SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hjc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 7 LEU A 210
SER A 206
ASP A 205
PHE A 215
 None
 1.25A 1ismB-3hjcA:
undetectable		 1ismB-3hjcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		3 / 3 ARG A 355
ARG A 347
ARG A 356
 None
 0.91A 1l7fA-3hjcA:
undetectable		 1l7fA-3hjcA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		3 / 3 ARG A 355
ARG A 347
ARG A 356
 None
 0.90A 1l7hA-3hjcA:
undetectable		 1l7hA-3hjcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		5 / 12 ILE A 153
GLY A 150
ILE A 233
PHE A 132
ALA A  55
 None
 0.92A 1nv8B-3hjcA:
undetectable		 1nv8B-3hjcA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 7 GLY A  91
PRO A  52
PHE A 149
ASN A 152
 None
 0.95A 1oniG-3hjcA:
undetectable
1oniI-3hjcA:
undetectable		 1oniG-3hjcA:
14.45
1oniI-3hjcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 8 ILE A 157
TYR A 146
THR A 184
LEU A 185
 None
 0.91A 3abmN-3hjcA:
undetectable
3abmW-3hjcA:
undetectable		 3abmN-3hjcA:
18.41
3abmW-3hjcA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		3 / 3 TYR A 142
MET A  49
LEU A  90
 None
 0.56A 3vw1D-3hjcA:
undetectable		 3vw1D-3hjcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 6 ILE A 157
TYR A 146
THR A 184
LEU A 185
 None
 0.98A 3wg7N-3hjcA:
undetectable
3wg7W-3hjcA:
undetectable		 3wg7N-3hjcA:
18.41
3wg7W-3hjcA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		3 / 3 LEU A 210
GLU A 211
SER A 213
 None
 0.74A 4ccqA-3hjcA:
undetectable		 4ccqA-3hjcA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 5 LEU A 287
LEU A 379
THR A 341
PRO A 214
 None
 1.03A 6ew0F-3hjcA:
undetectable		 6ew0F-3hjcA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3hjc HEAT SHOCK PROTEIN
83-1
(Leishmania
major) 		4 / 6 LEU A 287
LEU A 379
THR A 341
PRO A 214
 None
 1.02A 6ew0G-3hjcA:
undetectable		 6ew0G-3hjcA:
10.81