SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 7 LEU A  38
SER A  37
LEU A  40
ALA A 309
 None
NA  A 340 ( 4.7A)
None
NA  A 340 (-3.4A)
 0.78A 1j8uA-3hjzA:
undetectable		 1j8uA-3hjzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 7 ASN A 172
PHE A 280
TYR A 215
ILE A 276
 None
 1.13A 1tdnA-3hjzA:
undetectable		 1tdnA-3hjzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 6 ALA A 146
GLU A 150
ILE A 134
LEU A 158
 None
 0.90A 1xvaA-3hjzA:
undetectable
1xvaB-3hjzA:
undetectable		 1xvaA-3hjzA:
20.34
1xvaB-3hjzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 12 ALA A 309
GLU A 312
LEU A 313
LEU A  40
GLY A  19
 NA  A 340 (-3.4A)
None
None
None
None
 0.98A 2jfaB-3hjzA:
undetectable		 2jfaB-3hjzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 7 ILE A 154
ILE A 143
LEU A 158
ILE A 175
 None
 0.87A 2q83A-3hjzA:
undetectable		 2q83A-3hjzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 11 LEU A 262
GLY A 260
LEU A   8
SER A   9
LEU A   5
 None
EDO  A 334 ( 4.7A)
None
EDO  A 338 (-3.5A)
EDO  A 338 (-4.0A)
 1.01A 2qmmA-3hjzA:
undetectable
2qmmB-3hjzA:
undetectable		 2qmmA-3hjzA:
22.22
2qmmB-3hjzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 8 ILE A  92
GLY A  94
ARG A  95
LEU A 244
 None
 0.82A 2vctB-3hjzA:
undetectable		 2vctB-3hjzA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 7 ILE A  92
GLY A  94
ARG A  95
LEU A 244
 None
 0.79A 2vctD-3hjzA:
undetectable		 2vctD-3hjzA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 9 LEU A 262
GLY A 260
LEU A   8
SER A   9
LEU A   5
 None
EDO  A 334 ( 4.7A)
None
EDO  A 338 (-3.5A)
EDO  A 338 (-4.0A)
 0.98A 3ai9X-3hjzA:
undetectable		 3ai9X-3hjzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 6 ASP A 101
LEU A 313
ASP A  78
LEU A 121
 NA  A 343 (-3.2A)
None
NA  A 341 (-3.8A)
None
 1.03A 3bj8C-3hjzA:
undetectable
3bj8D-3hjzA:
undetectable		 3bj8C-3hjzA:
21.79
3bj8D-3hjzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		3 / 3 ILE A 148
VAL A 112
ARG A 116
 None
 0.35A 3p73A-3hjzA:
undetectable		 3p73A-3hjzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 9 SER A  97
THR A  98
THR A  34
ASN A  35
ASP A  20
 None
None
None
EDO  A 336 (-3.9A)
SO4  A 349 (-3.7A)
 1.36A 3sfuA-3hjzA:
undetectable		 3sfuA-3hjzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		3 / 3 LYS A 117
SER A  59
GLN A  79
 None
 1.17A 3si7A-3hjzA:
undetectable		 3si7A-3hjzA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 11 THR A 139
SER A 307
GLU A  99
LEU A 299
PHE A 106
 CL  A 344 (-4.3A)
None
NA  A 340 ( 2.9A)
None
None
 1.29A 3tbgA-3hjzA:
undetectable		 3tbgA-3hjzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 12 LEU A 158
SER A 179
ILE A 119
ILE A 134
LEU A  89
 None
 1.32A 3w67D-3hjzA:
undetectable		 3w67D-3hjzA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 8 ASN A  35
ILE A  88
SER A  81
ALA A  42
 EDO  A 336 (-3.9A)
None
None
SO4  A 349 (-3.8A)
 1.00A 4eyzA-3hjzA:
undetectable		 4eyzA-3hjzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		4 / 8 ASN A  35
ILE A  88
SER A  81
ALA A  42
 EDO  A 336 (-3.9A)
None
None
SO4  A 349 (-3.8A)
 0.99A 4eyzB-3hjzA:
undetectable		 4eyzB-3hjzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 10 LEU A 244
PRO A 180
ALA A 167
GLU A 224
LEU A 239
 None
 1.41A 4la0A-3hjzA:
undetectable		 4la0A-3hjzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		3 / 3 THR A 223
ASN A 163
PHE A 162
 None
 0.64A 4pd9A-3hjzA:
undetectable		 4pd9A-3hjzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		3 / 3 MET A 226
ASP A  17
PHE A 251
 None
 0.98A 4xeyA-3hjzA:
undetectable		 4xeyA-3hjzA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		3 / 3 MET A 226
ASP A  17
PHE A 251
 None
 1.00A 4xeyB-3hjzA:
undetectable		 4xeyB-3hjzA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		3 / 3 LYS A 123
ILE A 119
ILE A 154
 None
 0.70A 4y0qA-3hjzA:
undetectable		 4y0qA-3hjzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 12 TYR A 278
GLU A 282
ALA A 146
PHE A 221
ALA A 173
 None
 1.15A 5n5dB-3hjzA:
undetectable		 5n5dB-3hjzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3hjz TRANSALDOLASE B
(Prochlorococcus
marinus) 		5 / 9 ILE A  88
ILE A  91
GLU A  99
VAL A  96
ILE A  92
 None
None
NA  A 340 ( 2.9A)
None
None
 1.23A 6hloA-3hjzA:
undetectable		 6hloA-3hjzA:
21.81