
 0.82A 6bocA-3hjbA:
undetectable
6bocB-3hjbA:
undetectable
6bocC-3hjbA:
undetectable
6bocD-3hjbA:
undetectable		 6bocA-3hjbA:
5.52
6bocB-3hjbA:
5.52
6bocC-3hjbA:
5.52
6bocD-3hjbA:
5.52