SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hjl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 7 PHE A 239
ALA A 265
LEU A 262
VAL A 257
 None
 0.94A 1hk2A-3hjlA:
undetectable		 1hk2A-3hjlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 6 VAL A 174
GLU A 127
LEU A 134
PHE A 135
 None
 1.04A 1s8fB-3hjlA:
undetectable		 1s8fB-3hjlA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		3 / 3 ILE A 264
ASP A 292
PHE A 289
 None
 0.57A 1uwjB-3hjlA:
undetectable		 1uwjB-3hjlA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 12 LEU A  38
LEU A  41
LEU A  44
ALA A  45
LEU A  21
 None
 0.90A 1ya3C-3hjlA:
undetectable		 1ya3C-3hjlA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 5 LEU A 151
PRO A 152
LEU A 155
ILE A 132
 None
 0.82A 2qd4A-3hjlA:
undetectable		 2qd4A-3hjlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 12 LEU A  64
LEU A  63
PHE A  80
ILE A  72
ALA A  70
 None
 1.15A 2v0mC-3hjlA:
undetectable		 2v0mC-3hjlA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 5 GLN A 308
ALA A 269
ILE A 273
ARG A 243
 None
 1.50A 2z0aA-3hjlA:
undetectable		 2z0aA-3hjlA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 8 SER A 279
ILE A 242
LEU A 262
ASN A 280
 None
 0.76A 3dcjB-3hjlA:
undetectable		 3dcjB-3hjlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 9 LEU A  17
SER A  20
PHE A  80
VAL A  87
ALA A  60
 None
 1.36A 3unaB-3hjlA:
undetectable		 3unaB-3hjlA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 4 LEU A 266
ALA A 307
ILE A 264
LYS A 274
 None
 1.27A 4eixA-3hjlA:
undetectable		 4eixA-3hjlA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 4 LEU A 151
PRO A 152
LEU A 155
ILE A 132
 None
 0.88A 4f4dB-3hjlA:
undetectable		 4f4dB-3hjlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 12 PHE A 289
ALA A 269
ALA A 265
THR A 261
VAL A 257
 None
 1.12A 4j6dA-3hjlA:
undetectable		 4j6dA-3hjlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 12 PHE A 289
ALA A 269
ALA A 265
THR A 261
VAL A 257
 None
 1.12A 4j6dB-3hjlA:
undetectable		 4j6dB-3hjlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 12 ILE A 112
LEU A 136
LEU A 181
ALA A 121
SER A 117
 None
 1.48A 4m11D-3hjlA:
undetectable		 4m11D-3hjlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 12 LEU A 266
PHE A 277
ILE A 253
VAL A 311
VAL A 312
 None
 0.98A 4nkxC-3hjlA:
undetectable		 4nkxC-3hjlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 12 LEU A 266
PHE A 277
ILE A 253
VAL A 311
VAL A 312
 None
 1.00A 4nkxD-3hjlA:
undetectable		 4nkxD-3hjlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 12 LEU A 262
ILE A 314
ALA A 307
ILE A 242
PHE A 239
 None
 1.23A 4rp8C-3hjlA:
undetectable		 4rp8C-3hjlA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 7 GLY A 198
ARG A 231
ALA A 202
ILE A 232
 None
 0.90A 4txnA-3hjlA:
undetectable		 4txnA-3hjlA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 7 GLY A 198
ARG A 231
ALA A 202
ILE A 232
 None
 0.92A 4txnB-3hjlA:
undetectable		 4txnB-3hjlA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 7 GLY A 198
ARG A 231
ALA A 202
ILE A 232
 None
 0.90A 4txnC-3hjlA:
undetectable		 4txnC-3hjlA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		4 / 7 GLY A 198
ARG A 231
ALA A 202
ILE A 232
 None
 0.90A 4txnD-3hjlA:
undetectable		 4txnD-3hjlA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG
(Aquifex
aeolicus) 		5 / 9 PHE A  80
ALA A  60
SER A  20
LEU A  17
VAL A  16
 None
 1.24A 4z69A-3hjlA:
undetectable		 4z69A-3hjlA:
21.02