SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hje'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		8 / 12 HIS A  46
TYR A  48
LEU A 193
ASP A 222
HIS A 440
ASP A 441
ASP A 593
ARG A 597
 GOL  A 803 (-3.6A)
GOL  A 802 ( 4.3A)
None
GOL  A 802 (-2.8A)
None
GOL  A 802 ( 3.7A)
GOL  A 803 (-3.0A)
GOL  A 803 (-2.7A)
 0.73A 1dedA-3hjeA:
22.4		 1dedA-3hjeA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		7 / 12 HIS A  46
TYR A  48
LEU A 193
GLU A 249
ASP A 441
ASP A 593
ARG A 597
 GOL  A 803 (-3.6A)
GOL  A 802 ( 4.3A)
None
GOL  A 804 (-3.8A)
GOL  A 802 ( 3.7A)
GOL  A 803 (-3.0A)
GOL  A 803 (-2.7A)
 0.99A 1dedA-3hjeA:
22.4		 1dedA-3hjeA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		9 / 12 HIS A  46
TYR A  48
LEU A 193
ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
ARG A 597
 GOL  A 803 (-3.6A)
GOL  A 802 ( 4.3A)
None
None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
GOL  A 803 (-2.7A)
 0.76A 1dedB-3hjeA:
22.4		 1dedB-3hjeA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A 490
GLY A 491
SER A 456
PHE A 552
MET A 559
 None
 1.19A 1fduC-3hjeA:
undetectable		 1fduC-3hjeA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 PRO A 575
GLY A 265
GLY A 268
ASP A 270
VAL A 248
 None
 1.13A 1ffyA-3hjeA:
undetectable		 1ffyA-3hjeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 PHE A 549
TRP A 469
GLU A 468
 None
 1.18A 1mogA-3hjeA:
undetectable		 1mogA-3hjeA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		8 / 12 TYR A  48
HIS A  88
PHE A 187
ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 GOL  A 802 ( 4.3A)
GOL  A 802 (-3.9A)
GOL  A 802 (-3.7A)
None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.64A 1mxdA-3hjeA:
19.5		 1mxdA-3hjeA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 343
ASP A 115
ASN A 112
 None
 0.88A 1nbhA-3hjeA:
2.1		 1nbhA-3hjeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 343
ASP A 115
ASN A 112
 None
 0.86A 1nbhD-3hjeA:
undetectable		 1nbhD-3hjeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 PRO A 575
GLY A 265
GLY A 268
ASP A 270
VAL A 248
 None
 1.13A 1qu2A-3hjeA:
undetectable		 1qu2A-3hjeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 THR A 667
GLY A 651
ASP A 419
LEU A 426
LEU A 570
 None
 1.10A 1r30A-3hjeA:
6.5		 1r30A-3hjeA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 226
MET A 382
ILE A 224
PRO A 230
 None
 1.00A 1rxcD-3hjeA:
undetectable		 1rxcD-3hjeA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 LEU A 432
HIS A  31
ILE A  81
 None
 0.63A 1s9pB-3hjeA:
undetectable		 1s9pB-3hjeA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 9 LYS A 620
ILE A 619
GLY A 560
TYR A 589
PHE A 614
 None
 1.10A 1td7A-3hjeA:
undetectable		 1td7A-3hjeA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 ALA A 454
ASP A 671
TYR A 672
LYS A 666
 None
 1.30A 2dpzA-3hjeA:
undetectable		 2dpzA-3hjeA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A 345
MET A 382
LYS A 250
LEU A 339
ARG A 259
 None
 1.29A 2mjiA-3hjeA:
undetectable		 2mjiA-3hjeA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A 269
ASP A 222
TYR A  48
HIS A 440
 None
GOL  A 802 (-2.8A)
GOL  A 802 ( 4.3A)
None
 1.41A 2pncA-3hjeA:
undetectable		 2pncA-3hjeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 554
PHE A 493
ILE A 489
PHE A 496
 None
 1.02A 2qeiA-3hjeA:
undetectable		 2qeiA-3hjeA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 TYR A 113
LEU A  98
ASN A  95
ASP A  49
 None
 1.24A 2w98A-3hjeA:
undetectable
2w98B-3hjeA:
undetectable		 2w98A-3hjeA:
19.72
2w98B-3hjeA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A 589
SER A 445
ILE A 452
SER A 564
 None
 1.30A 2xz5A-3hjeA:
undetectable
2xz5B-3hjeA:
undetectable		 2xz5A-3hjeA:
14.75
2xz5B-3hjeA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.73A 3aicA-3hjeA:
4.2		 3aicA-3hjeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.70A 3aicB-3hjeA:
3.4		 3aicB-3hjeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		6 / 12 ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
TYR A  48
 None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
GOL  A 802 ( 4.3A)
 0.72A 3aicC-3hjeA:
4.5		 3aicC-3hjeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.80A 3aicD-3hjeA:
4.6		 3aicD-3hjeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.76A 3aicE-3hjeA:
4.6		 3aicE-3hjeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.72A 3aicF-3hjeA:
4.5		 3aicF-3hjeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.71A 3aicG-3hjeA:
4.6		 3aicG-3hjeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.79A 3aicH-3hjeA:
4.9		 3aicH-3hjeA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 PHE A 493
GLY A 491
VAL A 448
LEU A 591
 None
 1.05A 3bgdB-3hjeA:
undetectable		 3bgdB-3hjeA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 11 ASP A 311
LEU A 336
SER A 337
PHE A 335
ILE A 332
 None
 1.49A 3ko0K-3hjeA:
0.6
3ko0L-3hjeA:
0.6
3ko0M-3hjeA:
0.6
3ko0N-3hjeA:
0.6		 3ko0K-3hjeA:
9.66
3ko0L-3hjeA:
9.66
3ko0M-3hjeA:
9.66
3ko0N-3hjeA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 9 PHE A 655
LEU A 698
ILE A 572
ARG A 631
TYR A 622
 None
 1.45A 3m7rA-3hjeA:
undetectable		 3m7rA-3hjeA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 ILE A 263
LEU A 234
VAL A 341
SER A 253
 None
 1.01A 3r9vA-3hjeA:
undetectable
3r9vB-3hjeA:
1.5		 3r9vA-3hjeA:
17.85
3r9vB-3hjeA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 ASP A 222
PRO A  36
GLN A  82
ARG A 597
 GOL  A 802 (-2.8A)
None
None
GOL  A 803 (-2.7A)
 1.29A 3s3oA-3hjeA:
2.6		 3s3oA-3hjeA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 535
SER A 492
MET A 508
TYR A 486
THR A 488
 None
 1.50A 3thrA-3hjeA:
undetectable
3thrB-3hjeA:
undetectable
3thrC-3hjeA:
undetectable
3thrD-3hjeA:
undetectable		 3thrA-3hjeA:
17.40
3thrB-3hjeA:
17.40
3thrC-3hjeA:
17.40
3thrD-3hjeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 PHE A 271
THR A 573
PRO A 575
PHE A 655
 None
 1.11A 3tzfB-3hjeA:
3.9		 3tzfB-3hjeA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 ARG A 588
ASP A 441
GLU A 514
LEU A 590
 None
GOL  A 802 ( 3.7A)
None
None
 1.27A 4ax8A-3hjeA:
undetectable		 4ax8A-3hjeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 468
ASN A 467
LEU A 535
SER A 548
ILE A 472
 None
 1.44A 4djeA-3hjeA:
4.3		 4djeA-3hjeA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A 478
LEU A 294
HIS A 518
TYR A 528
 None
 1.22A 4f5zA-3hjeA:
undetectable		 4f5zA-3hjeA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 ASP A 222
ASP A 593
ASP A 441
GLU A 249
 GOL  A 802 (-2.8A)
GOL  A 803 (-3.0A)
GOL  A 802 ( 3.7A)
GOL  A 804 (-3.8A)
 1.17A 4feuB-3hjeA:
undetectable		 4feuB-3hjeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 ASP A 222
ASP A 593
ASP A 441
GLU A 249
 GOL  A 802 (-2.8A)
GOL  A 803 (-3.0A)
GOL  A 802 ( 3.7A)
GOL  A 804 (-3.8A)
 1.19A 4fevF-3hjeA:
undetectable		 4fevF-3hjeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A 222
ASP A 593
ASP A 441
GLU A 249
 GOL  A 802 (-2.8A)
GOL  A 803 (-3.0A)
GOL  A 802 ( 3.7A)
GOL  A 804 (-3.8A)
 1.18A 4fewD-3hjeA:
undetectable		 4fewD-3hjeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A 222
ASP A 593
ASP A 441
GLU A 249
 GOL  A 802 (-2.8A)
GOL  A 803 (-3.0A)
GOL  A 802 ( 3.7A)
GOL  A 804 (-3.8A)
 1.18A 4fewF-3hjeA:
undetectable		 4fewF-3hjeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A   8
HIS A 440
TYR A  33
 None
 1.34A 4fu9A-3hjeA:
undetectable		 4fu9A-3hjeA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 7 ASP A 222
ASP A 593
ASP A 441
GLU A 249
 GOL  A 802 (-2.8A)
GOL  A 803 (-3.0A)
GOL  A 802 ( 3.7A)
GOL  A 804 (-3.8A)
 1.17A 4gkhG-3hjeA:
undetectable		 4gkhG-3hjeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A 222
ASP A 593
ASP A 441
GLU A 249
 GOL  A 802 (-2.8A)
GOL  A 803 (-3.0A)
GOL  A 802 ( 3.7A)
GOL  A 804 (-3.8A)
 1.17A 4gkiA-3hjeA:
undetectable		 4gkiA-3hjeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A 222
ASP A 593
ASP A 441
GLU A 249
 GOL  A 802 (-2.8A)
GOL  A 803 (-3.0A)
GOL  A 802 ( 3.7A)
GOL  A 804 (-3.8A)
 1.18A 4gkiC-3hjeA:
undetectable		 4gkiC-3hjeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 5 ILE A 321
ASN A 328
TYR A 329
ILE A 318
 None
 1.06A 4jtpA-3hjeA:
undetectable		 4jtpA-3hjeA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 LEU A 535
ILE A 536
LEU A 485
TYR A 486
 None
 0.85A 4w5nA-3hjeA:
2.1		 4w5nA-3hjeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 179
ASP A 177
TRP A 178
 None
 1.13A 4xdqA-3hjeA:
undetectable		 4xdqA-3hjeA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 5 ASP A  71
VAL A 216
ASP A 217
GLY A  79
 None
 1.26A 4xp6A-3hjeA:
0.0		 4xp6A-3hjeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 ARG A 588
ARG A 503
ASP A 595
VAL A 600
 None
 1.40A 4xqeA-3hjeA:
undetectable		 4xqeA-3hjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 ARG A 588
ARG A 503
ASP A 595
VAL A 600
 None
 1.41A 4xqeB-3hjeA:
undetectable		 4xqeB-3hjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 5 GLU A 249
TYR A  48
ARG A   8
ARG A 220
 GOL  A 804 (-3.8A)
GOL  A 802 ( 4.3A)
None
None
 1.46A 4yshB-3hjeA:
0.8		 4yshB-3hjeA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		6 / 12 ASP A 392
ARG A 220
ASP A 222
GLU A 249
HIS A 440
ASP A 441
 None
None
GOL  A 802 (-2.8A)
GOL  A 804 (-3.8A)
None
GOL  A 802 ( 3.7A)
 0.88A 5csyB-3hjeA:
13.2		 5csyB-3hjeA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A 627
PRO A 699
ILE A 701
LEU A 630
 None
 0.93A 5g48A-3hjeA:
undetectable		 5g48A-3hjeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 10 TYR A 233
ILE A 221
VAL A  50
ILE A 211
LEU A  38
 None
 1.18A 5ienB-3hjeA:
undetectable		 5ienB-3hjeA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 TYR A  53
TYR A 233
GLN A 198
 None
 1.17A 5jsdA-3hjeA:
undetectable
5jsdB-3hjeA:
undetectable		 5jsdA-3hjeA:
21.82
5jsdB-3hjeA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A 118
TYR A 117
ARG A 320
 None
 0.81A 5uunA-3hjeA:
undetectable		 5uunA-3hjeA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 468
LEU A 535
SER A 548
PHE A 552
ILE A 472
 None
 1.11A 5vooD-3hjeA:
7.1		 5vooD-3hjeA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 468
LEU A 535
SER A 548
PHE A 552
ILE A 472
 None
 1.14A 5vooF-3hjeA:
6.5		 5vooF-3hjeA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 SER A 564
THR A 488
ILE A 489
LEU A 584
PHE A 549
 None
 1.29A 6a93A-3hjeA:
undetectable		 6a93A-3hjeA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A  48
HIS A  88
ASP A 222
HIS A 440
ASP A 441
 GOL  A 802 ( 4.3A)
GOL  A 802 (-3.9A)
GOL  A 802 (-2.8A)
None
GOL  A 802 ( 3.7A)
 0.61A 6ag0A-3hjeA:
16.1		 6ag0A-3hjeA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		4 / 6 LEU A   3
VAL A 600
PHE A 247
GLY A 218
 None
 0.98A 6hd4B-3hjeA:
undetectable		 6hd4B-3hjeA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 428
PHE A 638
PHE A 271
 None
 1.09A 6nknC-3hjeA:
undetectable
6nknJ-3hjeA:
undetectable		 6nknC-3hjeA:
15.23
6nknJ-3hjeA:
6.37