SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hjr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
3 / 3 LEU A 486
SER A 509
ASN A 243
None
0.78A 1bx4A-3hjrA:
undetectable
1bx4A-3hjrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 LEU A 504
ARG A 232
MET A 531
GLY A 527
LEU A 481
None
1.16A 1g50B-3hjrA:
undetectable
1g50B-3hjrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 11 LEU A 504
ARG A 232
MET A 531
GLY A 527
LEU A 481
None
1.15A 1g50C-3hjrA:
undetectable
1g50C-3hjrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 LEU A 489
LEU A 486
GLN A 513
ALA A 555
PHE A 507
None
0.91A 1gs4A-3hjrA:
undetectable
1gs4A-3hjrA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 493
LEU A 549
SER A 462
THR A 464
None
0.76A 1ictD-3hjrA:
undetectable
1ictD-3hjrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
3 / 3 ARG A 362
ASP A 197
ASN A 189
None
0.91A 1nbhA-3hjrA:
2.1
1nbhA-3hjrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
3 / 3 ARG A 362
ASP A 197
ASN A 189
None
0.89A 1nbhD-3hjrA:
1.8
1nbhD-3hjrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 ASN A 250
ASN A 245
ILE A 277
GLY A 274
None
1.09A 1oniA-3hjrA:
undetectable
1oniB-3hjrA:
undetectable
1oniA-3hjrA:
12.59
1oniB-3hjrA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 ASN A 250
ASN A 245
ILE A 277
GLY A 274
None
1.08A 1oniD-3hjrA:
undetectable
1oniF-3hjrA:
undetectable
1oniD-3hjrA:
12.59
1oniF-3hjrA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 ASP A 170
PHE A 174
SER A 165
ALA A 210
None
0.94A 1rqpC-3hjrA:
4.1
1rqpC-3hjrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 ASP A 170
PHE A 174
SER A 165
ALA A 210
None
0.93A 1rqpA-3hjrA:
3.9
1rqpA-3hjrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 GLY A 300
HIS A  85
ASP A 297
TYR A 328
CA  A 603 (-4.3A)
None
CA  A 603 (-3.4A)
None
1.09A 1th6A-3hjrA:
undetectable
1th6A-3hjrA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.90A 1v54C-3hjrA:
undetectable
1v54J-3hjrA:
undetectable
1v54C-3hjrA:
17.67
1v54J-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.92A 1v54P-3hjrA:
undetectable
1v54W-3hjrA:
undetectable
1v54P-3hjrA:
17.67
1v54W-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 HIS A 483
LEU A 490
PRO A 459
ILE A 452
SER A 462
None
1.48A 1xmuA-3hjrA:
undetectable
1xmuA-3hjrA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 GLY A 300
HIS A  85
ASP A 297
TYR A 328
CA  A 603 (-4.3A)
None
CA  A 603 (-3.4A)
None
1.10A 2armA-3hjrA:
undetectable
2armA-3hjrA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.91A 2dyrC-3hjrA:
undetectable
2dyrJ-3hjrA:
undetectable
2dyrC-3hjrA:
17.67
2dyrJ-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.91A 2dyrP-3hjrA:
undetectable
2dyrW-3hjrA:
undetectable
2dyrP-3hjrA:
17.67
2dyrW-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.97A 2eikC-3hjrA:
undetectable
2eikJ-3hjrA:
undetectable
2eikC-3hjrA:
17.67
2eikJ-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 SER A 409
SER A 280
LEU A 416
GLY A 415
None
0.90A 2j2pA-3hjrA:
undetectable
2j2pC-3hjrA:
undetectable
2j2pA-3hjrA:
16.00
2j2pC-3hjrA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 SER A 409
SER A 280
LEU A 416
GLY A 415
None
0.89A 2j2pD-3hjrA:
undetectable
2j2pF-3hjrA:
undetectable
2j2pD-3hjrA:
16.00
2j2pF-3hjrA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 GLY A 143
GLY A  95
VAL A  76
ASN A  98
PRO A 108
None
1.19A 2okcB-3hjrA:
undetectable
2okcB-3hjrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 ASP A 170
PHE A 174
SER A 165
ALA A 210
None
0.92A 2v7uA-3hjrA:
4.0
2v7uA-3hjrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 ARG A 577
GLN A 517
ARG A 580
GLN A 581
None
1.49A 2vxaA-3hjrA:
undetectable
2vxaB-3hjrA:
undetectable
2vxaK-3hjrA:
undetectable
2vxaA-3hjrA:
8.89
2vxaB-3hjrA:
8.89
2vxaK-3hjrA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 ARG A 577
GLN A 517
ARG A 580
GLN A 581
None
1.49A 2vxaA-3hjrA:
undetectable
2vxaK-3hjrA:
undetectable
2vxaL-3hjrA:
undetectable
2vxaA-3hjrA:
8.89
2vxaK-3hjrA:
8.89
2vxaL-3hjrA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 GLY A 344
ALA A 345
MET A 346
LEU A 349
None
0.31A 2wekB-3hjrA:
undetectable
2wekB-3hjrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.96A 3ag2C-3hjrA:
undetectable
3ag2C-3hjrA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.99A 3ag2P-3hjrA:
undetectable
3ag2W-3hjrA:
undetectable
3ag2P-3hjrA:
17.67
3ag2W-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.90A 3ag4C-3hjrA:
undetectable
3ag4J-3hjrA:
undetectable
3ag4C-3hjrA:
17.67
3ag4J-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.94A 3ag4P-3hjrA:
undetectable
3ag4W-3hjrA:
undetectable
3ag4P-3hjrA:
17.67
3ag4W-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 ASN A 189
SER A 190
ALA A 188
ASP A 197
None
1.32A 3aruA-3hjrA:
2.7
3aruA-3hjrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.91A 3asnC-3hjrA:
undetectable
3asnJ-3hjrA:
undetectable
3asnC-3hjrA:
17.67
3asnJ-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 GLN A 176
GLY A 121
SER A 341
THR A 342
VAL A  74
None
1.26A 3d91B-3hjrA:
undetectable
3d91B-3hjrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
6 / 12 GLY A 219
GLY A 217
GLY A 334
LEU A 246
ASN A 508
ILE A 223
None
1.04A 3elwA-3hjrA:
undetectable
3elwA-3hjrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 9 LEU A 246
VAL A 511
ILE A 223
LEU A 230
PHE A 241
None
1.39A 3fl9D-3hjrA:
undetectable
3fl9D-3hjrA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 SER A 336
GLY A 219
GLY A 217
GLY A 334
ILE A 223
None
0.92A 3gczA-3hjrA:
undetectable
3gczA-3hjrA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 11 LEU A 504
ARG A 232
MET A 531
GLY A 527
LEU A 481
None
1.29A 3hm1B-3hjrA:
undetectable
3hm1B-3hjrA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 LEU A 246
ASN A 276
GLY A 274
LEU A 504
GLU A 242
None
1.15A 3medA-3hjrA:
undetectable
3medB-3hjrA:
undetectable
3medA-3hjrA:
21.73
3medB-3hjrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.87A 3x2qC-3hjrA:
undetectable
3x2qJ-3hjrA:
undetectable
3x2qC-3hjrA:
17.67
3x2qJ-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.88A 3x2qP-3hjrA:
undetectable
3x2qW-3hjrA:
undetectable
3x2qP-3hjrA:
17.67
3x2qW-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 ALA A 124
LEU A  81
LEU A  88
ILE A  83
GLY A 143
None
1.12A 4dm8B-3hjrA:
undetectable
4dm8B-3hjrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 11 VAL A 381
LEU A 239
VAL A 393
LEU A 490
THR A 552
None
1.14A 4k0sA-3hjrA:
undetectable
4k0sA-3hjrA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
3 / 3 LEU A 438
PRO A 439
ARG A 465
None
0.73A 4klrB-3hjrA:
1.5
4klrB-3hjrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 ALA A 453
GLY A 456
SER A 385
ASN A 556
GLY A 583
None
1.18A 4obwA-3hjrA:
undetectable
4obwA-3hjrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 4 THR A 339
GLY A 179
ASP A 247
SER A 177
None
1.06A 4rfqA-3hjrA:
1.6
4rfqA-3hjrA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 SER A 244
THR A 342
THR A 339
ALA A 338
ALA A 215
None
1.46A 4u15A-3hjrA:
undetectable
4u15A-3hjrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 ASP A  87
THR A 296
THR A 295
TYR A 328
CA  A 601 (-2.1A)
None
None
None
1.42A 4w5qA-3hjrA:
2.4
4w5qA-3hjrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 ASP A  87
THR A 296
THR A 295
TYR A 328
CA  A 601 (-2.1A)
None
None
None
1.50A 4z4cA-3hjrA:
1.6
4z4cA-3hjrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 ASP A  87
THR A 296
THR A 295
TYR A 328
CA  A 601 (-2.1A)
None
None
None
1.47A 4z4fA-3hjrA:
undetectable
4z4fA-3hjrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 5 ASP A  87
THR A 296
THR A 295
TYR A 328
CA  A 601 (-2.1A)
None
None
None
1.47A 4z4gA-3hjrA:
2.2
4z4gA-3hjrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 6 ASP A  87
THR A 296
THR A 295
TYR A 328
CA  A 601 (-2.1A)
None
None
None
1.48A 4z4iA-3hjrA:
1.8
4z4iA-3hjrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 10 ALA A 352
LEU A 423
ALA A  62
LEU A 364
ALA A 422
None
1.10A 4zbrA-3hjrA:
undetectable
4zbrA-3hjrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.91A 5b1aC-3hjrA:
undetectable
5b1aJ-3hjrA:
undetectable
5b1aC-3hjrA:
17.67
5b1aJ-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.90A 5b1aP-3hjrA:
undetectable
5b1aW-3hjrA:
undetectable
5b1aP-3hjrA:
17.67
5b1aW-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.89A 5b3sC-3hjrA:
undetectable
5b3sJ-3hjrA:
undetectable
5b3sC-3hjrA:
17.67
5b3sJ-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.87A 5b3sP-3hjrA:
undetectable
5b3sP-3hjrA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 9 LEU A  68
GLY A  69
LEU A 348
LEU A  59
ALA A  62
None
1.12A 5dqfA-3hjrA:
undetectable
5dqfA-3hjrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 SER A 336
GLY A 219
GLY A 217
GLY A 334
ILE A 223
None
0.96A 5ekxA-3hjrA:
undetectable
5ekxA-3hjrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 ASN A 276
VAL A 257
ALA A 215
GLY A 179
None
0.89A 5fpdA-3hjrA:
undetectable
5fpdA-3hjrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 ASN A 276
VAL A 257
ALA A 215
GLY A 179
None
0.89A 5fpdB-3hjrA:
undetectable
5fpdB-3hjrA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 ALA A 345
TYR A 539
PHE A 253
PHE A 278
LEU A 432
None
1.18A 5fsaA-3hjrA:
undetectable
5fsaA-3hjrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
3 / 3 ARG A 232
ASN A 508
ASP A 184
None
0.88A 5gwxA-3hjrA:
undetectable
5gwxA-3hjrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 TYR A  37
VAL A  76
LEU A 141
GLY A 143
LEU A  38
None
0.95A 5ienA-3hjrA:
undetectable
5ienA-3hjrA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.89A 5iy5C-3hjrA:
undetectable
5iy5J-3hjrA:
undetectable
5iy5C-3hjrA:
17.41
5iy5J-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 SER A 268
ALA A 338
ILE A 417
LEU A  57
None
0.75A 5te8C-3hjrA:
undetectable
5te8C-3hjrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 7 SER A 271
ALA A 338
THR A 342
ILE A 213
LEU A 256
None
1.44A 5te8C-3hjrA:
undetectable
5te8C-3hjrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 THR A 339
LEU A 162
GLN A 202
GLU A 201
None
1.04A 5tudA-3hjrA:
undetectable
5tudA-3hjrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
3 / 3 ARG A 359
PRO A 433
TYR A 539
None
1.08A 5tzoB-3hjrA:
undetectable
5tzoB-3hjrA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 4 VAL A 266
LEU A 261
LEU A 416
ASP A  56
None
1.46A 5xv7A-3hjrA:
undetectable
5xv7A-3hjrA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.87A 5z84C-3hjrA:
undetectable
5z84J-3hjrA:
undetectable
5z84C-3hjrA:
17.67
5z84J-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.89A 5z85C-3hjrA:
undetectable
5z85J-3hjrA:
undetectable
5z85C-3hjrA:
17.67
5z85J-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.83A 5zcoC-3hjrA:
undetectable
5zcoJ-3hjrA:
undetectable
5zcoC-3hjrA:
17.67
5zcoJ-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.90A 5zcqC-3hjrA:
undetectable
5zcqJ-3hjrA:
undetectable
5zcqC-3hjrA:
17.67
5zcqJ-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 7 LEU A 196
GLN A 193
PHE A 200
LEU A 162
None
0.91A 5zcqP-3hjrA:
undetectable
5zcqW-3hjrA:
undetectable
5zcqP-3hjrA:
17.67
5zcqW-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 10 ALA A 125
ASP A  87
HIS A  85
VAL A 294
TYR A  37
CA  A 601 ( 4.9A)
CA  A 601 (-2.1A)
None
None
None
1.44A 6aogA-3hjrA:
undetectable
6aogA-3hjrA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 10 ALA A 125
ASP A  87
HIS A  85
VAL A 294
TYR A  37
CA  A 601 ( 4.9A)
CA  A 601 (-2.1A)
None
None
None
1.44A 6aogB-3hjrA:
undetectable
6aogB-3hjrA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 LEU A 316
GLY A 330
HIS A 317
GLN A  35
ILE A 122
None
1.34A 6bxnB-3hjrA:
2.4
6bxnB-3hjrA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 THR A 558
GLN A 560
THR A 573
SER A 514
VAL A 511
None
1.32A 6bzoC-3hjrA:
undetectable
6bzoC-3hjrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 12 SER A 343
ILE A 135
VAL A 173
THR A 282
LEU A 261
None
1.31A 6djzB-3hjrA:
undetectable
6djzB-3hjrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
5 / 11 ALA A  62
LEU A  59
ALA A 124
ALA A 347
LEU A  68
None
1.25A 6h1lB-3hjrA:
undetectable
6h1lB-3hjrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria)
4 / 8 GLY A 344
LEU A  68
GLY A  69
LEU A 348
None
0.73A 6mdqA-3hjrA:
undetectable
6mdqA-3hjrA:
8.54