SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 8 LEU A  82
VAL A  96
GLY A  95
GLU A  54
 None
 1.00A 1jlfA-3hkaA:
undetectable
1jlfB-3hkaA:
undetectable		 1jlfA-3hkaA:
20.60
1jlfB-3hkaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_ACTB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 4 HIS A 368
PRO A 331
ASN A 330
TYR A 364
 None
 1.37A 2f7aB-3hkaA:
0.0		 2f7aB-3hkaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		3 / 3 ASN A 330
TYR A 364
SER A  90
 None
 0.91A 2gvcE-3hkaA:
undetectable		 2gvcE-3hkaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 6 LEU A   9
VAL A  13
LYS A  14
ILE A 396
 None
 0.63A 2piwA-3hkaA:
undetectable		 2piwA-3hkaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 5 VAL A 400
LEU A 403
ILE A 373
ALA A 374
 None
 0.94A 3n8yB-3hkaA:
undetectable		 3n8yB-3hkaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 5 LEU A  77
ALA A  65
MET A  56
THR A  59
 None
 1.11A 3vasB-3hkaA:
undetectable		 3vasB-3hkaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 7 TYR A  48
ARG A 170
HIS A  26
HIS A  49
 None
FIX  A 428 (-2.9A)
ZN  A 430 ( 3.3A)
FIX  A 428 ( 4.1A)
 1.48A 3zodA-3hkaA:
undetectable		 3zodA-3hkaA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 7 TYR A  50
ARG A 170
HIS A  26
HIS A  49
 FIX  A 428 ( 4.5A)
FIX  A 428 (-2.9A)
ZN  A 430 ( 3.3A)
FIX  A 428 ( 4.1A)
 1.27A 3zodA-3hkaA:
undetectable		 3zodA-3hkaA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 7 GLY A 237
TYR A 178
SER A 234
GLU A 179
 None
 0.82A 4hyfA-3hkaA:
undetectable		 4hyfA-3hkaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 8 GLY A 237
TYR A 178
SER A 234
GLU A 179
 None
 0.81A 4hyfB-3hkaA:
undetectable		 4hyfB-3hkaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 8 GLY A 237
TYR A 178
SER A 234
GLU A 179
 None
 0.85A 4hyfC-3hkaA:
undetectable		 4hyfC-3hkaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		5 / 9 LEU A 185
ASN A 235
VAL A 192
SER A 200
VAL A 204
 None
 1.18A 4qd3A-3hkaA:
undetectable		 4qd3A-3hkaA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		3 / 3 MET A  69
GLU A  73
LEU A  77
 None
 0.79A 4v2oB-3hkaA:
undetectable		 4v2oB-3hkaA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		3 / 3 ASP A 271
GLU A  44
SER A 223
 None
None
FIX  A 428 ( 4.1A)
 0.79A 5bw4B-3hkaA:
undetectable		 5bw4B-3hkaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 7 VAL A  22
ASN A 329
ILE A 334
LYS A 370
 None
 0.95A 5jh7C-3hkaA:
undetectable		 5jh7C-3hkaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 8 LEU A  51
LEU A  97
ILE A 334
GLN A 352
 None
 1.00A 5ljbA-3hkaA:
undetectable		 5ljbA-3hkaA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		3 / 3 HIS A  26
SER A 354
ARG A 357
 ZN  A 430 ( 3.3A)
None
FIX  A 428 (-3.9A)
 0.96A 5u63A-3hkaA:
undetectable		 5u63A-3hkaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		5 / 9 GLY A 273
VAL A 265
ASP A 271
GLY A 270
PRO A 267
 None
 1.35A 5zniA-3hkaA:
undetectable		 5zniA-3hkaA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		4 / 5 ASN A 330
TYR A 364
VAL A  96
LEU A  45
 None
 1.29A 6a7pA-3hkaA:
undetectable		 6a7pA-3hkaA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		5 / 10 PHE A 296
MET A 257
ALA A 256
THR A  27
PHE A 408
 None
 1.33A 6hu9C-3hkaA:
undetectable		 6hu9C-3hkaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3hka URONATE ISOMERASE
(Bacillus
halodurans) 		5 / 12 PHE A 296
MET A 257
ALA A 256
THR A  27
PHE A 408
 None
 1.34A 6hu9N-3hkaA:
undetectable		 6hu9N-3hkaA:
23.16