SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hjn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 ASN A 103
GLY A  99
GLN A  98
VAL A  95
LEU A 151
 None
None
TYD  A 401 (-3.0A)
None
None
 1.35A 1nhzA-3hjnA:
undetectable		 1nhzA-3hjnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		3 / 3 GLN A  16
HIS A 182
ARG A 183
 None
 1.08A 1zlqA-3hjnA:
undetectable		 1zlqA-3hjnA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		3 / 3 GLY A 105
GLU A 107
ASN A 103
 None
 0.66A 1zq9A-3hjnA:
undetectable		 1zq9A-3hjnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		4 / 6 TYR A  97
GLY A  38
SER A  67
ARG A  47
 TYD  A 401 (-3.8A)
None
None
TYD  A 401 (-2.9A)
 1.35A 2a3cB-3hjnA:
undetectable		 2a3cB-3hjnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  43
GLY A  39
GLU A  44
ARG A  47
GLU A  36
 None
None
None
TYD  A 401 (-2.9A)
None
 1.17A 2vdvE-3hjnA:
undetectable		 2vdvE-3hjnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 11 GLY A  43
GLY A  39
GLU A  44
ARG A  47
GLU A  36
 None
None
None
TYD  A 401 (-2.9A)
None
 1.16A 2vdvF-3hjnA:
undetectable		 2vdvF-3hjnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GF2_A_SALA147_1
(146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		4 / 4 TYR A  97
LEU A 151
ARG A 155
TYR A 158
 TYD  A 401 (-3.8A)
None
None
None
 1.17A 3gf2A-3hjnA:
0.0		 3gf2A-3hjnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 SER A  94
TYR A  97
ALA A 135
PHE A 150
LEU A 151
 TYD  A 401 (-2.7A)
TYD  A 401 (-3.8A)
None
None
None
 1.34A 3vw1B-3hjnA:
undetectable		 3vw1B-3hjnA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		3 / 3 ARG A 187
GLU A 188
PHE A 126
 None
 0.81A 4kszA-3hjnA:
undetectable		 4kszA-3hjnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		4 / 6 LYS A  45
GLY A  38
SER A  67
LEU A  70
 None
 1.25A 5bphD-3hjnA:
3.5		 5bphD-3hjnA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 LEU A  63
GLY A  38
ASP A   9
ASN A 143
PHE A 145
 None
None
TYD  A 401 (-2.9A)
TYD  A 401 (-3.2A)
TYD  A 401 (-4.0A)
 1.28A 5d0yA-3hjnA:
undetectable		 5d0yA-3hjnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.22A 5jhnB-3hjnA:
undetectable		 5jhnB-3hjnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.18A 5jinA-3hjnA:
undetectable		 5jinA-3hjnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.20A 5jj0A-3hjnA:
undetectable		 5jj0A-3hjnA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.20A 5t0kA-3hjnA:
undetectable		 5t0kA-3hjnA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.21A 5t0mB-3hjnA:
undetectable		 5t0mB-3hjnA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.10A 5tuyA-3hjnA:
undetectable		 5tuyA-3hjnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.11A 5tuyB-3hjnA:
undetectable		 5tuyB-3hjnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		4 / 4 SER A  11
THR A 125
ASP A 123
ASP A  88
 ADP  A 301 (-3.3A)
None
None
MG  A 501 ( 4.0A)
 1.33A 5vimA-3hjnA:
undetectable		 5vimA-3hjnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3hjn THYMIDYLATE KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  10
SER A  93
TYR A  97
TYR A 127
GLN A  16
 ADP  A 301 (-3.4A)
TYD  A 401 (-4.0A)
TYD  A 401 (-3.8A)
None
None
 1.12A 5vscA-3hjnA:
undetectable		 5vscA-3hjnA:
20.36