SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3hkl MUSCLE, SKELETAL
RECEPTOR TYROSINE
PROTEIN KINASE
(Rattus
norvegicus) 		5 / 11 PHE A 379
LEU A 378
ALA A 355
LEU A 373
TYR A 320
 None
 1.27A 1qabE-3hklA:
undetectable		 1qabE-3hklA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 3hkl MUSCLE, SKELETAL
RECEPTOR TYROSINE
PROTEIN KINASE
(Rattus
norvegicus) 		5 / 12 LEU A 437
GLU A 396
LEU A 450
HIS A 377
LEU A 373
 None
 1.19A 3erdA-3hklA:
undetectable		 3erdA-3hklA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3hkl MUSCLE, SKELETAL
RECEPTOR TYROSINE
PROTEIN KINASE
(Rattus
norvegicus) 		4 / 8 ILE A 393
ALA A 370
VAL A 431
PRO A 432
 None
 0.71A 4jltA-3hklA:
undetectable		 4jltA-3hklA:
17.34