SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hjw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		5 / 10 ALA A 320
VAL A 256
ILE A 292
GLY A 303
PRO A 254
 None
 1.13A 1d4sA-3hjwA:
undetectable		 1d4sA-3hjwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		5 / 10 HIS C  66
THR C  40
THR C  41
SER C  99
ALA C  98
 None
None
None
None
U  D  30 ( 3.5A)
 1.28A 1gtnO-3hjwC:
undetectable
1gtnP-3hjwC:
undetectable		 1gtnO-3hjwC:
24.79
1gtnP-3hjwC:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		5 / 9 HIS C  66
THR C  40
THR C  41
SER C  99
ALA C  98
 None
None
None
None
U  D  30 ( 3.5A)
 1.27A 1gtnQ-3hjwC:
undetectable
1gtnR-3hjwC:
undetectable		 1gtnQ-3hjwC:
24.79
1gtnR-3hjwC:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		5 / 12 PHE C  10
CYH C  71
LEU C  51
ILE C  53
ILE C  54
 None
 0.96A 1xdkF-3hjwC:
undetectable		 1xdkF-3hjwC:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		4 / 8 VAL A 196
GLY A 195
VAL A 131
ILE A 128
 None
 0.60A 2a1mB-3hjwA:
undetectable		 2a1mB-3hjwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		5 / 11 GLN A 104
ALA A 105
GLY A  79
THR A 100
ALA A  95
 U  D  44 ( 3.3A)
None
C  D  41 ( 3.3A)
G  D  42 ( 4.3A)
None
 1.19A 2f16V-3hjwA:
undetectable
2f16W-3hjwA:
undetectable		 2f16V-3hjwA:
22.42
2f16W-3hjwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		4 / 5 LEU A 289
MET A 293
LEU A 299
HIS A 252
 None
 1.27A 2qxsA-3hjwA:
undetectable		 2qxsA-3hjwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		5 / 9 ALA A 320
VAL A 256
ILE A 292
GLY A 303
PRO A 254
 None
 1.21A 3el4B-3hjwA:
undetectable		 3el4B-3hjwA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		4 / 8 TYR C  80
ALA C  98
THR C  37
LEU C  67
 None
U  D  30 ( 3.5A)
U  D  30 ( 3.6A)
None
 0.94A 3khmA-3hjwC:
undetectable		 3khmA-3hjwC:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		3 / 3 HIS A 118
HIS A 120
HIS A 199
 None
 0.64A 3mihA-3hjwA:
undetectable		 3mihA-3hjwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		5 / 12 LEU C  67
ILE C  63
GLY C  36
ALA C  97
VAL C  58
 None
U  D  30 ( 4.1A)
G  D  31 ( 3.3A)
A  D  29 ( 3.4A)
U  D  30 ( 3.6A)
 0.95A 4nkxB-3hjwC:
undetectable		 4nkxB-3hjwC:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		5 / 9 VAL C 112
ALA C  20
ARG C  28
ILE C  53
ILE C  79
 None
 1.02A 4oknB-3hjwC:
undetectable		 4oknB-3hjwC:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		4 / 8 ALA C  49
ILE C  76
LEU C  67
SER C  99
 None
 0.73A 4wboB-3hjwC:
undetectable		 4wboB-3hjwC:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		4 / 5 ALA A  99
ARG A  41
ALA A 249
GLU A 247
 None
 1.32A 5a06C-3hjwA:
undetectable
5a06D-3hjwA:
undetectable		 5a06C-3hjwA:
22.70
5a06D-3hjwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		3 / 3 ARG C  34
LYS C  35
GLU C  39
 G  D  24 ( 3.1A)
A  D  25 ( 2.7A)
G  D  31 ( 3.7A)
 0.76A 5d0yA-3hjwC:
undetectable		 5d0yA-3hjwC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		4 / 5 PRO C  60
LEU A  54
TYR A 226
PHE A 229
 None
 1.31A 5igjA-3hjwC:
undetectable		 5igjA-3hjwC:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		3 / 3 LEU A  84
TYR A 113
SER A 208
 None
 0.82A 5iktA-3hjwA:
undetectable		 5iktA-3hjwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		5 / 12 ILE A 187
GLU A 162
PHE A 135
ALA A 193
ILE A 166
 None
 1.34A 5iwuA-3hjwA:
undetectable		 5iwuA-3hjwA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3hjw PSEUDOURIDINE
SYNTHASE CBF5
(Pyrococcus
furiosus) 		5 / 12 VAL A  91
ASP A  55
GLU A 213
ARG A 174
ARG A 204
 None
 1.45A 5m50B-3hjwA:
undetectable		 5m50B-3hjwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		3 / 3 VAL C 112
LYS C 120
MET C 123
 None
 1.07A 5nknA-3hjwC:
undetectable		 5nknA-3hjwC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3hjw 50S RIBOSOMAL
PROTEIN L7AE
(Pyrococcus
furiosus) 		4 / 8 LEU C  51
ALA C  20
ILE C  26
ALA C  27
 None
 0.81A 5te8B-3hjwC:
undetectable		 5te8B-3hjwC:
13.59